2-(Dodecylamino)propane-1,3-diol | 138969-01-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(Dodecylamino)propane-1,3-diol
• CAS: 138969-01-4
• 化学式: C₁₅H₃₃NO₂
• mdl: MFCD20992404
• 分子量: 259.43
• InChiKey: MSKNATSZRVQUDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS<br/>[FR] NOUVEAUX ANALOGUES SYNTHÉTIQUES DE SPHINGOLIPIDES
  申请人：YISSUM RES DEV CO

  公开号：WO2009060457A1

  公开（公告）日：2009-05-14

  The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.

  本发明提供了新的鞘氨醇类似物，表示为式（II）的化合物。这些新颖的类似物表现出显著的抗癌效果，因此被作为治疗细胞增殖性疾病、神经退行性疾病、与代谢相关的疾病、传染病和免疫相关疾病的药物组合物。该发明还提供了将式（II）的新颖鞘氨醇类似物与额外治疗剂结合的联合组合物和配套工具。
• NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS
  申请人：HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED

  公开号：US20150073003A1

  公开（公告）日：2015-03-12

  The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.

  本发明提供了新的神经酰胺类似物，其被指定为公式（II）化合物。这些新颖的类似物表现出显著的抗癌作用，因此作为治疗细胞增殖性疾病、神经退行性疾病、与代谢相关的疾病、感染性疾病和免疫相关疾病的药物组合物而提供。本发明还提供了将公式（II）的新的神经酰胺类似物与其他治疗剂组合的组合物和套件。
• SYNTHETIC ANALOGS OF SPHINGOLIPIDS
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.

  公开号：EP2217560B1

  公开（公告）日：2016-01-27
• US5068120A
  申请人：——

  公开号：US5068120A

  公开（公告）日：1991-11-26
• US8962891B2
  申请人：——

  公开号：US8962891B2

  公开（公告）日：2015-02-24