3-(4-methoxybenzoyloxy)benzaldehyde | 146952-27-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 3-(4-methoxybenzoyloxy)benzaldehyde
• 英文别名: 3-formylphenyl 4-methoxybenzoate；4-methoxy-benzoic acid-(3-formyl-phenyl ester)；4-Methoxy-benzoesaeure-(3-formyl-phenylester)；(3-formylphenyl) 4-methoxybenzoate
• CAS: 146952-27-4
• 化学式: C₁₅H₁₂O₄
• mdl: MFCD03217385
• 分子量: 256.258
• InChiKey: AZDDZTAYYQDDSA-UHFFFAOYSA-N

物化性质

• 沸点：
  426.6±30.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-methoxybenzoyloxy)benzaldehyde 在 甲醇 、 potassium permanganate 作用下， 生成 3-(4-methoxy-benzoyloxy)-benzoic acid
  参考文献：
  名称：

  321.一种合成糊精的新方法

  摘要：

  DOI：

  10.1039/jr9320002263
• 作为产物：
  描述：

  4-甲氧基苯甲醛 在 4-二甲氨基吡啶 、 potassium permanganate 、 sodium dihydrogenphosphate 、 ammonium cerium (IV) nitrate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.25h， 生成 3-(4-methoxybenzoyloxy)benzaldehyde
  参考文献：
  名称：

  2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

  摘要：

  The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 mu g/ml; MIC(LORA) 2.06 and 1.59 mu g/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 mu M respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 mu M respectively) followed by the Vit-K2 rescue study and ATP production assay.

  DOI：

  10.1016/j.bioorg.2020.104170

文献信息

• Liquid crystal polymers copolymers and elastomers containing a laterally attached mesogenic unit
  作者：Eric A. Whale、Frederick J. Davis、Geoffrey R. Mitchell

  DOI：10.1039/jm9960601479

  日期：——

  The synthesis of a closely-coupled laterally attached side-chain liquid crystal polymer is described. The material exhibits liquid crystalline behaviour over a wide temperature range. Incorporation of non-mesogenic methyl acrylate as a comonomer with the potentially mesogenic monomer results in copolymers which are liquid crystalline, even when the non-mesogenic portion exceeds 60 mol%. Macroscopic alignment can be readily realised in both homopolymer and copolymer samples, either using a magnetic field or by pulling as fibres, and X-ray scattering shows the level of global orientation to be relatively high. Copolymerisation of the mesogenic unit with ca. 10 mol% of hydroxyethyl acrylate results in materials which can be cross-linked by reaction with a diisocyanate. The application of mechanical stress to liquid crystalline elastomers based on this closely coupled unit results in some global orientation of the mesogens, and the stress-strain-orientation behaviour of this cross-linked system is described. Both copolymers and elastomers are compared with liquid crystal polymers in which the mesogen is attached via a terminal linkage.

  本文描述了一种紧密耦合侧链液晶聚合物的合成过程。这种材料在很宽的温度范围内都表现出液晶特性。将非介源型丙烯酸甲酯作为共聚单体与潜在的介源型单体结合在一起，可产生液晶共聚物，即使非介源型部分超过 60 摩尔%。在均聚物和共聚物样品中，通过磁场或纤维拉动，很容易实现宏观配向，X 射线散射显示全局配向水平相对较高。介源单元与约 10 摩尔%的丙烯酸羟乙酯共聚后，可生成与二异氰酸酯反应交联的材料。对以这种紧密耦合单元为基础的液晶弹性体施加机械应力会导致中间体的某些全局取向，并描述了这种交联系统的应力-应变-取向行为。共聚物和弹性体都与液晶聚合物进行了比较，在液晶聚合物中，介质是通过终端链接连接的。
• 2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms
  作者：Anand Babu Velappan、Dhrubajyoti Datta、Rui Ma、Shiwani Rana、Kalyan Sundar Ghosh、Natarajan Hari、Scott G. Franzblau、Joy Debnath

  DOI：10.1016/j.bioorg.2020.104170

  日期：2020.10

  The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 mu g/ml; MIC(LORA) 2.06 and 1.59 mu g/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 mu M respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 mu M respectively) followed by the Vit-K2 rescue study and ATP production assay.
• 321. A new method for the synthesis of depsides
  作者：T. Currie、Alfred Russell

  DOI：10.1039/jr9320002263

  日期：——