申请人:Queen's University at Kingston
公开号:US20040208875A1
公开(公告)日:2004-10-21
Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier molecules include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.
描述了用于抑制主体中淀粉样沉积的治疗化合物和方法,无论其临床环境如何。通过向主体投入包含阴离子基团和载体分子的治疗化合物的有效量或其药用可接受盐,从而抑制淀粉样沉积。这样,淀粉样沉积受到抑制,使淀粉样蛋白与基底膜成分之间的相互作用受到抑制。优选的阴离子基团包括磺酸盐和硫酸盐。优选的载体分子包括碳水化合物、聚合物、肽、肽衍生物、脂肪基团、脂环基团、杂环基团、芳香基团及其组合。