N-Hydroxytyramin | 193021-75-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-Hydroxytyramin
• 英文别名: 4-[2-(Hydroxyamino)ethyl]phenol
• CAS: 193021-75-9
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: WPFZZGBOOZDRBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Hydroxylamine derivatives
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1541547A1

  公开（公告）日：2005-06-15

  This invention is related to hydroxylamino derivatives of the following general formula (I) wherein    n is 0, 1 or 2;    R1 and R2, independently of each other, are H, OH or OCH3;    R3 is H or CH3;    R4 is H, C1-C3 straight or branched alkyl or, together with R3, forms a five to seven-membered carbocyclic ring;    and R5 and R6, independently of each other, are H or C1-C5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing said compounds and to pharmaceutical compositions containing them.

  这项发明涉及以下一般式（I）的羟胺衍生物， 其中    n为0、1或2；    R1和R2，彼此独立，为H、OH或OCH3；    R3为H或CH3；    R4为H、C1-C3直链或支链烷基，或者与R3一起形成五至七元碳环；    而R5和R6，彼此独立，为H或C1-C5直链或支链烷基 以及其药学上可接受的盐或前药，用于制备用于预防、治疗和诊断与蛋白质错误折叠和/或错误聚集相关的中枢神经系统退行性疾病的药物。 该发明还涉及包含在式（I）中的新化合物，制备这些化合物的方法以及含有它们的药物组合物。
• Imaging of Enzyme Activity
  申请人：Bogdanov Alexei

  公开号：US20080044827A1

  公开（公告）日：2008-02-21

  This invention relates to biochemistry and magnetic resonance imaging.

  这项发明涉及生物化学和磁共振成像。
• HYDROXYLAMINE DERIVATIVES
  申请人：CACCIA Carla

  公开号：US20100197799A1

  公开（公告）日：2010-08-05

  This invention is related to hydroxylamino derivatives of the following general formula (I) wherein n is 0, 1 or 2; R 1 and R 2 , independently of each other, are H, OH or OCH 3 ; R 3 is H or CH 3 ; R 4 is H, C 1 -C 3 straight or branched alkyl or, together with R 3 , forms a five to seven-membered carbocyclic ring; and R 5 and R 6 , independently of each other, are H or C 1 -C 5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing the compounds and to pharmaceutical compositions containing them.

  本发明涉及以下通式（I）的羟胺衍生物，其中n为0、1或2；R1和R2独立地为H、OH或OCH3；R3为H或CH3；R4为H、C1-C3直链或支链烷基或与R3一起形成五元至七元的碳环；R5和R6独立地为H或C1-C5直链或支链烷基，以及其药学上可接受的盐或前药，用于制备有益于预防、治疗和诊断与蛋白质错折和/或错聚相关的中枢神经系统退行性疾病的药物。本发明还涉及包括式（I）中的新化合物、制备该化合物的方法以及含有它们的药物组合物。
• DIAGNOSTIC TEST AND TREATMENT FOR A NEUROLOGICAL DISORDER
  申请人：Minassian Berge

  公开号：US20140187593A1

  公开（公告）日：2014-07-03

  Methods and compositions relating to diagnosing and treating a VMAT-2 deficiency disease are described. Provided are methods for screening for, diagnosing or detecting a risk of developing a VMAT-2 deficiency disease comprising detecting the presence of a VMAT-2 variant in a sample of a subject, wherein the presence of the VMAT-2 variant is indicative that the subject has a VMAT-2 deficiency disease or an increased risk of developing a VMAT-2 deficiency disease compared to an individual having wild type VMAT-2. Also provided are methods of treating a VMAT-2 deficiency disease with a dopamine agonist.

  本文描述了与诊断和治疗VMAT-2缺陷疾病相关的方法和组合物。提供了筛选、诊断或检测VMAT-2缺陷疾病发展风险的方法，包括检测受试者样本中VMAT-2变异体的存在，其中VMAT-2变异体的存在表明受试者患有VMAT-2缺陷疾病或比具有野生型VMAT-2的个体更容易发展VMAT-2缺陷疾病。还提供了使用多巴胺激动剂治疗VMAT-2缺陷疾病的方法。
• Absorbent for free hemoglobin
  申请人：Japan Medical Supply Co., Ltd.

  公开号：EP0320194A1

  公开（公告）日：1989-06-14

  An absorbent for absorbing free hemoglobin from blood is provided, which comprises a water insoluble porous carrier having phenyl and/or phenol groups on the surface of the carrier. The phenyl and/or phenol groups may be a constituent of the carrier itself, or they may be a constituent of a separate compound affixed to the carrier surface, directly or through use of a coupling agent. Also provided is a method for absorbing free hemoglobin from whole blood or separated plasma which includes contacting the whole blood or plasma with the absorbent.

  本发明提供了一种用于吸收血液中游离血红蛋白的吸收剂，它包括一种不溶于水的多孔载体，载体表面具有苯基和/或苯酚基团。苯基和/或苯酚基团可以是载体本身的成分，也可以是直接或通过使用偶联剂粘附在载体表面的独立化合物的成分。还提供了一种从全血或分离血浆中吸收游离血红蛋白的方法，该方法包括将全血或血浆与吸收剂接触。