N',N'-dimethyl-1,2-diphenylethane-1,2-diamine | 93537-39-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: N',N'-dimethyl-1,2-diphenylethane-1,2-diamine
• CAS: 93537-39-4
• 化学式: C₁₆H₂₀N₂
• mdl: MFCD01708278
• 分子量: 240.34
• InChiKey: OEDXASUOCKHCRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE COMPOUND
  申请人：Kanto Kagaku Kabushiki Kaisha

  公开号：US20130197234A1

  公开（公告）日：2013-08-01

  The present invention relates to methods for producing an optically active amine compound via a highly enantioselective hydrogenation reaction of an imine compound, wherein the imine compound is hydrogenated using a ruthenium metal complex having high catalytic activity and represented by Formula (1) RuXYAB  (1) such as RuBr 2 [(S,S)-xylskewphos][(S,S)-dpen].

  本发明涉及通过高度对映选择性的氢化反应制备光学活性胺化合物的方法，其中使用具有高催化活性的钌金属配合物对亚胺化合物进行氢化，该钌金属配合物由式（1）RuXYAB表示，例如RuBr2[(S,S)-xylskewphos][(S,S)-dpen]。
• PREPARATION OF SITAGLIPTIN INTERMEDIATES
  申请人：Sova Matej

  公开号：US20140213810A1

  公开（公告）日：2014-07-31

  The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.

  本发明涉及手性化合物的制备，尤其涉及制备可用作抗糖尿病药物中间体的手性化合物，优选为西格列汀。
• Method of producing an optically active amine compound by catalytic asymmetric hydrogenation using a ruthenium-diphosphine complex
  申请人：Kanto Kagaku Kabushiki Kaisha

  公开号：EP2623509A1

  公开（公告）日：2013-08-07

  The present invention relates to a method for hydrogenating an imine to an optically active amine using a ruthenium metal complex represented by Formula (1)          RuXYAB     (1) such as RuBr2[(S,S )-xylskewphos][(S,S )-dpen]; A is defined as a diphosphine compound represented by Formula (2), B is defined as a diamine compound represented by Formula (3)

  本发明涉及一种使用由式（1）表示的钌金属配合物将亚胺氢化为光学活性胺的方法 RuXYAB (1) 如 RuBr2[(S,S )-xylskewphos] [(S,S)-dpen]； A 定义为由式（2）表示的二膦化合物、 B 定义为由式（3）表示的二胺化合物
• US9174930B2
  申请人：——

  公开号：US9174930B2

  公开（公告）日：2015-11-03
• [EN] PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF OPTICALLY ACTIVE 3-AMINO-1-(2-THIENYL)-1-PROPANOL DERIVATIVES<br/>[FR] PROCEDES ET PRODUITS INTERMEDIAIRES POUR LA PREPARATION DE DERIVES DE 3-AMINO-1-(2-THIENYL)-1-PROPANOL OPTIQUEMENT ACTIFS
  申请人：LONZA AG

  公开号：WO2004031168A2

  公开（公告）日：2004-04-15

  Enantiomerically enriched 3-amino-1-(2-thienyl)-1-propanols of the formulae ((S)-I) or ((R)-I) wherein R1 and R2 independently denote H, C1-6-alkyl, C5-7-cycloalkyl, aralkyl or aryl, were prepared by reducing a 3-amino-1-(2-thienyl)-1-propanone of the formula (II) wherein R1 and R2 are defined as above, using a hydrogen donor in the presence of a metal catalyst, an optically active nitrogen-containing ligand and optionally a base.