5-(4-Hydroxyphenoxy)pentanal | 1005008-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(4-Hydroxyphenoxy)pentanal
• CAS: 1005008-20-7
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: BJLJLONAJCWGHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲醇 、 5-(4-Hydroxyphenoxy)pentanal 在 (R)-2-(dinaphthalen-2-yl-trimethylsilyloxymethyl)pyrrolidine 碘苯二乙酸 作用下， 反应 48.17h， 生成 9a-methoxy-7-oxo-2,3,4,5,5a,6-hexahydro-1-benzoxepine-5-carbaldehyde 、
  参考文献：
  名称：

  An Enantioselective Organocatalytic Oxidative Dearomatization Strategy

  摘要：

  We have developed a catalytic enantioselective strategy for chemical synthesis wherein flat aromatic molecules are directly converted to complex nonremmic molecular arch lectures. The process Involves oxidative dearomatization of substituted phenols followed by a desymmebrizing secondry amine-catalyzed asymmetric intermolecular Michael addition and reveals a declin structure formed with exquisite control of three now streogenic centers and an array of exploitable orthogonal functionality directly from a flat molecule that is devoid or architectural complexity.

  DOI：

  10.1021/ja077457u

文献信息

• An Enantioselective Organocatalytic Oxidative Dearomatization Strategy
  作者：Ngoc T. Vo、Robert D. M. Pace、Fionn O'Har、Matthew J. Gaunt

  DOI：10.1021/ja077457u

  日期：2008.1.1

  We have developed a catalytic enantioselective strategy for chemical synthesis wherein flat aromatic molecules are directly converted to complex nonremmic molecular arch lectures. The process Involves oxidative dearomatization of substituted phenols followed by a desymmebrizing secondry amine-catalyzed asymmetric intermolecular Michael addition and reveals a declin structure formed with exquisite control of three now streogenic centers and an array of exploitable orthogonal functionality directly from a flat molecule that is devoid or architectural complexity.