1,6-di-O-(triphenylmethyl)-D-mannitol | 29780-94-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1,6-di-O-(triphenylmethyl)-D-mannitol
• 英文别名: 1,6-di-O-trityl-D-mannitol；1.6-di-O-trityl-D-mannitol；1.6-Bis-triphenylmethoxy-D-manno-hexantetrol-(2.3.4.5)；1.6-Bis-O-triphenylmethyl-D-mannit；1.6-Di-O-trityl-D-mannit；(2R,3R,4R,5R)-1,6-ditrityloxyhexane-2,3,4,5-tetrol
• CAS: 29780-94-7
• 化学式: C₄₄H₄₂O₆
• 分子量: 666.814
• InChiKey: LKNNCZGQSCNZAY-BMGLKWEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  50
• 可旋转键数：
  15
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,6-di-O-(triphenylmethyl)-D-mannitol 在 草酰氯 、 硫酸 、 sodium hydride 、 二甲基亚砜 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.42h， 生成 2,3,4,5-tetra-O-benzyl-D-manno-hexodialdose
  参考文献：
  名称：

  Synthesis of cyclitols fused with a furoxan ring from alditols by intramolecular nitrile oxide dimerization

  摘要：

  通过将一种醛糖醇转化为双（醛肟），并进一步用N-氯丁二酰亚胺氧化肟基团至腈氧化物，这些腈氧化物自发地进行分子内二聚合形成呋罗环，实现了与呋罗环融合的环醇的合成。

  DOI：

  10.1039/a704208f
• 作为产物：
  描述：

  甘露醇 生成 1,6-di-O-(triphenylmethyl)-D-mannitol
  参考文献：
  名称：

  Mueller, Chemische Berichte, 1932, vol. 65, p. 1055,1058

  摘要：

  DOI：

文献信息

• A straightforward synthesis of perbenzylated conduritols from alditols by ring closing olefin metathesis
  作者：John K. Gallos、Theocharis V. Koftis、Vassiliki C. Sarli、Konstantinos E. Litinas

  DOI：10.1039/a906626h

  日期：——

  The synthesis of perbenzylated conduritols A, E and F has been achieved in six steps by formal conversion of galactitol, D-mannitol and D-glucitol into the respective terminal dienes, followed by ring closing olefin metathesis.

  通过将半乳糖醇、D-甘露醇和D-葡萄糖醇正式转化为相应的末端二烯，随后进行环闭合烯烃复分解反应，实现了苯甲酰化康杜利托醇A、E和F的六步合成。
• Stereoregular poly-<i>O</i>-methyl [<i>m,n</i>]-polyurethanes derived from<scp>D</scp>-mannitol
  作者：Daniela M. Fidalgo、Adriana A. Kolender、Oscar Varela

  DOI：10.1002/pola.26406

  日期：2013.1.15

  Novel linear carbohydrate‐derived [m,n]‐polyurethanes are successfully prepared using D‐mannitol as renewable and low cost starting material. The key comonomer, 1,6‐di‐O‐phenylcarbonyl‐2,3,4,5‐tetra‐O‐methyl‐D‐mannitol is polymerized with a diamine synthesized from D‐mannitol or with alkylenediamines. These polymerization reactions afford, respectively, a [6,6]‐polyurethane entirely based on a carbohydrate

  使用D-甘露醇作为可再生的低成本起始原料成功制备了新型线性碳水化合物衍生的[ m，n ]-聚氨酯。关键的共聚单体1,6-二-O-苯基羰基-2,3,4,5-四-O-甲基-D-甘露醇与D-甘露醇合成的二胺或亚烷基二胺聚合而成。这些聚合反应分别提供了一种完全基于碳水化合物衍生物的[ 6,6 ]-聚氨酯，或由一个由聚-O-甲基取代的单元与一个聚亚甲基链交替组成的[ m，n ]-聚氨酯。由于C的存在，所有这些聚合物都是立体有规的2甘露糖醇的对称轴。光学活性聚氨酯通过标准方法（FTIR，RMN，GPC，TGA和DSC）进行表征。因此，GPC分析显示重均分子量在18,000和25,000 Da之间。热学研究（DSC）表明，所获得的聚合物是无定形材料，其T g值取决于二胺成分的结构和链长。©2012 Wiley Periodicals，Inc. J Polym Sci A部分：Polym Chem，2013年
• NOVEL CROSSLINKING REAGENTS, MACROMOLECULES, THERAPEUTIC BIOCONJUGATES, AND SYNTHETIC METHODS THEREOF
  申请人：CellMosaic, Inc.

  公开号：US20150017246A1

  公开（公告）日：2015-01-15

  The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention.

  本发明提供了基于糖醇的新型化学物质。这些新型化学物质具有生物相容性和生物可降解性，分子可以制备成单一和纯净的形式。这些分子的分子量范围从小（<1000 Da）到大（1000-120000 Da）。基于糖醇的分子可以在整个分子中具有功能性基团，用于交联化合物，例如制备抗体药物偶联物，或促进治疗性蛋白质、肽、siRNA和化学治疗药物的传递。本发明还提供了通过糖醇分子制备的新型偶联实体。本发明还涉及合成基于糖醇的分子和偶联物的方法。
• NOVELCROSSLINKING REAGENTS, MACROMOLECULES, THERAPEUTIC CONJUGATES, AND SYNTHETIC METHODS THEREOF
  申请人：CellMosaic, Inc.

  公开号：US20140206903A1

  公开（公告）日：2014-07-24

  The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention.

  本发明提供了基于糖醇的新型化合物。这些新型化合物具有生物相容性和生物可降解性。这些分子可以以单一纯形式制备。这些分子的分子量范围从小分子（<1000 Da）到大分子（1000-120,000 Da）。基于糖醇的分子可以在整个分子中具有功能性基团，用于交联化合物，例如制备抗体药物偶联物，或促进治疗性蛋白质、肽、siRNA和化学治疗药物的传递。还提供了通过糖醇分子制备的新型偶联实体。本发明还涉及制备基于糖醇的分子和偶联物的方法。
• Crosslinking reagents, macromolecules, therapeutic conjugates, and synthetic methods thereof
  申请人：CellMosaic, Inc.

  公开号：US08907079B2

  公开（公告）日：2014-12-09

  The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention.

  本发明提供了基于糖醇的新型化学实体。这些新型化学实体具有生物相容性和生物降解性。这些分子可以制备成单一和纯净的形式。这些分子的分子量范围从小（<1000 Da）到大（1000-120,000 Da）。基于糖醇的分子可以在分子内具有功能性基团，用于交联化合物，例如制备抗体药物偶联物，或促进治疗性蛋白质、肽、siRNA和化疗药物的递送。还提供了通过糖醇分子制备的新型偶联实体。本发明还涉及合成基于糖醇的分子和偶联物的方法。