1-(2,3-dihydro-benzo-[1,4]-dioxin-6-yl)-2-phenoxy-ethanone | 133188-50-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 1-(2,3-dihydro-benzo-[1,4]-dioxin-6-yl)-2-phenoxy-ethanone
• 英文别名: 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-phenoxyethanone；1-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-2-phenoxy-ethanone
• CAS: 133188-50-8
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: IGLCNIOKWRSSKV-UHFFFAOYSA-N

物化性质

• 熔点：
  82-83 °C
• 沸点：
  461.2±45.0 °C(Predicted)
• 密度：
  1.238±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2,3-dihydro-benzo-[1,4]-dioxin-6-yl)-2-phenoxy-ethanone 在 lithium aluminium tetrahydride 、 盐酸羟胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 5.0h， 生成 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-phenoxyethylamine
  参考文献：
  名称：

  Discovering Potassium Channel Blockers from Synthetic Compound Database by Using Structure-Based Virtual Screening in Conjunction with Electrophysiological Assay

  摘要：

  Potassium ion (K+) channels are attractive targets for drug discovery because of the essential roles played in biological systems. However, high-throughput screening (HTS) cannot be used to screen K+ channel blockers. To overcome this disadvantage of HTS, we have developed a virtual screening approach for discovering novel blockers of K+ channels. On the basis of a three-dimensional model of the eukaryotic K+ channels, molecular docking-based virtual screening was employed to search the chemical database MDL Available Chemicals Directory (ACD). Compounds were ranked according to their relative binding energy, favorable shape complementarity, and potential to form hydrogen bonds with the outer mouth of the K+ channel model. Twenty candidate compounds selected from the virtual screening were examined using the whole-cell voltage-clamp recording in rat dissociated hippocampal neurons. Among them, six compounds (5, 6, 8, 18-20) potently blocked both the delayed rectifier (I-K) and fast transient K+ currents (I-A). When applied externally, these six compounds preferentially blocked I-K with potencies 2- to 500-fold higher than that of tetraethylammonium chloride. Intracellular application of the six compounds had no effect on both K+ currents. In addition, the interaction models and binding free energy calculations demonstrated that hydrophobic interaction and solvent effects play important roles in the inhibitory activities of these compounds. The results demonstrated that structure-based computer screening strategy could be used to identify novel, structurally diverse compounds targeting the pore binding pocket of the outer mouth of voltage-gated K+ channels. This study provides an alternative way of finding new blockers of voltage-gated K+ channels, while the techniques for high-throughput screening of K+ channel drugs remain in development.

  DOI：

  10.1021/jm060414o
• 作为产物：
  描述：

  2-溴-1-(2,3-二氢-1,4-苯并二氧)乙酮 、 sodium phenoxide 以 四氢呋喃 为溶剂， 反应 3.0h， 以68.6%的产率得到1-(2,3-dihydro-benzo-[1,4]-dioxin-6-yl)-2-phenoxy-ethanone
  参考文献：
  名称：

  Discovering Potassium Channel Blockers from Synthetic Compound Database by Using Structure-Based Virtual Screening in Conjunction with Electrophysiological Assay

  摘要：

  Potassium ion (K+) channels are attractive targets for drug discovery because of the essential roles played in biological systems. However, high-throughput screening (HTS) cannot be used to screen K+ channel blockers. To overcome this disadvantage of HTS, we have developed a virtual screening approach for discovering novel blockers of K+ channels. On the basis of a three-dimensional model of the eukaryotic K+ channels, molecular docking-based virtual screening was employed to search the chemical database MDL Available Chemicals Directory (ACD). Compounds were ranked according to their relative binding energy, favorable shape complementarity, and potential to form hydrogen bonds with the outer mouth of the K+ channel model. Twenty candidate compounds selected from the virtual screening were examined using the whole-cell voltage-clamp recording in rat dissociated hippocampal neurons. Among them, six compounds (5, 6, 8, 18-20) potently blocked both the delayed rectifier (I-K) and fast transient K+ currents (I-A). When applied externally, these six compounds preferentially blocked I-K with potencies 2- to 500-fold higher than that of tetraethylammonium chloride. Intracellular application of the six compounds had no effect on both K+ currents. In addition, the interaction models and binding free energy calculations demonstrated that hydrophobic interaction and solvent effects play important roles in the inhibitory activities of these compounds. The results demonstrated that structure-based computer screening strategy could be used to identify novel, structurally diverse compounds targeting the pore binding pocket of the outer mouth of voltage-gated K+ channels. This study provides an alternative way of finding new blockers of voltage-gated K+ channels, while the techniques for high-throughput screening of K+ channel drugs remain in development.

  DOI：

  10.1021/jm060414o

文献信息

• A Practical and Efficient Route for the Highly Enantioselective Synthesis of Mexiletine Analogues and Novel β-Thiophenoxy and Pyridyl Ethers
  作者：Kun Huang、Margarita Ortiz-Marciales、Viatcheslav Stepanenko、Melvin De Jesús、Wildeliz Correa

  DOI：10.1021/jo801181d

  日期：2008.9.1

  A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues with use of 10% of spiroborate ester 6 as chirality transfer agent is presented. A variety of mexiletine analogues were prepared in good yield with excellent enantioselectivities (91−97% ee) from readily available starting materials. The developed methodology was also successfully applied for the synthesis

  介绍了使用 10% 的螺硼酸酯6作为手性转移剂对美西律类似物进行对映选择性合成的实用且有效的方法。各种美西律类似物以良好的收率和优异的对映选择性（91-97% ee）从容易获得的起始材料中制备。所开发的方法也成功地应用于合成含有苯硫基和吡啶基片段的新型 β-氨基醚。
• Cobalt-Catalyzed Asymmetric Hydrosilylation of α-Oxygenated Ketones
  作者：Huiting Wen、Yifei Chen、Lanxuan Shi、Jianhui Chen、Yanshu Luo、Yuanzhi Xia

  DOI：10.1021/acs.orglett.3c00162

  日期：——

  An asymmetric hydrosilylation of α-oxygenated ketones was developed under the catalysis of Co(OAc)2 in combination with a chiral phosphine-amido-oxazoline (PAO) ligand, providing a mild, efficient, and enantioselective access to a variety of synthetically useful 1,2-diol derivatives. This protocol can be carried out at the gram scale with a catalyst loading of 1 mol %, and its synthetic utility was

  在 Co(OAc) 2与手性膦-氨基-恶唑啉 (PAO)配体结合的催化下，开发了 α-氧化酮的不对称氢化硅烷化反应，提供了一种温和、高效和对映选择性的方法，可用于合成各种有用的化合物 1 ,2-二醇衍生物。该方案可以在克级进行，催化剂负载量为 1 mol%，其合成效用通过将光学富集产品有效转化为手性 α-羟基酸、1,3-dioxolan-2-one、环氧乙烷和 1,2,3-1 H-三唑。
• US8012901B1
  申请人：——

  公开号：US8012901B1

  公开（公告）日：2011-09-06