2-methyl-2-(2-hydroxy-2-methylpropyl)-3-hydroxy-1,2-dihydroquinazolin-4-one | 225793-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-methyl-2-(2-hydroxy-2-methylpropyl)-3-hydroxy-1,2-dihydroquinazolin-4-one
• 英文别名: 3-hydroxy-2-methyl-2-(2-hydroxy-2-methylpropyl)-1,2-dihydroquinozalin-4-one；3-Hydroxy-2-methyl-2-(2-hydroxy-2-methylpropyl)-1,2-dihydroquinazolin-4-one；3-hydroxy-2-(2-hydroxy-2-methylpropyl)-2-methyl-1H-quinazolin-4-one
• CAS: 225793-27-1
• 化学式: C₁₃H₁₈N₂O₃
• 分子量: 250.298
• InChiKey: QTWWVUNSQLCGOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  72.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methyl-2-(2-hydroxy-2-methylpropyl)-3-hydroxy-1,2-dihydroquinazolin-4-one 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 9.0h， 生成 30benzyloxy-1,2-dihydroquinazolin-4-one
  参考文献：
  名称：

  Reactions of 3-hydroxy-1,2-dihydroquinazolin-4-ones with aldehydes

  摘要：

  The reactions of 3-hydroxy-2-(2-hydroxyalkyl)- [or (2-hydroxyaryl)]-1-1,2-dihydroquinazolin-4-ones with formaldehyde or acetaldehyde afford 1,3-oxazino[3,4-a]quinazolin-4-one derivatives. The reactions with other aldehydes RCHO and 3-hydroxy-2-R'-1,2-dihydroquinazolin-4-ones can give 3-hydroxy-2-R-1,2-dihydroquinazolin-4-ones, 2-substituted quinazolin-4-ones, or dianthranilide.

  DOI：

  10.1007/bf02641551
• 作为产物：
  描述：

  二丙酮醇 、 2-氨基-N-羟基苯甲酰胺 以 乙醇 为溶剂， 反应 4.0h， 以61%的产率得到2-methyl-2-(2-hydroxy-2-methylpropyl)-3-hydroxy-1,2-dihydroquinazolin-4-one
  参考文献：
  名称：

  Reactions of 3-hydroxy-1,2-dihydroquinazolin-4-ones with aldehydes

  摘要：

  The reactions of 3-hydroxy-2-(2-hydroxyalkyl)- [or (2-hydroxyaryl)]-1-1,2-dihydroquinazolin-4-ones with formaldehyde or acetaldehyde afford 1,3-oxazino[3,4-a]quinazolin-4-one derivatives. The reactions with other aldehydes RCHO and 3-hydroxy-2-R'-1,2-dihydroquinazolin-4-ones can give 3-hydroxy-2-R-1,2-dihydroquinazolin-4-ones, 2-substituted quinazolin-4-ones, or dianthranilide.

  DOI：

  10.1007/bf02641551

文献信息

• Reactions of 3-hydroxy-1,2-dihydroquinazolin-4-ones with acid chlorides
  作者：O. A. Luk'yanov、P. B. Gordeev

  DOI：10.1007/bf02495299

  日期：1999.7

  The reactions of 3-hydroxy-1,2-dihydroquinazolin-4-ones with acid chlorides can afford compounds of different types. The structures of the products depend on the type of acid chloride used and on the nature of the substituent at position 2 of the 3-hydroxy-1,2-dihydroquinazolin-4-one.

  3-羟基-1,2-二氢喹唑啉-4-酮与酰氯的反应可以得到不同类型的化合物。产物的结构取决于所用酰氯的类型和 3-羟基-1,2-二氢喹唑啉-4-one 的 2 位取代基的性质。
• Reactions of 3-hydroxy-1,2-dihydroquinazolin-4-ones with aldehydes
  作者：O. A. Luk'yanov、P. B. Gordeev

  DOI：10.1007/bf02641551

  日期：1998.12

  The reactions of 3-hydroxy-2-(2-hydroxyalkyl)- [or (2-hydroxyaryl)]-1-1,2-dihydroquinazolin-4-ones with formaldehyde or acetaldehyde afford 1,3-oxazino[3,4-a]quinazolin-4-one derivatives. The reactions with other aldehydes RCHO and 3-hydroxy-2-R'-1,2-dihydroquinazolin-4-ones can give 3-hydroxy-2-R-1,2-dihydroquinazolin-4-ones, 2-substituted quinazolin-4-ones, or dianthranilide.