5-Dimethylamino-1-naphthalinthiol | 67101-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-Dimethylamino-1-naphthalinthiol
• 英文别名: 5-(Dimethylamino)naphthalene-1-thiol
• CAS: 67101-61-5
• 化学式: C₁₂H₁₃NS
• 分子量: 203.308
• InChiKey: LNHHFPBFWMCFNF-UHFFFAOYSA-N

物化性质

• 沸点：
  321.9±17.0 °C(Predicted)
• 密度：
  1.167±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  4.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Dimethylamino-1-naphthalinthiol 在 碘 作用下， 以 乙醇 为溶剂， 生成 bis-<5-Dimethylamino-1-naphthyl>-disulfid
  参考文献：
  名称：

  Organic disulfides and related substances. 42. Synthesis and properties of some tertiary disulfides, especially involving penicillamine

  摘要：

  DOI：

  10.1021/jo01329a007
• 作为产物：
  描述：

  丹酰氯 在 汞 、 锌 作用下， 生成 5-Dimethylamino-1-naphthalinthiol
  参考文献：
  名称：

  Organic disulfides and related substances. 42. Synthesis and properties of some tertiary disulfides, especially involving penicillamine

  摘要：

  DOI：

  10.1021/jo01329a007

文献信息

• Two-Photon Fluorescence Probe for Selective Monitoring of Superoxide in Live Cells and Tissues
  作者：Liyan Chen、Myoung Ki Cho、Di Wu、Hwan Myung Kim、Juyoung Yoon

  DOI：10.1021/acs.analchem.9b03937

  日期：2019.11.19

  The abnormal location or generation of superoxide radical anion (O2•–) are implicated in many diseases, including cancers; thus, development of an efficient method to detect O2•– is of great importance. Inspired by the fluorophore-governed selective manner to O2•– and peroxynitrite (ONOO–) of previously reported phosphinate-based fluorescence probes, in this contribution, a phosphinothioate-containing probe, TPP, was designed. The probe exhibited easy accessibility through a one-step sequence and good photostability and biocompatibility. Interestingly, TPP showed high specificity and sensitivity to O2•– over other reactive oxygen species/nitrogen species including ONOO–. Furthermore, with the assistance of two-photon microscopy, TPP was successfully applied for imaging endogenous O2•– in live cells and tissues.

  超氧阴离子自由基(O2•–)的异常分布或产生与许多疾病有关，包括癌症。因此，开发一种高效检测O2•–的方法十分重要。受先前报道的磷酸酯类荧光探针对O2•–和过氧亚硝酸盐(ONOO–)的选择性检测启发，本研究设计了一种含磷硫酸酯的探针TPP。该探针具有单步合成易得性、良好的光稳定性和生物相容性。有趣的是，与其他活性氧/氮物种(包括ONOO–)相比，TPP对O2•–表现出高度特异性和灵敏度。此外，借助双光子显微镜，TPP成功实现了对活细胞和组织中内源性O2•–的成像。
• [EN] PEPTIDE DEFORMYLASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PEPTIDE DEFORMYLASE
  申请人：CHRISTENSEN SIEGFRIED B IV

  公开号：WO2004098584A1

  公开（公告）日：2004-11-18

  Novel PDF inhibitors and novel methods for their use are provided.

  提供了新型PDF抑制剂和其使用的新方法。
• EP1615629A1
  申请人：——

  公开号：EP1615629A1

  公开（公告）日：2006-01-18
• EP1615629A4
  申请人：——

  公开号：EP1615629A4

  公开（公告）日：2007-02-28
• NOVEL POLYAMINE DERIVATIVES
  申请人：Miyake Muneharu

  公开号：US20100063322A1

  公开（公告）日：2010-03-11

  A compound having the general formula (I) or a pharmacologically acceptable salt thereof: X—NH—Y—NH—R 1 (I) [wherein X represents R 2 —SO 2 — in which R 2 represents an optionally substituted lower alkyl group or phenyl group; Y represents a group selected from the group consisting of —R 3 —NH—R 4 —, —R 5 —NH—R 6 —NH—R 7 —, —R 8 —NH—R 9 —NH—R 10 —NH—R 11 — and —R 12 —NH—R 13 —NH—R 14 —NH—R 15 — in which R 3 to R 15 each independently represent a C 3 to C 5 alkylene group; and R 1 represents hydrogen or an optionally substituted lower alkyl group, with the proviso that the case where X represents a tosyl group, Y represents —(CH 2 ) 3 —NH—(CH 2 ) 4 —NH—(CH 2 ) 3 — and R 1 represents hydrogen is excepted].