1-amino-3,3-dimethylguanidine hydriodide | 33398-73-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-amino-3,3-dimethylguanidine hydriodide
• 英文别名: N'-amino-N,N-dimethyl-guanidine; hydriodide；N'-Amino-N,N-dimethyl-guanidin; Hydrojodid；N'-Amino-N,N-dimethyl-guanidinium-jodid；2-amino-1,1-dimethylguanidine;hydroiodide
• CAS: 33398-73-1
• 化学式: C₃H₁₀N₄*HI
• mdl: MFCD28118569
• 分子量: 230.052
• InChiKey: USVHXCUDFIVGGM-UHFFFAOYSA-N

物化性质

• 熔点：
  188-189 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.99
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  67.6
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-amino-3,3-dimethylguanidine hydriodide 在 盐酸 、 sodium nitrite 作用下， 生成 3-Diazo-1,1-dimethylguanidine
  参考文献：
  名称：

  Jensen,K.A. et al., Acta Chemica Scandinavica (1947), 1966, vol. 20, p. 2795 - 2806

  摘要：

  DOI：
• 作为产物：
  描述：

  S-甲基异硫氨基脲盐酸盐 、 二甲胺 以 甲苯 为溶剂， 生成 1-amino-3,3-dimethylguanidine hydriodide
  参考文献：
  名称：

  2-，4-吡啶和4-喹啉羧酸醛的胍基hy​​dr的合成及生物活性

  摘要：

  使用已知的方法，由S-甲基异硫代-半氨基脲氢碘化物合成了一系列衍生自2-和4-吡啶和4-喹啉羧醛的胍基hy​​dr。该化合物类似于抗癌和抗病毒的硫代半氨基甲酰氮，但几种衍生自4-喹啉羧甲醛的胍基showed酮对小鼠的P388淋巴细胞性白血病没有活性。然而，衍生自所有三个杂环醛的鸟嘌呤hydr酮在大鼠中显示出显着的降血压作用。

  DOI：

  10.1002/jps.2600790615

文献信息

• Jacobsen, Noel W.; Jonge, Ian de, Australian Journal of Chemistry, 1987, vol. 40, # 12, p. 1979 - 1988
  作者：Jacobsen, Noel W.、Jonge, Ian de

  DOI：——

  日期：——
• Cationic antiprotozoal drugs. Trypanocidal activity of 2-(4'-formylphenyl)imidazo[1,2-a]pyridinium guanylhydrazones and related derivatives of quaternary heteroaromatic compounds
  作者：Richard J. Sundberg、Daniel J. Dahlhausen、G. Manikumar、B. Mavunkel、A. Biswas、V. Srinivasan、H. A. Musallam、Willis A. Reid、Arba L. Ager

  DOI：10.1021/jm00163a049

  日期：1990.1

  A series of quaternary 2-phenylimidazo[1,2-a]pyridinum salts has been prepared and evaluated for antiparasitic activity. Primary attention was focused on derivatives with amido, substituted hydrazone, and heterocyclic functionality at the para position of the phenyl substituent. Guanylhydrazones and N-substituted guanylhydrazones of the 4'-formyl-substituted compounds are very active against the blood state Trypanosoma rhodesiense in mice by subcutaneous or oral administration. The most potent compounds attain 100% survival for 30 days at doses of less than 1.0 mg/kg (sc) and greater than 5.0 mg/kg (po). Weaker activity is noted for certain other 4'-substituents such as carboxamidines and carboxamide oximes. Considerable variation in structure, including replacing of the imidazo [1,2-a]pyridinium ring by other cationic heterocyclic rings and insertion of linking groups between the heterocyclic ring and phenyl group, can be done, and a high level of activity is maintained. Relationships between these structural changes and biological activity are discussed.
• Miyamoto, Yoshiko, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 7, p. 2678 - 2687
  作者：Miyamoto, Yoshiko

  DOI：——

  日期：——
• Gut,J. et al., Collection of Czechoslovak Chemical Communications, 1966, vol. 31, p. 2014 - 2024
  作者：Gut,J. et al.

  DOI：——

  日期：——
• Schmidpeter, Alfred; Tautz, Helmut, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1980, vol. 35, # 10, p. 1222 - 1228
  作者：Schmidpeter, Alfred、Tautz, Helmut

  DOI：——

  日期：——