2-Methoxy-1-phenylethan-1-amine hydrochloride | 1240527-17-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Methoxy-1-phenylethan-1-amine hydrochloride
• 英文别名: 2-methoxy-1-phenylethanamine;hydrochloride
• CAS: 1240527-17-6
• 化学式: C9H14ClNO
• mdl: MFCD16622062
• 分子量: 187.66
• InChiKey: DLMKXYXAHHMDJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.11
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• 2-(1,1'-BIPHENYL)-1H-BENZODIMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS APELIN AND APJ AGONISTS FOR TREATING CARDIOVASCULAR DISEASES
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20200231547A1

  公开（公告）日：2020-07-23

  The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1′-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.