2,3-Dihydro-5-hydroxy-2-methyl-7-pentyl-4H-1-benzopyran-4-one | 95331-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,3-Dihydro-5-hydroxy-2-methyl-7-pentyl-4H-1-benzopyran-4-one
• 英文别名: 5-hydroxy-2-methyl-7-pentyl-2,3-dihydrochromen-4-one
• CAS: 95331-77-4
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: SFTRQPJQTMKBFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-(-)-1-氨基-2-丙醇 、 2,3-Dihydro-5-hydroxy-2-methyl-7-pentyl-4H-1-benzopyran-4-one 以 乙醇 为溶剂， 以59%的产率得到4-[(2R)-2-hydroxypropyl]imino-2-methyl-7-pentyl-2,3-dihydrochromen-5-ol
  参考文献：
  名称：

  Synthesis and anticonvulsant and sedative-hypnotic activity of 4-(alkylimino)-2,3-dihydro-4H-1-benzopyrans and benzothiopyrans

  摘要：

  A series of 4-(alkylimino)-5-hydroxy-7-alkyl-2,3-dihydro-4H-1-benzopyrans and -thiopyrans were synthesized and evaluated for anticonvulsant activity. Preliminary screening of these compounds revealed that 2,2-dimethyl-4-[(2-hydroxyalkyl)imino]-5-hydroxy-7-pentyl-2,3- dihydro-4H-1-benzopyrans 19 and 29, the 7-butyl analogue 34, and the corresponding 7-pentyl-4H-1-benzothiopyrans 38 and 39 had the most promising anticonvulsant activity. Synthesis of both enantiomers of 29 and 39 indicated that the R isomers 30 and 40 were the most active and showed very good protection against MES, pentylenetetrazole, and mercaptopropionic acid induced seizures after oral administration in mice. In the Irwin test these compounds showed a generalized depressant activity but at dosages higher than those showing anticonvulsant activity, whereas acute toxicity after oral administration was low (LD50 higher than 400 mg/kg).

  DOI：

  10.1021/jm00172a030
• 作为产物：
  描述：

  2-Methyl-7-pentyl-2,3,7,8-tetrahydro-6H-chromene-4,5-dione 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以60%的产率得到2,3-Dihydro-5-hydroxy-2-methyl-7-pentyl-4H-1-benzopyran-4-one
  参考文献：
  名称：

  Regioselective Synthesis of 5-Hydroxychroman-4-ones

  摘要：

  DOI：

  10.1055/s-1984-30996

文献信息

• ARNOLDI, A., SYNTHESIS, BRO, 1984, N 10, 856-859
  作者：ARNOLDI, A.

  DOI：——

  日期：——
• Synthesis and anticonvulsant and sedative-hypnotic activity of 4-(alkylimino)-2,3-dihydro-4H-1-benzopyrans and benzothiopyrans
  作者：Anna Arnoldi、Alberto Bonsignori、Piero Melloni、Lucio Merlini、Maria Luisa Quadri、Alessandro C. Rossi、Mariella Valsecchi

  DOI：10.1021/jm00172a030

  日期：1990.10

  A series of 4-(alkylimino)-5-hydroxy-7-alkyl-2,3-dihydro-4H-1-benzopyrans and -thiopyrans were synthesized and evaluated for anticonvulsant activity. Preliminary screening of these compounds revealed that 2,2-dimethyl-4-[(2-hydroxyalkyl)imino]-5-hydroxy-7-pentyl-2,3- dihydro-4H-1-benzopyrans 19 and 29, the 7-butyl analogue 34, and the corresponding 7-pentyl-4H-1-benzothiopyrans 38 and 39 had the most promising anticonvulsant activity. Synthesis of both enantiomers of 29 and 39 indicated that the R isomers 30 and 40 were the most active and showed very good protection against MES, pentylenetetrazole, and mercaptopropionic acid induced seizures after oral administration in mice. In the Irwin test these compounds showed a generalized depressant activity but at dosages higher than those showing anticonvulsant activity, whereas acute toxicity after oral administration was low (LD50 higher than 400 mg/kg).
• Regioselective Synthesis of 5-Hydroxychroman-4-ones
  作者：Anna Arnoldi

  DOI：10.1055/s-1984-30996

  日期：——