9,10-dihydro-9,9-dimethyl-12-((E)-prop-1-en-1-yl)-8H-benzo[a]xanthen-11(12H)-one | 1359826-89-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 9,10-dihydro-9,9-dimethyl-12-((E)-prop-1-en-1-yl)-8H-benzo[a]xanthen-11(12H)-one
• 英文别名: 9,9-dimethyl-12-[(E)-prop-1-enyl]-10,12-dihydro-8H-benzo[a]xanthen-11-one
• CAS: 1359826-89-3
• 化学式: C₂₂H₂₂O₂
• 分子量: 318.415
• InChiKey: SLRYYDGYXMRTEH-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  巴豆醛 、 5,5-二甲基-1,3-环己二酮 、 2-萘酚 在 HY zeolite catalyst 作用下， 反应 4.0h， 以70%的产率得到9,10-dihydro-9,9-dimethyl-12-((E)-prop-1-en-1-yl)-8H-benzo[a]xanthen-11(12H)-one
  参考文献：
  名称：

  A multicomponent, solvent-free, one-pot synthesis of benzoxanthenones catalyzed by HY zeolite: their anti-microbial and cell imaging studies

  摘要：

  An atom-economical, multicomponent condensation of naphthols, aldehydes, and cyclic 1,3-dicarbonyl compounds catalyzed by HY zeolites under solvent-free conditions is reported. This ecofriendly protocol offers several advantages such as a green and cost-effective procedure with excellent yield, shorter reaction time, simpler work-up, recovery, and reusability of metal-free solid acid heterogeneous catalyst and tolerance of a wide range of functional groups. The biological studies such as in vitro anti-microbial activities of the prepared new compounds and cell imaging studies on K562 leukemia cell lines by selected benzoxanthenones are evaluated. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.143

文献信息

• A multicomponent, solvent-free, one-pot synthesis of benzoxanthenones catalyzed by HY zeolite: their anti-microbial and cell imaging studies
  作者：Velladurai Rama、Kuppusamy Kanagaraj、Kasi Pitchumani

  DOI：10.1016/j.tetlet.2011.10.143

  日期：2012.2

  An atom-economical, multicomponent condensation of naphthols, aldehydes, and cyclic 1,3-dicarbonyl compounds catalyzed by HY zeolites under solvent-free conditions is reported. This ecofriendly protocol offers several advantages such as a green and cost-effective procedure with excellent yield, shorter reaction time, simpler work-up, recovery, and reusability of metal-free solid acid heterogeneous catalyst and tolerance of a wide range of functional groups. The biological studies such as in vitro anti-microbial activities of the prepared new compounds and cell imaging studies on K562 leukemia cell lines by selected benzoxanthenones are evaluated. (C) 2011 Elsevier Ltd. All rights reserved.