1-((2-(dimethylamino)ethyl)(methyl)amino)propan-2-ol | 51253-72-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-((2-(dimethylamino)ethyl)(methyl)amino)propan-2-ol
• 英文别名: N,N,N'-Trimethyl-N'-β-hydroxypropyl-aethylendiamin；1-{[2-(Dimethylamino)ethyl](methyl)amino}propan-2-ol；1-[2-(dimethylamino)ethyl-methylamino]propan-2-ol
• CAS: 51253-72-6
• 化学式: C₈H₂₀N₂O
• 分子量: 160.26
• InChiKey: UMHOUSJWFUKPEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-((2-(dimethylamino)ethyl)(methyl)amino)propan-2-ol 在 sodium 作用下， 以 正己烷 为溶剂， 生成
  参考文献：
  名称：

  带有供体官能化的醇盐配体的铟络合物作为氧化铟薄膜的前体

  摘要：

  新颖铟配合物[（CH 3）2在（OR）] 2（1 - 7）使用一系列供体的合成-官能化的醇盐配体作为用于薄膜应用中具有潜在的前体。这些配合物显示出具有两个μ二聚体构2 -O金属中心之间的桥接。此外，这些络合物中的铟金属中心表现出五配位态，具有扭曲的三角-双锥体几何形状。通过傅立叶变换（FT）红外和FT核磁共振光谱，元素分析和热重分析（TGA）对复合物进行表征。配合物4和7的TGA曲线 在100–275°C时表现出单步质量损失，表明具有良好的挥发性和热稳定性。

  DOI：

  10.1016/j.jorganchem.2017.01.019

文献信息

• Amine catalyst for producing polyurethane foams and process for producing polyurethane foams
  申请人：Tosoh Corporation

  公开号：EP0469545A2

  公开（公告）日：1992-02-05

  An amine catalyst for producing polyurethane comprising a compound expressed by the following general formula (I): (in the formula, n is an integer from 0 to 3, and Ri, R2, and R3 respectively and independently stands for alkyl groups having 1 to 3 carbons). The amine catalyst has secondary hydroxyl group in the molecule It is of a non-bleeding type in the polyurethane resin and is excellent in moldability. Process for producing a polyurethane foam by reacting a polyol with a polyisocyanate in the presence of the above defined amine catalyst and a foaming agent.

  一种用于生产聚氨酯的胺催化剂，由以下通式(I)表示的化合物组成： (式中，n 为 0 至 3 的整数，Ri、R2 和 R3 分别独立地代表具有 1 至 3 个碳原子的烷基）。胺催化剂分子中含有仲羟基，在聚氨酯树脂中不会渗出，具有良好的成型性。在上述胺催化剂和发泡剂存在下，通过多元醇与多异氰酸酯反应生产聚氨酯泡沫塑料的工艺。
• AMINE CATALYST FOR CURING POLYISOCYANATE COMPOUND AND POLYISOCYANATE ADHESIVE COMPOSITION CONTAINING AMINE CATALYST FOR CURING POLYISOCYANATE COMPOUND
  申请人：Tosoh Corporation

  公开号：EP2878609A1

  公开（公告）日：2015-06-03

  To provide an amine catalyst for curing a polyisocyanate which can satisfy both initial moldability before a thermal compression step and high reactivity at the time of thermal compression molding, and an adhesive composition containing it. A catalyst comprising an amine compound (1) represented by the formula (1) and an amine compound (2) represented by the formula (2) is used as an amine catalyst for curing a polyisocyanate compound. wherein each of R1 and R2 which are independent of each other, is a C1-4 hydrocarbon group, and R3 is a C1-4 hydrocarbon group having a hydroxy group or an amino group; wherein each of R4 and R5 which are independent of each other, is a C1-4 hydrocarbon group, R6 is a C1-4 hydrocarbon group or a C1-4 hydrocarbon group having a hydroxy group or an amino group, R7 is a C1-4 hydrocarbon group having a hydroxy group or an amino group, and m is an integer of from 2 to 6.

  目的 提供一种用于固化多异氰酸酯的胺催化剂，该催化剂既能满足热压步骤前的初始模 塑性，又能满足热压成型时的高反应活性，并提供一种含有该催化剂的粘合剂组合物。 由式（1）表示的胺化合物（1）和式（2）表示的胺化合物（2）组成的催化剂用作固化多异氰酸酯化合物的胺催化剂。 其中相互独立的 R1 和 R2 均为 C1-4 烃基，R3 为具有羟基或氨基的 C1-4 烃基； 其中相互独立的R4和R5各自是C1-4烃基，R6是C1-4烃基或具有羟基或氨基的C1-4烃基，R7是具有羟基或氨基的C1-4烃基，m是2至6的整数。
• JPH00616760A
  申请人：——

  公开号：JPH00616760A

  公开（公告）日：1994-01-25
• JPH0616760A
  申请人：——

  公开号：JPH0616760A

  公开（公告）日：1994-01-25
• COMPOUNDS AND USES THEREOF
  申请人：LEAD DISCOVERY SIENA S.R.L.

  公开号：US20180186796A1

  公开（公告）日：2018-07-05

  The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine derivatives of formula I and IV able to target the Src family kinases (SFKs) such as Src, Fyn and Hck tyrosine kinases as well as Abl tyrosine kinase and uses and method of preparation thereof. In particular, the compounds of the invention are for use in the treatment and/or prevention of cancer, such as neuroblastoma (NB) or glioblastoma multiforme (GBM) or for use in the treatment and/or prevention of neurodegenerative diseases such as taupathies.