cis/trans-1,2-bis-aminomethylcyclohexane | 797038-82-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: cis/trans-1,2-bis-aminomethylcyclohexane
• 英文别名: 1,2-bis(aminomethyl)cyclohexane；1,2-bis-aminomethylcyclohexane；1,2-Di(aminomethyl)cyclohexane；[2-(aminomethyl)cyclohexyl]methanamine
• CAS: 797038-82-5
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: BDYVWDMHYNGVGE-UHFFFAOYSA-N

物化性质

• 沸点：
  216.3±8.0 °C(Predicted)
• 密度：
  0.912±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cis/trans-1,2-bis-aminomethylcyclohexane 以 邻二氯苯 为溶剂， 80.0~250.0 ℃ 、8.0 MPa 条件下， 反应 22.0h， 生成 cyclohexane-1,2-diylbis(methylene) diisocyanate
  参考文献：
  名称：

  METHOD FOR PRODUCING CARBAMATE AND METHOD FOR PRODUCING ISOCYANATE

  摘要：

  本发明提供了一种生产碳酸酯的方法，包括以下步骤：(1)通过使用每个分子至少含有一个一次氨基团的有机初级胺和碳酸气体或碳酸衍生物中选择的至少一种化合物，在低于尿素键热解温度的温度下，生产具有尿素键的化合物(A)；以及(2)将化合物(A)与碳酸酯反应以生产碳酸酯。

  公开号：

  US20210179548A1
• 作为产物：
  描述：

  1,2-二氰基苯 生成 cis/trans-1,2-bis-aminomethylcyclohexane
  参考文献：
  名称：

  METHOD OF CONVEYING LIQUIDS

  摘要：

  本发明涉及一种连续输送化学反应中用作起始物料的液体的方法，该方法采用位移泵，该泵具有物理上分离的正向输送阀和液体填充的双向流动管路，其中在双向流动管路中存在一种辅助液体，该液体是化学反应的产物或起始物料，并且其熔点低于被输送的液体的熔点或饱和温度。 本发明还提供了将芳香化合物氢化生成的产物用作辅助液体输送芳香化合物的用途，以及将醇或由醇和羧酸衍生的酯用作辅助液体输送羧酸或羧酸衍生物的用途。

  公开号：

  US20120116099A1

文献信息

• METHOD FOR PRODUCING CIS- AND TRANS-ENRICHED MDACH
  申请人：BASF SE

  公开号：US20170260115A1

  公开（公告）日：2017-09-14

  A process for preparing trans-enriched MDACH, including: distilling an MDACH starting mixture in the presence of an auxiliary, which is an organic compound having a molar mass of 62 to 500 g/mol, a boiling point at least 5° C. above the boiling point of cis,cis-2,6-diamino-1-methylcyclohexane, and 2 to 4 functional groups, each of which is independently an alcohol group or a primary, secondary or tertiary amino group. The MDACH starting mixture includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, based on the total amount of MDACH present in the MDACH starting mixture. The MDACH starting mixture includes both trans and cis isomers. Trans-enriched MDACH includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, where the proportion of trans isomers in the mixture is higher than the proportion of trans isomers in the MDACH starting mixture.

  制备富含反式异构体MDACH的方法，包括：在辅助剂的存在下蒸馏MDACH起始混合物，所述辅助剂是一种有着62至500克/摩尔的摩尔质量、沸点至少比顺式、顺式-2,6-二氨基-1-甲基环己烷的沸点高出至少5摄氏度，并且具有2至4个官能团，每个官能团独立地是醇基团或一级、二级或三级氨基团的有机化合物。MDACH起始混合物包括以MDACH起始混合物中MDACH总量为基础的0至100%重量的2,4-MDACH和0至100%重量的2,6-MDACH。MDACH起始混合物包括反式和顺式异构体。富含反式异构体的MDACH包括以2,4-MDACH和2,6-MDACH的0至100%重量为基础，其中混合物中反式异构体的比例高于MDACH起始混合物中反式异构体的比例。
• Non-peptide GnRH agents, methods and intermediates for their preparation
  申请人：Pfizer Inc.

  公开号：US20040010033A1

  公开（公告）日：2004-01-15

  Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

  描述了能够抑制促性腺激素释放激素作用的非肽类GnRH药物。这些化合物及其药用盐、多聚体、前药和活性代谢物适用于治疗哺乳动物的生殖障碍和类固醇激素依赖性肿瘤，以及调节生育能力，其中指示抑制促性腺激素释放。还描述了合成这些化合物和在其制备中有用的中间体的方法。
• MONOETHYLENICALLY UNSATURATED MONOMERS AND USES THEREOF
  申请人：BOSTIK SA

  公开号：US20210179576A1

  公开（公告）日：2021-06-17

  The invention relates to a monoethylenically unsaturated monomer of formula (I), and to the use thereof for producing a polymer. The invention also relates to the polymer obtained by polymerising said monomer, and to the use thereof in a composition for producing coatings.

  该发明涉及一种具有化学式(I)的单乙烯不饱和单体，以及其用于生产聚合物的用途。该发明还涉及通过聚合所述单体而获得的聚合物，以及其在用于生产涂层的组合物中的用途。
• FUNCTIONALIZED HIGHLY BRANCHED MELAMINE-POLYAMINE POLYMERS
  申请人：Peretolchin Maxim

  公开号：US20120252987A1

  公开（公告）日：2012-10-04

  The present invention relates to a method for producing amphiphilic functionalized highly branched melamine-polyamine polymers by condensing melamine and optionally a melamine derivate having at least one different amine having at least two primary amino groups and optionally also with urea and/or at least one urea derivative and/or with at least one at least difunctional diisocyanate or polyisocyanate and/or at least one carbolic acid having at least two carboxyl groups or at least one derivative thereof, optionally quaternizing a portion of the amino groups of the polymer thereby obtained, reacting the polymer thus obtained with at least one compound capable of undergoing a condensation or addition reaction with amino groups, and optionally quaternizing at least part of the amino groups of the polymer obtained in the first step. The invention further relates to the amphiphilic functionalized highly branched melamine-polyamine polymers that can be obtained by the method according to the invention, and to the use thereof as surface active agents.

  本发明涉及一种通过将三聚氰胺和至少一种具有至少两个主要氨基的不同氨基的三聚氰胺衍生物以及可能还包括尿素和/或至少一种尿素衍生物和/或至少一种至少双官能团二异氰酸酯或多异氰酸酯和/或至少一种至少具有两个羧基的羧酸或其衍生物缩合，从而制备含有两性功能化的高支化三聚氰胺-多胺聚合物的方法。可选地，对所获得的聚合物的部分氨基进行季铵化，然后将所获得的聚合物与至少一种能够与氨基发生缩合或加成反应的化合物反应，并可选地对第一步中获得的聚合物的部分氨基进行季铵化。本发明还涉及通过本发明的方法可以获得的含有两性功能化的高支化三聚氰胺-多胺聚合物，以及将其用作表面活性剂的用途。
• POLYIMIDE RESIN
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20160137789A1

  公开（公告）日：2016-05-19

  A polyimide resin contains repeating structural units represented by formulas (1) and (2), wherein the content of the repeating structural unit represented by formula (2) relative to the total of the repeating structural unit represented by formula (1) and the repeating structural unit represented by formula (2) falls within a specific range and the content of the divalent group represented by the following structural formula (B1) falls within a specific range: X 1 represents a tetravalent group containing an alicyclic hydrocarbon structure and having a carbon number of from 4 to 22. X 2 represents a tetravalent group containing an aromatic ring and having a carbon number of from 6 to 22. R 1 and R 2 each independently represent a divalent organic group, and the content of the divalent group represented by the following structural formula (B1) relative to the total of R 1 and R 2 is from 80 to 100 mol %:

  一种聚酰亚胺树脂包含由式（1）和（2）表示的重复结构单元，其中由式（2）表示的重复结构单元相对于由式（1）和（2）表示的重复结构单元的总量落在特定范围内，且由下列结构式（B1）表示的二价基团的含量落在特定范围内：X1代表含有脂环烃结构且碳数为4至22的四价基团。X2代表含有芳香环且碳数为6至22的四价基团。R1和R2各自独立地代表二价有机基团，且由下列结构式（B1）表示的二价基团相对于R1和R2的总量为80至100摩尔%。