4-bromo-2,3-bis(propylamino)-2H-furan-5-one | 1428867-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 4-bromo-2,3-bis(propylamino)-2H-furan-5-one
• CAS: 1428867-40-6
• 化学式: C₁₀H₁₇BrN₂O₂
• 分子量: 277.161
• InChiKey: AUEALUTUXQOPLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  正丙胺 、 5-acetoxy-3,4-dibromo-2(5H)-furanone 以 甲苯 为溶剂， 反应 1.5h， 以60%的产率得到4-bromo-2,3-bis(propylamino)-2H-furan-5-one
  参考文献：
  名称：

  Selective amination of the mucohalic acid derivatives

  摘要：

  An efficient synthesis of 4,5-diamino-3-halofuran-2(5H)-ones has been developed based on a sequential acylation and bisamination of mucohalic acids. The beta- and gamma-amination products have also been prepared with high regioselectivity. This reaction shows some advantages in terms of its simple operation and readily available but highly functionalized starting material. All products gave satisfactory IR, H-1 NMR, C-13 NMR and HRMS. (C) 2013 Xue-Qiang Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.01.035

文献信息

• Selective amination of the mucohalic acid derivatives
  作者：Tian-Cai Li、Cou-Xi Chen、Xue-Qiang Li、Xiao-Hui Gao

  DOI：10.1016/j.cclet.2013.01.035

  日期：2013.3

  An efficient synthesis of 4,5-diamino-3-halofuran-2(5H)-ones has been developed based on a sequential acylation and bisamination of mucohalic acids. The beta- and gamma-amination products have also been prepared with high regioselectivity. This reaction shows some advantages in terms of its simple operation and readily available but highly functionalized starting material. All products gave satisfactory IR, H-1 NMR, C-13 NMR and HRMS. (C) 2013 Xue-Qiang Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.