4-(2,4-dihydroxy-phenyl)-butyric acid | 78196-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(2,4-dihydroxy-phenyl)-butyric acid
• 英文别名: 4-(2,4-Dihydroxy-phenyl)-buttersaeure；3-(2.4-Dioxy-phenyl)-propan-carbonsaeure-(1)；γ-(2.4-Dioxy-phenyl)-buttersaeure；4-(2,4-Dihydroxyphenyl)butanoic acid
• CAS: 78196-44-8
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: BLGVZDUARLDEFZ-UHFFFAOYSA-N

物化性质

• 熔点：
  118.5-119.0 °C(Solv: benzene (71-43-2))
• 沸点：
  424.9±14.0 °C(Predicted)
• 密度：
  1.336±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(2,4-dihydroxy-phenyl)-butyric acid 生成 4-(2,4-dihydroxy-phenyl)-butyric acid methyl ester
  参考文献：
  名称：

  Y chromosome microdeletion screening in infertile men

  摘要：

  Molecular analysis of Y-chromosomal microdeletions is routinely performed in the work-up of male infertility, in order to establish a diagnosis and for genetic counseling of the couple, since such microdeletions are transmitted to the male offspring. The review of published data shows that microdeletions are relatively common in patients with azoospermia or severe oligozoospermia, with wide variations in the reported deletion frequency depending mainly on the selection criteria. In general, patients with proximal deletions, involving the AZFa and/or the AZFb region show severe defects of spermatogenesis with a high prevalence of Sertoli cell only syndrome, while deletions of the distal AZFb and of the AZFc region can be compatible with residual spermatogenesis. Microdeletions have been only sporadically found in normozoospermic patients. For the time being the molecular analysis of microdeletions of the Y chromosome is indicated in infertile patients with sperm concentration <5x10(6)/ml and in men undergoing assisted reproduction techniques, since the genetic defect and, most probably, the related infertility problem will be transmitted to the sons.

  DOI：

  10.1007/bf03343791
• 作为产物：
  描述：

  4-(2,4-dihydroxy-phenyl)-4-oxo-butyric acid 在 盐酸 、 amalgamated zinc 作用下， 生成 4-(2,4-dihydroxy-phenyl)-butyric acid
  参考文献：
  名称：

  Acetaldehyde stimulation of the growth of Saccharomyces cerevisiae in the presence of inhibitors found inlignocellulose-to-ethanol fermentations

  摘要：

  在含有抑制浓度的糠醛、乙酸盐和木质纤维素水解物中通常存在的其他化合物的发酵中加入少量乙醛，可显著减少酵母生长的滞后期，并促进乙醇的产生。在通过蒸汽/酸预处理生产的桦木水解物的发酵过程中加入乙醛（0.06 克/升），也能观察到类似的效果。在木质纤维素制乙醇发酵过程中，特别是在通过循环培养液产生高浓度抑制剂的发酵过程中，添加乙醛似乎有可能成为当前培养基解毒程序的低成本替代品（或辅助品）。工业微生物学与生物技术杂志》（2000 年）25 期，104-108 页。

  DOI：

  10.1038/sj.jim.7000031

文献信息

• Computational design of a red fluorophore ligase for site-specific protein labeling in living cells
  作者：Daniel S. Liu、Lucas G. Nivón、Florian Richter、Peter J. Goldman、Thomas J. Deerinck、Jennifer Z. Yao、Douglas Richardson、William S. Phipps、Anne Z. Ye、Mark H. Ellisman、Catherine L. Drennan、David Baker、Alice Y. Ting

  DOI：10.1073/pnas.1404736111

  日期：2014.10.28

  This work establishes a fluorescence labeling method that can be used in living cells to derivatize specific proteins of interest with a small red fluorophore, resorufin. The method has extremely high sequence specificity and is based on a computationally designed fluorophore ligase, derived from Escherichia coli lipoic acid ligase. These results demonstrate the power of computational design to majorly reengineer enzyme specificity. Extensive screening of rationally designed enzyme mutants failed to achieve the same result.

  这项工作建立了一种荧光标记方法，可在活细胞中使用，用小红色荧光素resorufin对感兴趣的特定蛋白进行衍生化。该方法具有极高的序列特异性，基于计算设计的荧光素连接酶，源自大肠杆菌硫辛酸连接酶。这些结果展示了计算设计在重塑酶特异性方面的强大能力。对经过合理设计的酶突变体进行广泛筛选未能达到相同结果。
• 2,7-Dialkylfluorescein derivatives and their use in fluorescence immunoassays
  申请人：SYVA COMPANY

  公开号：EP0025912A1

  公开（公告）日：1981-04-01

  Fluorescent antigen conjugates are provided comprising antigens covalantly bonded to at least one 2,7-dialiphatic substituted-9-phenyl-6-hydroxy-3H-xanthen-3-one, wherein the 1- and 8-positions are unsubstituted. Also provided are novel fluorescent compounds absorbing at wavelengths in excess of 500 nm, having active functionalities for linking to the antigen. Finally, methods are provided for analyzing antigens in serum, whereby serum interference is avoided.

  提供的荧光抗原共轭物包括与至少一种 2,7-二脂肪族取代-9-苯基-6-羟基-3H-氧杂蒽-3-酮共价键合的抗原，其中 1-和 8-位未被取代。 还提供了新型荧光化合物，其吸收波长超过 500 纳米，具有与抗原连接的活性官能团。 最后，提供了分析血清中抗原的方法，从而避免了血清干扰。
• Langley; Adams, Journal of the American Chemical Society, 1922, vol. 44, p. 2327
  作者：Langley、Adams

  DOI：——

  日期：——
• Characterization of novel genes in AZF regions
  作者：L. Stuppia、V. Gatta、I. Fogh、A. R. Gaspari、R. Grande、E. Morizio、D. Fantasia、A. Pizzuti、G. Calabrese、Giandomenico Palka

  DOI：10.1007/bf03343790

  日期：2000.11

  The long arm of the Y chromosome contains genes mapped in loci involved in male infertility, short stature and gonadoblastoma. However, many of these genes have not been fully characterized, and are not currently investigated in patients affected by such diseases. We report a study aimed to the genomic characterization of 5 genes mapped within the Y chromosome: BPY2, PRY, TTY1, TTY2, and VCY. Exon-intron boundaries were detected for each gene, and PCR analysis was carried out to investigate the involvement of these genes in different re-arrangements of the Y chromosome. It was found that BPY2 and PRY are lost in some infertile patients with Yq microdeletions, suggesting that they could play a role in male gametogenesis. On the other hand, these patients retain some copies of TTY1 and TTY2 genes, due to the presence of copies in Yp, and of VCY, which has homologous copies on the X chromosome. On the basis of their localization, these genes could be candidate for the gonadoblastoma locus (TTY1, TTY2) and for the control growth locus (VCY). (C) 2000, Editrice Kurtis.
• Utilisation de dérivés de la resorcine substitués en position(s)4,4 et 5 ou 4 et 6 dans des compositions cosmétiques ou dermopharmaceutiques à action dépigmentante
  申请人：L'OREAL

  公开号：EP0623339B1

  公开（公告）日：1997-07-23