(1,1,2-trimethyl-propyl)-phosphonic acid-dichloride | 89980-61-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: (1,1,2-trimethyl-propyl)-phosphonic acid-dichloride
• 英文别名: (1,1,2-Trimethyl-propyl)-phosphonsaeure-dichlorid；1,1,2-Trimethyl-propylphosphonsaeure-dichlorid；2-Dichlorophosphoryl-2,3-dimethylbutane；2-dichlorophosphoryl-2,3-dimethylbutane
• CAS: 89980-61-0
• 化学式: C₆H₁₃Cl₂OP
• 分子量: 203.048
• InChiKey: VDNZCCOOJZCBDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1.1.2-Trimethyl-propylmagnesiumchlorid 在 氧气 、 三氯化磷 作用下， 以 四氯化碳 为溶剂， 生成 (1,1,2-trimethyl-propyl)-phosphonic acid-dichloride
  参考文献：
  名称：

  Highly Branched Alkylphosphorus Compounds. II. Synthesis of 1,1,2-Trimethylpropylphosphonyl Chloride¹

  摘要：

  DOI：

  10.1021/jo01026a026

文献信息

• Integrins in Head and Neck Squamous Cell Carcinoma Invasion
  作者：Orville H. Dyce、Amy F. Ziober、Randal S. Weber、Kaoru Miyazaki、Samir S. Khariwala、Michael Feldman、Barry L. Ziober

  DOI：10.1097/00005537-200211000-00021

  日期：2002.11

  AbstractObjective To relate the invasive properties of different squamous cell cancer cell lines to the function and expression of the integrins.Study Design A series of in vitro and in vivo experiments were designed to assess and compare integrin expression and function in two different head and neck squamous cell carcinoma cell lines.Methods Invasive properties of two squamous cell carcinoma cell lines (UM‐SCC‐1 and JHU‐022‐SCC) were assessed using an in vitro artificial matrix assay as well as an in vivo system with orthotopically implanted tumor cells in mice. Whole cell and surface expression levels of integrin subunits (alpha2, alpha3, alpha5, alpha6, beta1, and beta4) were determined for each cell line using Western blot analysis and flow cytometry. We compared the ability of JHU‐022‐SCC and UM‐SCC‐1 cells to bind the extracellular matrix elements collagen IV, fibronectin, laminin 5, and laminin10 using an in vitro adhesion assay. Contributions of the different integrins to the adhesive properties were determined by selective antibody blocking of different subunits.Results The UM‐SCC‐1 cell line is 50% more invasive in vitro and displays a greater propensity for perineural and lymphatic invasion in vivo. The UM‐SCC‐1 cells exhibited greater adherence to fibronectin than JHU‐022‐SCC cells. Alpha6 and beta4 expression is approximately twofold greater in the JHU‐022‐SCC cells. Alpha2, alpha3, and beta1 expression appears to be upregulated in UM‐SCC‐1 cells.Conclusion The UM‐SCC‐1 carcinoma cells are more invasive than JHU‐022‐SCC cells and may be related to differential expression of the integrins alpha6beta4, alpha3beta1, and alpha2beta1.
• Soborowskii et al., Doklady Akademii Nauk SSSR, 1950, vol. 73, p. 333,334
  作者：Soborowskii et al.

  DOI：——

  日期：——
• A Study of the Reaction of Hydrocarbons with Phosphorus Trichloride and Oxygen¹
  作者：A. Furman Isbell、F. T. Wadsworth

  DOI：10.1021/ja01604a025

  日期：1956.12
• VERFAHREN ZUR HERSTELLUNG VON CYCLISCHEN PHOSPHONS UREANHYDR IDEN
  申请人：Archimica GmbH

  公开号：EP1658299B1

  公开（公告）日：2009-09-23
• Highly Branched Alkylphosphorus Compounds. II. Synthesis of 1,1,2-Trimethylpropylphosphonyl Chloride¹
  作者：Sidney H. Metzger、Ottokar H. Basedow、A. F. Isbell

  DOI：10.1021/jo01026a026

  日期：1964.3