N,N',N''-trimethoxy-N,N',N''-trimethyl-triaminophosphine | 1062512-43-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N',N''-trimethoxy-N,N',N''-trimethyl-triaminophosphine
• 英文别名: N-bis[methoxy(methyl)amino]phosphanyl-N-methoxymethanamine
• CAS: 1062512-43-9
• 化学式: C₆H₁₈N₃O₃P
• 分子量: 211.201
• InChiKey: HXLURNQSMMRQDO-UHFFFAOYSA-N

物化性质

• 沸点：
  190.1±23.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N,N',N''-trimethoxy-N,N',N''-trimethyl-triaminophosphine 、 三甲基乙酸 以 甲苯 为溶剂， 以83%的产率得到N-甲氧基-N,2,2-三甲基丙酰胺
  参考文献：
  名称：

  A Powerful Reagent for Synthesis of Weinreb Amides Directly from Carboxylic Acids

  摘要：

  A powerful reagent, P[NCH3(OCH3)](3) (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH3(OCH3)13 was heated with aromatic and aliphatic carboxylic acids in toluene. The sterically hindered carboxylic acids can also give the corresponding Weinreb amides in excellent yields.

  DOI：

  10.1021/ol901886u
• 作为产物：
  描述：

  N-甲基-N-甲氧基胺盐酸盐 在 三乙胺 、 三氯化磷 作用下， 以 乙醚 为溶剂， 以67%的产率得到N,N',N''-trimethoxy-N,N',N''-trimethyl-triaminophosphine
  参考文献：
  名称：

  A Powerful Reagent for Synthesis of Weinreb Amides Directly from Carboxylic Acids

  摘要：

  A powerful reagent, P[NCH3(OCH3)](3) (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH3(OCH3)13 was heated with aromatic and aliphatic carboxylic acids in toluene. The sterically hindered carboxylic acids can also give the corresponding Weinreb amides in excellent yields.

  DOI：

  10.1021/ol901886u

文献信息

• Synthesis Studies on the Lomaiviticin A Aglycone Core: Development of a Divergent, Two-Directional Strategy
  作者：Ken S. Feldman、Brandon R. Selfridge

  DOI：10.1021/jo4005074

  日期：2013.5.3

  a two-directional, divergent approach featuring (1) a double Ireland Claisen rearrangement to establish key core bonds with correct relative stereochemistry and (2) a double olefin metathesis reaction to deliver both cyclohexene rings of the target.

  双环lomaiviticin糖苷配基A核的对映异构体是通过双向发散方法制备的，其特征为：（1）双重爱尔兰克莱森重排以建立具有正确相对立体化学的关键核键；（2）进行双烯烃复分解反应以同时传递环己烯目标的戒指。