1,3,6,8-tetraacetoxy-xanthen-9-one | 110144-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1,3,6,8-tetraacetoxy-xanthen-9-one
• 英文别名: 1,3,6,8-Tetraacetoxy-xanthen-9-on；(1,6,8-Triacetyloxy-9-oxoxanthen-3-yl) acetate
• CAS: 110144-75-7
• 化学式: C₂₁H₁₆O₁₀
• 分子量: 428.352
• InChiKey: BZNPMRZKTCPIHE-UHFFFAOYSA-N

物化性质

• 沸点：
  603.6±55.0 °C(Predicted)
• 密度：
  1.408±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  132
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  1,3,6,8-tetraacetoxy-xanthen-9-one 在 盐酸 作用下， 生成 1,3,6,8‐tetrahydroxy‐9H‐xanthen‐9‐one
  参考文献：
  名称：

  Tanase, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1941, vol. 61, p. 341,346

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4,6-三羟基苯甲酸 在 PPA 、 sodium acetate 作用下， 生成 1,3,6,8-tetraacetoxy-xanthen-9-one
  参考文献：
  名称：

  Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitors

  摘要：

  Considerable interest has been attracted in xanthone and its derivatives because of their large variety of pharmacological activities. In this project, a series of hydroxylxanthones and their aectoxy and alkoxy derivatives were synthesized and evaluated as alpha-glucosidase inhibitors, aimed at clarifying the structure-activity correlation. The results indicated that these xanthone derivatives were capable of inhibiting in vitro alpha-glucosidase with moderate to good activities. Among them, polyhydroxylxanthones exhibited the highest activities and thus may be exploitable as a lead compound for the development of potent alpha-glucosidase inhibitors. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.04.014

文献信息

• Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitors
  作者：Yan Liu、Lan Zou、Lin Ma、Wen-Hua Chen、Bo Wang、Zun-Le Xu

  DOI：10.1016/j.bmc.2006.04.014

  日期：2006.8

  Considerable interest has been attracted in xanthone and its derivatives because of their large variety of pharmacological activities. In this project, a series of hydroxylxanthones and their aectoxy and alkoxy derivatives were synthesized and evaluated as alpha-glucosidase inhibitors, aimed at clarifying the structure-activity correlation. The results indicated that these xanthone derivatives were capable of inhibiting in vitro alpha-glucosidase with moderate to good activities. Among them, polyhydroxylxanthones exhibited the highest activities and thus may be exploitable as a lead compound for the development of potent alpha-glucosidase inhibitors. (c) 2006 Elsevier Ltd. All rights reserved.
• Tanase, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1941, vol. 61, p. 341,346
  作者：Tanase

  DOI：——

  日期：——