2,3-Dimethyl-2,6-dihydropyrano[3,2-c]pyridin-5-one | 1407491-51-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃吡啶类
• 英文名称: 2,3-Dimethyl-2,6-dihydropyrano[3,2-c]pyridin-5-one
• 英文别名: 2,3-dimethyl-2,6-dihydropyrano[3,2-c]pyridin-5-one
• CAS: 1407491-51-3
• 化学式: C₁₀H₁₁NO₂
• 分子量: 177.203
• InChiKey: MLDBQOHQDXYFJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  反式-2-甲基-2-丁烯醛 、 2,4-二羟基吡啶 在 哌啶 作用下， 以 乙醇 、 水 为溶剂， 反应 0.25h， 以52%的产率得到2,3-Dimethyl-2,6-dihydropyrano[3,2-c]pyridin-5-one
  参考文献：
  名称：

  Electrocyclization of Oxatrienes in the Construction of Structurally Complex Pyranopyridones

  摘要：

  Application of a tandem Knoevenagel/6 pi-electrocyclization sequence is able to produce highly substituted pyranopyridones from moderate to high yields in a one-step reaction. High diasteroselectivity is observed in some cases and was rationalized on the basis of the thermodynamic control of the evidenced reversibility of a 6 pi-electrocyclization reaction. Numerous examples are provided establishing a novel entry in natural product-like structures of pyranopyridone alkaloids.

  DOI：

  10.1021/ol3026457

文献信息

• Electrocyclization of Oxatrienes in the Construction of Structurally Complex Pyranopyridones
  作者：Anna D. Fotiadou、Alexandros L. Zografos

  DOI：10.1021/ol3026457

  日期：2012.11.16

  Application of a tandem Knoevenagel/6 pi-electrocyclization sequence is able to produce highly substituted pyranopyridones from moderate to high yields in a one-step reaction. High diasteroselectivity is observed in some cases and was rationalized on the basis of the thermodynamic control of the evidenced reversibility of a 6 pi-electrocyclization reaction. Numerous examples are provided establishing a novel entry in natural product-like structures of pyranopyridone alkaloids.