1-hydroxy-heptane-1,1-bisphosphonate | 56375-74-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 1-hydroxy-heptane-1,1-bisphosphonate
• 英文别名: 1-hydroxyheptane-1,1-diphosphonic acid；(1-Hydroxyheptane-1,1-Diyl)bis(Phosphonic Acid)；(1-hydroxy-1-phosphonoheptyl)phosphonic acid
• CAS: 56375-74-7
• 化学式: C₇H₁₈O₇P₂
• 分子量: 276.163
• InChiKey: IJEGNOYPWRBKAE-UHFFFAOYSA-N

物化性质

• 沸点：
  538.1±60.0 °C(Predicted)
• 密度：
  1.534±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  135
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  庚酸 在 P₄O₆ 作用下， 生成 1-hydroxy-heptane-1,1-bisphosphonate
  参考文献：
  名称：

  Schuelke, Ulrich, Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 51/52, p. 623 - 626

  摘要：

  DOI：

文献信息

• Oligomeric ester chain condensates of substituted
  申请人：Betz Laboratories, Inc.

  公开号：US04190615A1

  公开（公告）日：1980-02-26

  Phosphonic acid ester condensate oligomers are disclosed which are oligomeric ester condensates of alkyl-1-hydroxy-1,1-diphosphonic acid having the formula: ##STR1## where R.sub.1 and R.sub.2 each represent a group having the formula C.sub.x H.sub.2x+1, where x is from 6 to 13; Y is ##STR2## or hydrogen; M is a water soluble cation such as Na, K or NH.sub.4, and n is 1 or greater. The use of these materials as reverse emulsion breakers is also disclosed, as is a method for their preparation.

  揭示了磷酸酯缩聚物，其为烷基-1-羟基-1,1-二膦酸的寡聚酯缩聚物，其化学式为：其中R.sub.1和R.sub.2分别表示具有化学式C.sub.x H.sub.2x+1的基团，其中x为6至13；Y为##STR2##或氢；M为水溶性阳离子，如Na、K或NH.sub.4，n为1或更大。还揭示了将这些材料用作反乳化剂破解剂的用途，以及它们的制备方法。
• Method for preparing oligomeric ester chain condensates of substituted
  申请人：Betz Laboratories, Inc.

  公开号：US04254063A1

  公开（公告）日：1981-03-03

  A method is disclosed for preparing organo-phosphorous compounds which are oligomeric ester condensates of alkyl-1-hydroxy-1,1-diphosphonic acid.

  揭示了一种制备有机磷化合物的方法，这些化合物是烷基-1-羟基-1,1-二膦酸的寡聚酯缩合物。
• FLAME RETARDANT FOR WOODY MATERIALS AND FLAME-RETARDANT WOODY MATERIAL
  申请人：Daihachi Chemical Industry Co., Ltd.

  公开号：EP3633012A1

  公开（公告）日：2020-04-08

  An object of the present invention is to provide a flame-retardant woody material having low hygroscopicity and excellent flame-retardant performance, and a flame retardant for woody materials therefor. The present invention relates to a flame retardant for woody materials comprising an organic phosphorus compound represented by the following formula (1) and a nitrogen compound represented by the following formula (2); and also relates to a flame-retardant woody material comprising a woody material fireproofed with the flame retardant for woody materials: wherein in the formula (1), R1 and R2 are the same or different, and each represents a hydrogen atom, hydroxy, or the like; n is an integer of 1 to 4; X1 and X2 are the same or different, and each represents a hydrogen atom, hydroxy, or the like; and wherein in the formula (2), R3, R4, R5, R6, and R7 are the same or different, and each represents a hydrogen atom, methyl, or the like.

  本发明的目的是提供一种具有低吸湿性和优异阻燃性能的阻燃木质材料及其阻燃剂。本发明涉及一种木质材料用阻燃剂，它由下式（1）代表的有机磷化合物和下式（2）代表的氮化合物组成；还涉及一种阻燃木质材料，它包括用该木质材料用阻燃剂防火的木质材料： 式（1）中，R1 和 R2 相同或不同，各自代表氢原子、羟基或类似物；n 是 1 至 4 的整数；X1 和 X2 相同或不同，各自代表氢原子、羟基或类似物；以及 式（2）中，R3、R4、R5、R6 和 R7 相同或不同，各自代表氢原子、甲基或类似物。
• Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi
  作者：Sergio H. Szajnman、Brian N. Bailey、Roberto Docampo、Juan B. Rodriguez

  DOI：10.1016/s0960-894x(01)00057-9

  日期：2001.3

  We have investigated the effect of a series of bisphosphonates derived from fatty acids against Trypanosoma cruzi proliferation in in vitro assays. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption, their potential innocuousness makes them good candidates to control tropical diseases. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Effects of Bisphosphonates on the Growth of <i>Entamoeba histolytica</i> and <i>Plasmodium </i>Species in Vitro and in Vivo
  作者：Subhash Ghosh、Julian M. W. Chan、Christopher R. Lea、Gary A. Meints、Jared C. Lewis、Zev S. Tovian、Ryan M. Flessner、Timothy C. Loftus、Iris Bruchhaus、Howard Kendrick、Simon L. Croft、Robert G. Kemp、Seiki Kobayashi、Tomoyoshi Nozaki、Eric Oldfield

  DOI：10.1021/jm030084x

  日期：2004.1.1

  The effects of a series of 102 bisphosphonates on the inhibition of growth of Entamoeba histolytica and Plasmodium falciparum in vitro have been determined, and selected compounds were further investigated for their in vivo activity. Forty-seven compounds tested were active (IC50 < 200 muM) versus E. histolytica growth in vitro. The most active compounds (IC50 similar to 4-9 muM) were nitrogen-containing bisphosphonates with relatively large aromatic side chains. Simple n-alkyl-1-hydroxy-1,1-bisphosphonates, known inhibitors of the enzyme farnesylpyrophosphate (FPP) synthase, were also active, with optimal activity being found with C9-C10 side chains. However, numerous other nitrogen-containing bisphosphonates known to be potent FPP synthase inhibitors, such as risedronate or pamidronate, had little or no activity. Several pyridine-derived bisphosphonates were quite active (IC50 similar to 10-20 muM), and this activity was shown to correlate with the basicity of the aromatic group, with activity decreasing with increasing pK(a) values. The activities of all compounds were tested versus a human nasopharyngeal carcinoma (KB) cell line to enable an estimate of the therapeutic index (TI). Five bisphosphonates were selected and then screened for their ability to delay the development of amebic liver abscess formation in an E. histolytica infected hamster model. Two compounds were found to decrease liver abscess formation at 10 mg/kg ip with little or no effect on normal liver mass. With P. falciparum, 35 compounds had IC50 values <200 muM in an in vitro assay. The most active compounds were also simple n-alkyl-1-hydroxy-1,1-bisphosphonates, having IC50 values around 1 muM. Five compounds were again selected for in vivo investigation in a Plasmodium berghei ANKA BALB/c mouse suppressive test. The most active compound, a C9 n-alkyl side chain containing bisphosphonate, caused an 80% reduction in parasitemia with no overt toxicity. Taken together, these results show that bisphosphonates appear to be useful lead compounds for the development of novel antiamebic and antimalarial drugs.