10-anilino-decan-1-ol | 155373-56-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 10-anilino-decan-1-ol
• 英文别名: 10-Anilinodecan-1-ol
• CAS: 155373-56-1
• 化学式: C₁₆H₂₇NO
• 分子量: 249.396
• InChiKey: NPFXOQVBJWZBLD-UHFFFAOYSA-N

物化性质

• 熔点：
  39 °C
• 沸点：
  389.5±15.0 °C(predicted)
• 密度：
  0.978±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  10-anilino-decan-1-ol 以 乙腈 为溶剂， 400.0~500.0 ℃ 、2.13 kPa 条件下， 反应 8.0h， 生成 (3E)-5-phenyl-1-oxa-5-azacyclopentadec-3-en-2-one
  参考文献：
  名称：

  合成大环化合物的新途径：大环烯胺内酯的合成

  摘要：

  大环enaminolactones 5在从commercialy可用chloroalcohols三个步骤制备1。环化步骤通过将羟基分子内亲核加成至由热解产生的氨基亚甲基乙烯酮来进行。

  DOI：

  10.1016/s0040-4039(00)76754-2
• 作为产物：
  描述：

  9-phenylcarbamoyl-nonanoic acid methyl ester 在 lithium aluminium tetrahydride 作用下， 生成 10-anilino-decan-1-ol
  参考文献：
  名称：

  The Synthesis of Some Amino Alcohols

  摘要：

  DOI：

  10.1021/ja01148a523

文献信息

• Thermochromic double-complex salts
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0277032A2

  公开（公告）日：1988-08-03

  Compositions of matter and methods of preparation are described for water and air stable, square planar transition metal double-complex salts which contain isonitrile ligands derivatized with long chain aliphatic groups. These salts are composed of two metal-containing complex ions: the cation is a tetrakis isonitrile metal ion and the anion is a tetrahalometallate or tetracyanometallate. These double-complex salts exhibit the novel property of thermochromism and are useful as temperature indicators and in imaging applications.

  描述了在水和空气中稳定的方形平面过渡金属双络合盐的物质组成和制备方法，这些盐含有用长链脂肪族基团衍生的异腈配位体。 这些盐由两个含金属的络合离子组成：阳离子是四异腈金属离子，阴离子是四卤金属酸盐或四氰金属酸盐。 这些双络合盐具有热致变色的新特性，可用作温度指示剂和成像应用。
• Ruthenium-Complex-Catalyzed N-(Cyclo)alkylation of Aromatic Amines with Diols. Selective Synthesis of <i>N</i>-(ω-Hydroxyalkyl)anilines of Type PhNH(CH₂)<i>_n</i>OH and of Some Bioactive Arylpiperazines
  作者：Rob A. T. M. Abbenhuis、Jaap Boersma、Gerard van Koten

  DOI：10.1021/jo972260d

  日期：1998.6.1

  A new class of well-defined neutral mono-, and dicationic ruthenium(II) complexes containing a neutral terdentate donor system [C5H3N(CH2E)(2)-2,6] (E = PPh2 (PNP) or NMe2 (NN'N)) has been found effective as catalyst precursor in N-(cyclo)alkylation reactions of aromatic amines with diols Y(CH2CH2OH)(2) (Y = CH2, NR). With these catalysts, N-phenylpiperidine is synthesized from aniline and 1,5-pentanediol in 85% yield (at 180 degrees C for 24 h in 1,4-dioxane). With neutral RuCl2(NN'N)(PPh3) as a catalyst precursor, aniline can be selectively N-monoalkylated with diols of the type HO(CH2)(n)OH (n = 4-6, 10) to give N-(n-hydroxyalkyl)anilines in 40-75% yield. To our knowledge, this represents the first useful catalytic route to this type of compounds. The new catalysts can also be used in the synthesis of arylpiperazines. For example, N-phenyl-N'-methylpiperazine is obtained from aniline and MeN(CH2CH2OH)(2) in yields up to 34%. N-[m-(Trifluoromethyl)phenyl]-N'-methylpiperazine, TFMPMP, is successfully produced from m-(trifluoromethyl)aniline and MeN(CH2CH2OH)(2) in 44% yield using monocationic [RuOTf(NN'N)(PPh3)]OTf as the catalyst precursor. A mechanism for the N-(cyclo)alkylation reaction is proposed.
• US4834909A
  申请人：——

  公开号：US4834909A

  公开（公告）日：1989-05-30
• US4971725A
  申请人：——

  公开号：US4971725A

  公开（公告）日：1990-11-20