(R,S)-di-sec-butylamine | 39056-20-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R,S)-di-sec-butylamine
• 英文别名: (r,s)-Di-s-butylamine；(2R)-N-[(2S)-butan-2-yl]butan-2-amine
• CAS: 39056-20-7
• 化学式: C₈H₁₉N
• 分子量: 129.246
• InChiKey: OBYVIBDTOCAXSN-OCAPTIKFSA-N

物化性质

• 熔点：
  122 °C
• 沸点：
  137.4±8.0 °C(Predicted)
• 密度：
  0.759±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R,S)-di-sec-butylamine 、 (S)-1-(2-Chloro-benzyl)-5-(R)-oxiranyl-pyrrolidin-2-one 以 正丁醇 为溶剂， 反应 140.0h， 以80%的产率得到(1S)-2<(1R,1'S)-bis(1-methylphenyl)amino-1-(5S)-1-<(2-chlorophenyl)methyl>-2-oxo-5-pyrrolidinyl>ethanol
  参考文献：
  名称：

  Three Stereoisomers of a Novel and Selective μ-Opioid Analgesic

  摘要：

  The crystal structures of the following three stereoisomers have been determined: (1S)-2-[(1R,1'R)-, (1S)-2-[(1S,1'S)- and (1S)-2-[(1R,1'S)-bis(l-methylpropyl)amino]-1-[(5S)-1- [(2-chlorophenyl)methyl]-2-oxo-5-pyrrolidinyl]ethanol, C21H33ClN2O2 The configurations at the stereocentres strongly influence both the hydrogen-bonding behaviour of the OH group and the packing. The conformations of the central N-C-C(OH)-C-N chains are particularly relevant to this behaviour and to the pharmacological activity.

  DOI：

  10.1107/s0108270195001478
• 作为产物：
  描述：

  (S)-2-butyl azide 、 (R)-2-butyldichloroborane-dimethylsulfide 在 水 作用下， 生成 (R,S)-di-sec-butylamine
  参考文献：
  名称：

  Chiral synthesis via organoboranes. 28. Reaction of .alpha.-chiral organyldichloroboranes with organyl azides providing a synthesis of secondary amines with exceptionally high enantiomeric purities

  摘要：

  2-Alkyl-1,3,2-dioxaborinanes R*BO2(CH2)3 of essentially 100% enantiomeric purity were prepared by the asymmetric hydroboration of readily available prochiral olefins with mono- or diisopinocampheylboranes, followed by removal of the chiral auxiliary (alpha-pinene). The intermediate R*BO2(CH2)3 reacts readily with lithium aluminum hydride at 0-degrees-C to give the corresponding lithium monoalkylborohydrides stereospecifically in very good yields and in very high enantiomeric purities. The lithium monoalkylborohydrides, on treatment with hydrogen chloride in dimethyl sulfide, give the corresponding monoalkyldichloroboranes in very high enantiomeric purity. The intermediate monoalkyldichloroboranes react readily with organic azides in 1,2-dichloroethane with evolution of gaseous nitrogen and transfer of the organic group from boron to nitrogen with complete retention of configuration to provide the corresponding secondary amines, either (+)- or (-), in very high yields and exceptionally high enantiomeric purities. The procedure was applied to the synthesis of representative optically active amines of high enantiomeric purities (ee or de greater-than-or-equal-to 99%), including (2S,2'S)-di-2-butylamine, N-[(2S)-2-methyl-1-butyl]-(1S,2R)-trans-2-phenycyclopentylamine, N-[(3S)-3,7-dimethyloct-6-enyl](1S,2S)-trans-2-methylcyclohexylamine, and the meso-di-2-butylamine.

  DOI：

  10.1021/jo00003a046

文献信息

• Heat transfer liquid composition and energy saving heating method using it
  申请人：Stephano CHM gcv

  公开号：EP2799511A2

  公开（公告）日：2014-11-05

  This invention provides a heat transfer liquid medium comprising a mixture of water and a reaction product of an alkanolamine wherein the alkyl group has from 2 to 4 carbon atoms and an inorganic acid having a pKa from 1 to 14, wherein the weight proportion of water in said mixture is from 10% to 95%, and wherein the weight proportion of the reaction product in said mixture is from 5% to 90%. When used in a circulating system for heating a room, this heat transfer liquid medium provides significant energy and cost savings.

  本发明提供了一种传热液体介质，包括水和烷醇胺反应产物的混合物，其中烷基具有 2 至 4 个碳原子，无机酸的 pKa 为 1 至 14，水在混合物中的重量比例为 10% 至 95%，反应产物在混合物中的重量比例为 5% 至 90%。 在用于加热房间的循环系统中使用时，这种导热液体介质可显著节约能源和成本。
• ALDIMINES ET LEURS UTILISATIONS
  申请人：BOSTIK SA

  公开号：EP3838891A1

  公开（公告）日：2021-06-23

  La présente invention concerne des composé ayant l'une des formules (I) ou (II) suivantes : ainsi que leurs utilisations.

  本发明涉及具有下式（I）或（II）之一的化合物： 的化合物及其用途。
• Compounds with central analgesic activity, process for their preparation and pharmaceutical compositions containing them
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0342613B1

  公开（公告）日：1992-11-11
• BROWN, HERBERT C.;SALUNKHE, ASHOK M.;SINGARAM, BAKTHAN, J. ORG. CHEM., 56,(1991) N, C. 1170-1175
  作者：BROWN, HERBERT C.、SALUNKHE, ASHOK M.、SINGARAM, BAKTHAN

  DOI：——

  日期：——
• MORPHOLINOPURINE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2336132B1

  公开（公告）日：2014-01-01