3-[[Diethoxy(oxido)phosphaniumyl]amino]phenol | 1571152-11-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-[[Diethoxy(oxido)phosphaniumyl]amino]phenol
• 英文别名: 3-[[diethoxy(oxido)phosphaniumyl]amino]phenol
• CAS: 1571152-11-8
• 化学式: C₁₀H₁₆NO₄P
• 分子量: 245.215
• InChiKey: QQQHMOXGCUGLQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  73.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  亚磷酸二乙酯 、 3-氨基苯酚 在 碘 作用下， 以 neat (no solvent) 为溶剂， 反应 0.5h， 以79%的产率得到3-[[Diethoxy(oxido)phosphaniumyl]amino]phenol
  参考文献：
  名称：

  Iodine catalyzed solvent-free cross-dehydrogenative coupling of arylamines and H-phosphonates for the synthesis of N-arylphosphoramidates under atmospheric conditions

  摘要：

  Aerobic oxidative coupling of various arylamines and H-phosphonates to the corresponding N-arylphosphoramidates has been achieved under solvent-free conditions using molecular iodine. This protocol works at room temperature furnishing the corresponding P-N coupling products in moderate to high yields. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.064

文献信息

• Iodine catalyzed solvent-free cross-dehydrogenative coupling of arylamines and H-phosphonates for the synthesis of N-arylphosphoramidates under atmospheric conditions
  作者：Bashir Ahmad Dar、Nisar A. Dangroo、Amit Gupta、Aarti Wali、Mohammad Akbar Khuroo、Ram A. Vishwakarma、Baldev Singh

  DOI：10.1016/j.tetlet.2014.01.064

  日期：2014.2

  Aerobic oxidative coupling of various arylamines and H-phosphonates to the corresponding N-arylphosphoramidates has been achieved under solvent-free conditions using molecular iodine. This protocol works at room temperature furnishing the corresponding P-N coupling products in moderate to high yields. (C) 2014 Elsevier Ltd. All rights reserved.