5-methanesulfonyl-pentanenitrile | 54863-38-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 5-methanesulfonyl-pentanenitrile
• 英文别名: 5-Methylsulfon-valeronitril；Pentanenitrile, 5-(methylsulfonyl)-；5-methylsulfonylpentanenitrile
• CAS: 54863-38-6
• 化学式: C₆H₁₁NO₂S
• 分子量: 161.225
• InChiKey: AUVQOHFFHTVMSV-UHFFFAOYSA-N

物化性质

• 沸点：
  386.1±25.0 °C(Predicted)
• 密度：
  1.135±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-methanesulfonyl-pentanenitrile 、 氯化苄 生成 2-Benzyl-5-methylsulfon-valeronitril
  参考文献：
  名称：

  Truce,W.E. et al., Journal of Organic Chemistry, 1962, vol. 27, p. 2821 - 2828

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氯戊腈 在 双氧水 作用下， 以 乙醇 、 乙酸酐 、 溶剂黄146 为溶剂， 生成 5-methanesulfonyl-pentanenitrile
  参考文献：
  名称：

  Truce,W.E. et al., Journal of Organic Chemistry, 1962, vol. 27, p. 2821 - 2828

  摘要：

  DOI：

文献信息

• PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATION AND PAIN
  申请人：OLATEC INDUSTRIES LLC

  公开号：US20130324603A1

  公开（公告）日：2013-12-05

  The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a methanesulfonylalkylnitrile compound, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering a methanesulfonylalkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

  本发明涉及一种制药组合物，包括一种药用可接受载体和一种甲烷磺酰基烷基硝基化合物，或其药用可接受盐或溶剂。本发明还涉及一种治疗炎症、炎症相关疾病或疼痛的方法，通过向需要治疗的受体中给予甲烷磺酰基烷基硝基化合物或其药用可接受盐或溶剂。
• MACROCYCLIC INTEGRASE INHIBITORS
  申请人：Thuring Johannes Wilhelmus J.

  公开号：US20130035341A1

  公开（公告）日：2013-02-07

  Compound having formula I and pharmaceutically acceptable salts or solvates thereof, their pharmaceutical formulations and use as HIV inhibitors.

  化学式为I的化合物及其药学上可接受的盐或溶剂化物，它们的制药配方和用途是HIV抑制剂。
• Pharmaceutical composition for treating inflammation and pain
  申请人：Olatec Therapeutics LLC

  公开号：US10751316B2

  公开（公告）日：2020-08-25

  The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a methanesulfonylalkylnitrile compound, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering a methanesulfonylalkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

  本发明涉及一种药物组合物，该组合物包含药学上可接受的载体和甲磺酰基烷基腈化合物或其药学上可接受的盐或溶液。本发明还涉及一种治疗炎症、炎症相关疾病或疼痛的方法，其方法是向有需要的受试者施用甲磺酰基烷基腈化合物或其药学上可接受的盐或溶液。
• US8716293B2
  申请人：——

  公开号：US8716293B2

  公开（公告）日：2014-05-06
• [EN] PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATION AND PAIN<br/>[FR] COMPOSITION PHARMACEUTIQUE POUR TRAITER L'INFLAMMATION ET LA DOULEUR
  申请人：OLATEC IND LLC

  公开号：WO2013184703A1

  公开（公告）日：2013-12-12

  The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a methanesulfonylalkylnitrile compound, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering a methanesulfonylalkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.