6-pyridin-3-yl-5,6-dihydro-benzo[4,5]imidazo[1,2-c]-quinazoline | 326618-68-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-pyridin-3-yl-5,6-dihydro-benzo[4,5]imidazo[1,2-c]-quinazoline
• 英文别名: 6-Pyridin-3-yl-6,12-dihydrobenzimidazolo[1,2-c]quinazoline；6-pyridin-3-yl-5,6-dihydrobenzimidazolo[1,2-c]quinazoline
• CAS: 326618-68-2
• 化学式: C₁₉H₁₄N₄
• 分子量: 298.347
• InChiKey: WANGEGRFNQGOGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  42.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻苯二胺 以 甲醇 、 乙醇 为溶剂， 反应 11.5h， 生成 6-pyridin-3-yl-5,6-dihydro-benzo[4,5]imidazo[1,2-c]-quinazoline
  参考文献：
  名称：

  Design and synthesis of fluorescent 6-aryl[1,2-c]quinazolines serving as selective and sensitive ‘on-off’ chemosensor for Hg2+ in aqueous media

  摘要：

  Three fluorescent quinazolines thiophen-2-yl-5,6-dihydrobenzo-[4,5]imidazo[1,2-c]quinazoline (1), Pyridin-3-yl-5,6-dihydrobenzo-[4,5]imidazo-[1,2-c]quinazoline (2) and phenyl-5,5',6,6'-dihydrobenzo-[4,4',5,5']imidazo-[1.1',2-c,2'-c]quinazoline (3) have been synthesized. Structures of 1 and 3 have been authenticated crystallographically. Quinazolines 1-3 exhibit highly selective 'on-off' switching for Hg2+ ions. The fluorescence intensity displayed a linear relationship with respect to Hg2+ concentration (0.1-1.0 mu M; R-2 = 0.99) with detection limit of 2.0 x 10(-7) M. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.128

文献信息

• Design and synthesis of fluorescent 6-aryl[1,2-c]quinazolines serving as selective and sensitive ‘on-off’ chemosensor for Hg2+ in aqueous media
  作者：Rampal Pandey、Mahendra Yadav、Mohammad Shahid、Arvind Misra、Daya Shankar Pandey

  DOI：10.1016/j.tetlet.2012.04.128

  日期：2012.7

  Three fluorescent quinazolines thiophen-2-yl-5,6-dihydrobenzo-[4,5]imidazo[1,2-c]quinazoline (1), Pyridin-3-yl-5,6-dihydrobenzo-[4,5]imidazo-[1,2-c]quinazoline (2) and phenyl-5,5',6,6'-dihydrobenzo-[4,4',5,5']imidazo-[1.1',2-c,2'-c]quinazoline (3) have been synthesized. Structures of 1 and 3 have been authenticated crystallographically. Quinazolines 1-3 exhibit highly selective 'on-off' switching for Hg2+ ions. The fluorescence intensity displayed a linear relationship with respect to Hg2+ concentration (0.1-1.0 mu M; R-2 = 0.99) with detection limit of 2.0 x 10(-7) M. (C) 2012 Elsevier Ltd. All rights reserved.