N-(1-naphthyl)-1-naphthalenecarboxamide | 5439-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(1-naphthyl)-1-naphthalenecarboxamide
• 英文别名: N-(naphthalen-1-yl)-1-naphthamide；N-[1]naphthyl-[1]naphthamide；N-[1]Naphthyl-[1]naphthamid；α-Naphthoesaeure-α-naphthylamid；n-(1-Naphthyl)-1-naphthamide；N-naphthalen-1-ylnaphthalene-1-carboxamide
• CAS: 5439-52-1
• 化学式: C₂₁H₁₅NO
• 分子量: 297.356
• InChiKey: OAJJHQSXKMOPJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N-(1-naphthyl)-1-naphthalenecarboxamide 在 tetraphosphorus decasulfide 、 potassium sulfide 作用下， 以 甲苯 为溶剂， 以9%的产率得到Naphthalene-1-carbothioic acid naphthalen-1-ylamide
  参考文献：
  名称：

  Mueller, Annerose; Sulej, Helga; Weber, Siegfried, Zeitschrift fur Chemie, 1985, vol. 25, # 1, p. 23 - 24

  摘要：

  DOI：
• 作为产物：
  描述：

  1-萘甲酸 在 五氯化磷 作用下， 生成 N-(1-naphthyl)-1-naphthalenecarboxamide
  参考文献：
  名称：

  Hofmann,A.W., Chemische Berichte, 1868, vol. 1, p. 42

  摘要：

  DOI：

文献信息

• Palladium‐Catalyzed Annulation of Arylbenzamides with Diaryliodonium Salts
  作者：Cheng Pan、Limin Wang、Jianwei Han

  DOI：10.1002/adsc.202100860

  日期：2022.1.18

  By using diaryliodonium salts, a cylization has been accomplished in the synthesis of N-aryl phenanthridinone derivatives via a cascade of ortho-arylation and Csp2-N bond formation in the presence of palladium catalyst. The reaction exhibits a broad compatibility of readily available N-arylnaphthamides.

  通过使用二芳基碘鎓盐，在钯催化剂的存在下，通过邻位芳基化和C sp 2 -N 键形成的级联，在合成N-芳基菲啶酮衍生物中实现了环化。该反应表现出易于获得的N-芳基萘酰胺的广泛相容性。
• 10.1021/acs.orglett.4c01805
  作者：Li, Hao-Yuan、Niu, Xiaoying、Zhang, Shan-Shan、Shen, Shigang、Meng, Qing-Yuan、Yang, Xiu-Long

  DOI：10.1021/acs.orglett.4c01805

  日期：——

  Here, we explore a dehydrogenative 6π photocyclization method for N-substituted naphthalene carboxamides, which can be conducted in air. This method employs DMSO as both the reaction solvent and oxidant while also stabilizing the excited state of the substrate. Furthermore, the addition of photosensitizer enables the reaction to proceed under a 440–445 nm LED source via energy transfer. The proposed

  在这里，我们探索了一种N-取代萘甲酰胺的脱氢6π光环化方法，该方法可以在空气中进行。该方法采用DMSO作为反应溶剂和氧化剂，同时稳定底物的激发态。此外，光敏剂的添加使反应能够在 440-445 nm LED 光源下通过能量转移进行。所提出的机制最初通过 DFT 计算得到验证。
• Angiotensin-Converting Enzyme Inhibitor Angioedema of the Intestine: A Case Report and Review of the Literature
  作者：Troy D. Schmidt、Kevin M. McGrath

  DOI：10.1097/00000441-200208000-00011

  日期：2002.8

  Visceral angioedema is a rare complication of angiotensin-converting enzyme (ACE) inhibitor use. To date, 15 cases have been reported in the literature. Common presentation is that of a middle-aged woman with abdominal pain, emesis, and diarrhea who has recently begun taking an ACE inhibitor. Signs include leukocytosis, ascites, and edematous small bowel seen on computed tomography. Diagnosis is elusive, and frequently invasive procedures, including surgery, are pursued. These can be avoided if the astute physician recognizes the association and withdraws the offending medication. We present the typical diagnostic dilemma faced in the evaluation of a patient with ACE inhibitor angioedema of the intestine, and review the current available literature.
• The Thermal Breakdown of Diaryltetrazoles
  作者：Peter A. S. Smith、Edward Leon

  DOI：10.1021/ja01550a059

  日期：1958.9
• Experiments towards the preparation of some binaphthalene derivatives
  作者：Jerald S. Bradshaw、Ljubo Golič、Miha Tišler

  DOI：10.1007/bf00810258

  日期：1988.3