5-Aethyl-1,3-dioxan | 1121-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 5-Aethyl-1,3-dioxan
• 英文别名: 5-Ethyl-1,3-dioxane
• CAS: 1121-56-8
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: NEGZOIAWCFYOBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] HEPATITIS C INHIBITOR COMPOUNDS<br/>[FR] COMPOSES INHIBITEURS DE L'HEPATITE C
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2004103996A1

  公开（公告）日：2004-12-02

  Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.

  公式（I）的化合物：其中B、X、R3、L0、L1、L2、R2、R1和RC的定义如本文所述。这些化合物可用作丙型肝炎病毒NS3蛋白酶的抑制剂，用于治疗丙型肝炎病毒感染。
• [EN] BROAD SPECTRUM ANTIVIRALS AGAINST CORONAVIRUS<br/>[FR] ANTIVIRAUX À LARGE SPECTRE CONTRE LE CORONAVIRUS
  申请人：UNIV KANSAS STATE

  公开号：WO2021202460A1

  公开（公告）日：2021-10-07

  Compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: (I) where X comprises a cyclic moiety, R2 is a branched or unbranched alkyl, cycloalkyl, aryl, arylalkyl, alkenyl, alkynyl, amino acid side chain, bicyclic or tricyclic side chain, combinations, and substituted forms thereof, and Z is selected from the group consisting of C1-C6 hydroxyalkyl, aldehydes, alpha- ketoamides, and bisulfite salts, and in particular -CH2OH, -CHO, -CH(0H)S03 -Na+, and - [0(C=0)Rw]S03 -Na+.

  显示抗病毒活性和/或针对病毒复制的抑制作用的化合物，特别是属于类似小核糖病毒超簇的病毒，包括具有以下结构的冠状病毒：（I），其中X包括一个环状基团，R2是支链或非支链烷基，环烷基，芳基，芳基烷基，烯基，炔基，氨基酸侧链，双环或三环侧链，它们的组合和取代形式，Z选自羟基烷基，醛，α-酮胺和亚硫酸盐等物种组成的群体，特别是-CH2OH，-CHO，-CH(0H)S03-Na+，以及-[0(C=0)Rw]S03-Na+。
• Substituted benzoylpyrazoles as herbicides
  申请人：van Almsick Andreas

  公开号：US20050282709A1

  公开（公告）日：2005-12-22

  A description is given of benzoylpyrazoles of the formula (I) and of their use as herbicides. In this formula (I) R 1 , R 2 , R 6 , R 7 and R 8 are different radicals and Het is a saturated heterocyclic group including oxygen atoms and carbon atoms.

  给出了化学式（I）的苯甲酰吡唑的描述，以及它们作为除草剂的用途。在这个化学式（I）中，R1、R2、R6、R7和R8是不同的基团，Het是一个饱和的杂环基团，包括氧原子和碳原子。
• Substituted benzoylcyclohexanediones as herbicides
  申请人：Van Almsick Andreas

  公开号：US20050282710A1

  公开（公告）日：2005-12-22

  A description is given of derivatives of benzoylcyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I) R 1 and R 2 are different radicals and Het is a saturated heterocyclic group comprising oxygen atoms and carbon atoms.

  本文介绍了苯甲酰环己烷二酮衍生物的公式(I)以及它们作为除草剂的用途。在公式(I)中，R1和R2是不同的基团，Het是一个饱和的杂环基团，包括氧原子和碳原子。
• SUBSTITUTED CYCLOALKENE DERIVATIVE
  申请人：Kimura Tomio

  公开号：US20090233952A1

  公开（公告）日：2009-09-17

  [Object] To provide a substituted cycloalkene derivative having an action to suppress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a medicament containing them as an active ingredient, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation. [Solution] A compound represented by the general formula (I): wherein X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A (the ring is 3- to 7-membered heterocyclyl ring or 3- to 7-membered cycloalkyl ring), each represents a hydrogen atom, or X and Y together represent a substituent of ring B. l and m, independently from each other, represent an integer of 0 to 3, and l+m is 1 to 3. R 1 is an aliphatic hydrocarbon group and the like which may be substituted with a group selected from Substituent group β and Substituent group γ. n represents an integer of 0 to 3. R 2 is a C 1 -C 6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. R 3 is a phenyl group, 5- to 6-membered heteroaryl group and the like which may be substituted with a group selected from Substituent group ε. R 5 is a C 1 -C 6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. Provided that in the case where R 3 is a phenyl group which may be substituted with a group selected from Substituent group ε, X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A, or X and Y together represent a substituent of ring B.

  [目的] 提供一种替代环烯烃衍生物，具有抑制内毒素诱导的细胞内信号传导或细胞活化并抑制细胞对细胞内信号传导和细胞活化的反应，例如过量生成TNF-α等炎症介质，其药理学上可接受的盐，包含其作为活性成分的药物，其制备方法以及含有上述替代环烯烃衍生物作为活性成分的药物，其在预防和/或治疗与内毒素诱导的细胞内信号传导或细胞活化以及对细胞内信号传导和细胞活化的反应有关的疾病，例如败血症（败血性休克，弥漫性血管内凝血，多器官衰竭等）方面具有优越性。 [解决方案] 一种由通式（I）表示的化合物：其中，X和Y表示与它们结合的碳原子形成环A（环为3-至7成员的杂环或3-至7成员的环烷基环）的基团，每个表示氢原子，或X和Y一起表示环B的取代基。l和m，独立地，表示0至3的整数，且l+m为1至3。R1是脂肪烃基等，可以被从取代基组β和取代基组γ中选择的基团取代。n表示0至3的整数。R2是C1-C6烷基等，可以被从氢原子和取代基组β中选择的基团取代。R3是苯基，5-至6成员的杂环基等，可以被从取代基组ε中选择的基团取代。R5是C1-C6烷基等，可以被从氢原子和取代基组β中选择的基团取代。但在R3是苯基且可以被从取代基组ε中选择的基团取代的情况下，X和Y表示与它们结合的碳原子形成环A的基团，或X和Y一起表示环B的取代基。