5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[5-[(4-aminophenyl)methylamino]-5-oxopentyl]pentanamide | 443770-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[5-[(4-aminophenyl)methylamino]-5-oxopentyl]pentanamide
• CAS: 443770-00-1
• 化学式: C₂₂H₃₃N₅O₃S
• 分子量: 447.602
• InChiKey: PZKZEYLZJDOSKC-WFXMLNOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  151
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-硝基苄胺 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 28.0h， 生成 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[5-[(4-aminophenyl)methylamino]-5-oxopentyl]pentanamide
  参考文献：
  名称：

  Design and Synthesis of Biotin Chain-Terminated Glycopolymers for Surface Glycoengineering

  摘要：

  Biotin chain-terminated glycopolymers were generated by cyanoxyl-mediated free-radical polymerization using a biotin-derivatized arylamine initiator with high conversion (75%) and low polydispersity (1.30). Streptavidin-biotinylated glycopolymer binding was verified by SDS-PAGE gel shift assay and patterned glycocalyx-mimetic surfaces successfully fabricated.

  DOI：

  10.1021/ja025788v

文献信息

• Design and Synthesis of Biotin Chain-Terminated Glycopolymers for Surface Glycoengineering
  作者：Xue-Long Sun、Keith M. Faucher、Michelle Houston、Daniel Grande、Elliot L. Chaikof

  DOI：10.1021/ja025788v

  日期：2002.6.1

  Biotin chain-terminated glycopolymers were generated by cyanoxyl-mediated free-radical polymerization using a biotin-derivatized arylamine initiator with high conversion (75%) and low polydispersity (1.30). Streptavidin-biotinylated glycopolymer binding was verified by SDS-PAGE gel shift assay and patterned glycocalyx-mimetic surfaces successfully fabricated.