3-butyl-2-ethylquinazolin-4(3H)-one | 94418-49-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-butyl-2-ethylquinazolin-4(3H)-one
• 英文别名: 3-butyl-2-ethylquinazolin-4(3Η)-one；4-Quinazolone, 3-butyl-2-ethyl；3-butyl-2-ethylquinazolin-4-one
• CAS: 94418-49-2
• 化学式: C₁₄H₁₈N₂O
• 分子量: 230.31
• InChiKey: QEXSSMRUAXKFHN-UHFFFAOYSA-N

物化性质

• 熔点：
  111 °C
• 沸点：
  359.1±25.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)
• 保留指数：
  1961;1961

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-Butyl-2-propionylamino-benzamide 以 formamide 为溶剂， 反应 0.17h， 生成 3-butyl-2-ethylquinazolin-4(3H)-one
  参考文献：
  名称：

  Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide

  摘要：

  An efficient methodology for the preparation of a series of 2,3-disubstituted-quinazolin-4(3H) -ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4(3H)-ones and other rings. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.114

文献信息

• Auto-Tandem Catalysis with Ruthenium: From <i>o</i> -Aminobenzamides and Allylic Alcohols to Quinazolinones <i>via</i> Redox Isomerization/Acceptorless Dehydrogenation
  作者：Weikang Zhang、Chong Meng、Yan Liu、Yawen Tang、Feng Li

  DOI：10.1002/adsc.201800660

  日期：2018.10.4

  A strategy for the synthesis of quinazolinones via Ru‐catalyzed redox isomerization/acceptorless dehydrogenation was proposed and accomplished. In the presence of a commercially available [(p‐cymene)Cl2]2, a range of desirable products were obtained with o‐aminobenzamides and allylic alcohols as starting materials in moderate to high yields. This strategy is attractive due to high atom efficiency,

  提出并完成了一种通过Ru催化的氧化还原异构化/无受体脱氢合成喹唑啉酮的策略。在可商购的[（对伞花草烯）Cl 2 ] 2的存在下，以邻氨基苯甲酰胺和烯丙醇为起始原料，以中等至高收率获得了一系列理想的产品。由于高原子效率以及最少的化学药品和能源消耗，该策略具有吸引力。
• 一种由烯醇制备喹唑啉酮的方法
  申请人：南京理工大学

  公开号：CN109384731B

  公开（公告）日：2021-10-08

  本发明公开了一种由烯醇制备喹唑啉酮衍生物的方法，反应中采用相对廉价的钌络合物作为催化剂，商品化、容易获得的催化邻氨基苯甲酰胺与烯醇微波反应制备喹唑啉酮。比较先前同类喹唑啉酮合成方法，本发明反应过程不加任何碱，反应溶剂为清洁无毒的四氢呋喃，氢自动转移，反应原子经济性高，副产物只生成水。
• Malhotra, S.; Koul, S. K.; Sharma, R. L., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 937 - 940
  作者：Malhotra, S.、Koul, S. K.、Sharma, R. L.、Anand, K. K.、Gupta, O. P.、Dhar, K. L.

  DOI：——

  日期：——
• MALHOTRA, S.;KOUL, S. K.;SHARMA, R. L.;ANAND, K. K.;GUPTA, O. P.;DHAR, K.+, INDIAN J. CHEM. B., 27,(1988) N0, C. 937-940
  作者：MALHOTRA, S.、KOUL, S. K.、SHARMA, R. L.、ANAND, K. K.、GUPTA, O. P.、DHAR, K.+

  DOI：——

  日期：——
• Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide
  作者：Ioannis K. Kostakis、Abdelhakim Elomri、Elisabeth Seguin、Mauro Iannelli、Thierry Besson

  DOI：10.1016/j.tetlet.2007.07.114

  日期：2007.9

  An efficient methodology for the preparation of a series of 2,3-disubstituted-quinazolin-4(3H) -ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4(3H)-ones and other rings. (c) 2007 Elsevier Ltd. All rights reserved.