3,9-diisopropyl-2,4,8,10-tetraoxaspiro<5.5>undecane | 69695-04-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 3,9-diisopropyl-2,4,8,10-tetraoxaspiro<5.5>undecane
• 英文别名: 3,9-Diisopropyl-2,4,8,10-tetraoxaspiro<5,5>undecan；3,9-diisopropyl-2,4,8,10-tetraoxaspiro-5,5-undecane；3,9-diisopropyl-2,4,8,10-tetraoxa-spiro[5.5]undecane；3,9-Diisopropyl-2,4,8,10-tetraoxa-spiro[5.5]undecan；4,9-Diisopropyl-3,5,8,10-tetraoxa-spiro-<5.5>-undecan, 'Pentaerythrit-diisobutyral'；2,4,8,10-Tetraoxaspiro[5.5]undecane, 3,9-bis(1-methylethyl)-；3,9-di(propan-2-yl)-2,4,8,10-tetraoxaspiro[5.5]undecane
• CAS: 69695-04-1
• 化学式: C₁₃H₂₄O₄
• 分子量: 244.331
• InChiKey: NEBWHJITDZAZPU-UHFFFAOYSA-N

物化性质

• 溶解度：
  7.69e-04 M

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,9-diisopropyl-2,4,8,10-tetraoxaspiro<5.5>undecane 在 溴 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以79%的产率得到3,9-Bis(1-bromo,1-methyl-ethyl)-2,4,8,10-tetraoxaspiro<5.5>undecane
  参考文献：
  名称：

  Zur Stereochemie einiger neuer chiraler Bromverbindungen mit einem 2,4,8,10-Tetraoxaspiro[5.5]-undecan ? Ger�st

  摘要：

  New compounds containing the 2,4,8,10-tetraoxaspiro[5.5] undecanic skeleton, substituted with brominated groups, have been synthesized by a regioselective radicalic bromination reaction. The stereochemistry of the compounds was studied by high resolution NMR methods. The anancomericity or the flipping of the rings was inferred from the conformational analysis. The chirality of the spiranic skeleton was investigated by means of the diastereotopicity of hydrogen and carbon atoms.

  DOI：

  10.1007/bf00811022
• 作为产物：
  描述：

  季戊四醇 、 异丁醛 在 硫酸 作用下， 以100%的产率得到3,9-diisopropyl-2,4,8,10-tetraoxaspiro<5.5>undecane
  参考文献：
  名称：

  一些基于多元醇缩醛及其衍生物的杂环化合物的生物活性

  摘要：

  体外研究了环状缩醛（五-和二季戊四醇、乙三醇和双甘油）和 5-乙基-5-羟甲基-1,3-二恶烷酯的生物活性。在 HEK293 和 SH-SY5Y 细胞系上建立了 5-乙基-5-羟甲基-1,3-二恶烷酯的细胞毒性特性。7,11,18,21-tetraoxaspiro-5,2,2,5-heneicosane, 2-[(5-ethyl-5-hydroxymethyl)-1,3-dioxan-2-yl]phenol, 4.4 的潜在抗氧化性能-[oxydi(methylene)]-bis-2-diisopropyl-1,3-dioxolane, 4,4_-[oxydi(methylene)]-bis-1,3-dioxolane, (5-ethyl-1,3-dioxan-使用氧化应激模型在体外建立了 5-yl)methyl-2-methyl 丙烯酸和双 (5-ethyl-1,3-dioxan-5-yl)methylmaleate。

  DOI：

  10.1007/s11094-020-02295-8

文献信息

• Compounds and methods for treating cancer
  申请人：YALE UNIVERSITY

  公开号：US10316037B1

  公开（公告）日：2019-06-11

  The present invention is directed to novel anticancer compounds which show excellent activity as anticancer agents. The present invention is also directed to pharmaceutical compositions based upon these compounds and methods of treating cancer, including drug resistant, multiple drug resistant, metastatic and recurrent cancer.

  本发明涉及新型抗癌化合物，表现出优异的抗癌活性。本发明还涉及基于这些化合物的药物组合物和治疗癌症的方法，包括对耐药性、多药耐药性、转移性和复发性癌症的治疗。
• OPTICAL FILM
  申请人：Motoyoshi Tetsuya

  公开号：US20100104777A1

  公开（公告）日：2010-04-29

  It is an object of the present invention to provide an optical film which has reverse chromatic dispersibility that its retardation becomes smaller as the wavelength becomes shorter and a low photoelastic constant. The optical film is made of a polycarbonate copolymer containing a unit (A) represented by the following formula: wherein R 1 and R 2 are each independently a hydrogen atom, hydrocarbon group having 1 to 10 carbon atoms or the like, R 3 and R 4 are each independently a hydrocarbon group having 1 to 10 carbon atoms or the like, “m” and “n” are each independently an integer of 0 to 4, and “p” and “q” are each independently an integer of 0 or more, and a unit (B) represented by the following formula: wherein R 5 to R 8 are each independently a hydrogen atom or alkyl group having 1 to 10 carbon atoms, the (A/B) molar ratio of the unit (A) to the unit (B) is 10/90 to 90/10 and which satisfies the following expression (1): R (450)< R (550)< R (650)  (1) wherein R(450), R(550) and R(650) are retardation values within the plane of the film at wavelengths of 450 nm, 550 nm and 650 nm, respectively.

  本发明的目的是提供一种光学薄膜，具有反色散性，其减速度随着波长的缩短而变小，且具有低光弹常数。该光学薄膜由聚碳酸酯共聚物制成，其中包含以下式表示的单元（A）：其中R1和R2分别是氢原子、具有1到10个碳原子的烃基或类似物，R3和R4分别是具有1到10个碳原子的烃基或类似物，“m”和“n”分别是0到4的整数，“p”和“q”分别是0或更多的整数，并且包含以下式表示的单元（B）：其中R5到R8分别是氢原子或具有1到10个碳原子的烷基，单元（A）与单元（B）的（A/B）摩尔比为10/90到90/10，并且满足以下式（1）：R(450)
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