2-hydroxy-propionaldehyde oxime | 14352-52-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-hydroxy-propionaldehyde oxime
• 英文别名: 1-(Hydroxyimino)propan-2-ol；1-hydroxyiminopropan-2-ol
• CAS: 14352-52-4
• 化学式: C₃H₇NO₂
• 分子量: 89.0941
• InChiKey: QTHGENZSQCEUIG-UHFFFAOYSA-N

物化性质

• 沸点：
  57-58 °C(Press: 1 Torr)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxy-propionaldehyde oxime 在 亚膦酸 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以0.35 g的产率得到(1-Amino-2-hydroxypropyl)phosphonous acid
  参考文献：
  名称：

  New synthesis and fungicidal activity of the phosphine analogues of serine and threonine

  摘要：

  The phosphine analogues of serine and threonine were prepared by the reaction of hydroxyaldehyde oximes with H3PO2, and the acid ester of sulfuric acid and the phosphine analogue of serine was synthesised; the high fungicidal activity of these substances was found for the first time.

  DOI：

  10.1070/mc2005v015n02abeh001940
• 作为产物：
  描述：

  异丙醇胺 在 盐酸 、 sodium tungstate 、 双氧水 作用下， 反应 4.5h， 生成 2-hydroxy-propionaldehyde oxime
  参考文献：
  名称：

  New synthesis and fungicidal activity of the phosphine analogues of serine and threonine

  摘要：

  The phosphine analogues of serine and threonine were prepared by the reaction of hydroxyaldehyde oximes with H3PO2, and the acid ester of sulfuric acid and the phosphine analogue of serine was synthesised; the high fungicidal activity of these substances was found for the first time.

  DOI：

  10.1070/mc2005v015n02abeh001940

文献信息

• The Investigation of the Alkylation Reactions of Hydroxy and En‐Oximes with Some Halohydrins and Epoxides
  作者：Sultan Kurbanlı、Nejdet Şen、Ersin Güler、Ahmet Koçak

  DOI：10.1081/scc-120030754

  日期：2004.12.31

  Abstract Suitable glycol ethers (3a–d, 4a–d) and halohydrine compounds (11a–c) were synthesized in good yield by the alkylation reactions of the oximes, having hydroxy and double bond in its structure, with mono‐ and dihalogenhydrines in the medium of basic and solid–liquid phase transfer catalyst. A series of aminoalcohols were synthesized from these compounds obtained (16a, 17b, 18b).

  摘要 通过结构中具有羟基和双键的肟的烷基化反应，以良好的收率合成了合适的二醇醚（3a-d，4a-d）和卤代醇化合物（11a-c）和单卤代醇和二卤代醇。碱性介质和固液相转移催化剂。由这些获得的化合物合成了一系列氨基醇（16a、17b、18b）。
• New synthesis and fungicidal activity of the phosphine analogues of serine and threonine
  作者：Yurii N. Zhukov、Nelli A. Vavilova、Tat’yana I. Osipova、Elena N. Khurs、Vitaly G. Dzhavakhiya、Radii M. Khomutov

  DOI：10.1070/mc2005v015n02abeh001940

  日期：2005.1

  The phosphine analogues of serine and threonine were prepared by the reaction of hydroxyaldehyde oximes with H3PO2, and the acid ester of sulfuric acid and the phosphine analogue of serine was synthesised; the high fungicidal activity of these substances was found for the first time.