N-allyl di-n-octyl amine | 94381-01-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-allyl di-n-octyl amine
• 英文别名: N-allyl-di(n-octylamine)；alllyldioctylamine；N-Allyl-N,N-di-n-octylamine；Dioctyl-allyl-amin；N-octyl-N-prop-2-enyloctan-1-amine
• CAS: 94381-01-8
• 化学式: C₁₉H₃₉N
• 分子量: 281.525
• InChiKey: KTTAXOZHFOSJFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-烯丙基苯并三唑 、 二正辛胺 在 palladium diacetate 、 2-烯丙基-2H-苯并[d] [1,2,3]三唑 、 potassium carbonate 、 三苯基膦 作用下， 以 甲醇 为溶剂， 以87%的产率得到N-allyl di-n-octyl amine
  参考文献：
  名称：

  Palladium-Catalyzed Reaction of N-Allylbenzotriazoles with Amines:  A Novel Method for the Preparation of Allylamines

  摘要：

  DOI：

  10.1021/jo980200h

文献信息

• Use of a bulky phosphine of weak σ-donicity with palladium as a versatile and highly-active catalytic system: allylation and arylation coupling reactions at 10−1–10−4mol% catalyst loadings of ferrocenyl bis(difurylphosphine)/Pd
  作者：Jean-Cyrille Hierso、Aziz Fihri、Régine Amardeil、Philippe Meunier、Henri Doucet、Maurice Santelli

  DOI：10.1016/j.tet.2005.06.065

  日期：2005.10

  (nucleophilic allylation) coupling processes are promoted by a catalytic system containing [PdCl(η3–C3H5)]2 with the new ferrocenyl bis(difurylphosphine) 1,1′-bis[di(5-methyl-2-furyl)phosphino]ferrocene, Fc[P(FuMe)2]2. Starting from aryl bromides or allylic acetates this versatile catalyst system may be used at low palladium loadings (10−1–10−4 mol%) in some Heck, Suzuki, Sonogashira and allylic amination

  碳-碳（SP 2 -SP 2和SP 1 -SP 2）和碳-氮（亲核烯丙基化）耦合过程由含有催化体系促进[的PdCl（η 3 -C 3 H ^ 5）] 2与新的二茂铁基双（二呋喃基膦）1，1'-双[二（5-甲基-2-呋喃基）膦基]二茂铁，Fc [P（Fu Me）2 ] 2。从芳基溴化物或乙酸烯丙酯开始，这种通用的催化剂体系可以在低钯载量下使用（10 -1 –10 -4 摩尔％）在一些Heck，Suzuki，Sonogashira和烯丙基胺化反应中以优异的产率得到交叉偶联的产物。在烯丙基取代反应中获得了显着的高活性，这为该特定反应具有弱的σ-强度的大尺寸膦的发展提供了重要的动力。
• Dramatic acceleration of the catalytic process of the amination of allyl acetates in the presence of a tetraphosphine/palladium system
  作者：Marie Feuerstein、Dorothée Laurenti、Henri Doucet、Maurice Santelli

  DOI：10.1039/b007860n

  日期：——

  The cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)-cyclopentan e/[PdCl(C3H5)]2 system catalyses allylic amination in good yields with a very high substrate/catalyst ratio; a turnover number of 680 000 and a turnover frequency of 8125 h−1 can be obtained for the addition of dipropylamine to allyl acetate in the presence of this catalyst.

  顺式、顺式、顺式-1,2,3,4-四(二苯基膦甲基)环戊烷/[PdCl(C3H5)]2系统在良好的产率下催化烯丙基胺化反应，具有很高的底物/催化剂比率；在该催化剂存在下，将二丙胺加成到乙酸烯丙酯中，可以获得680,000的周转数和8125 h−1的周转频率。
• Dehydrative Allylation of Amine with Allyl Alcohol by Titanium Oxide Supported Molybdenum Oxide Catalyst
  作者：Yoshihiro Kon、Takuya Nakashima、Tadahiro Fujitani、Toru Murayama、Wataru Ueda

  DOI：10.1055/s-0037-1612010

  日期：2019.2

  The dehydrative allylation from allyl alcohol with amines to generate various allyl amines by MoO3/TiO2 solid catalyst is described. The catalyst can be reused at least three times without a decrease of activity.

  描述了在 MoO3/TiO2 固体催化剂下，烯丙醇与胺脱水烯丙基化生成各种烯丙胺。催化剂可重复使用至少3次，活性不降低。
• Resin-immobilised benzyl and aryl vinyl sulfones: New versatile traceless linkers for solid-phase organic synthesis
  作者：Friedrich E.K. Kroll、Richard Morphy、David Rees、David Gani

  DOI：10.1016/s0040-4039(97)10291-x

  日期：1997.12

  New polystyrene-based resins containing benzyl and aryl vinyl sulfone groups are described. The vinyl sulfone group reacts efficiently with 2° amines, via conjugate addition, and the resin-bound 3° amine products can be quatermised through alkylation. Subsequent deamination to give 3° amines and the regenerated vinyl sulfone occurs in moderate to good yield. Both systems can be recycled and show moderate

  描述了含有苄基和芳基乙烯基砜基团的新型聚苯乙烯基树脂。乙烯基砜基团通过共轭加成与2°胺有效反应，与树脂结合的3°胺产物可通过烷基化进行季铵化。随后的脱氨基反应得到3°胺，再生的乙烯基砜以中等至良好的收率发生。两种系统均可循环使用，对酸显示出中等稳定性，对包括格氏试剂在内的亲核试剂显示出高稳定性。
• Solid phase supports
  申请人：——

  公开号：US20030138846A1

  公开（公告）日：2003-07-24

  Embodiments of the present invention generally relate to carrying out organic chemistry on solid supports comprising derivatised functionalities, methods for synthesizing said supports, methods for synthesizing compounds comprising amine groups or N-containing heterocycles using said solid supports, intermediate compounds linked to said supports and uses thereof.

  本发明实施例通常涉及在包含衍生化官能团的固体支持体上进行有机化学反应，合成该支持体的方法，使用该固体支持体合成含有胺基或N-含杂环化合物的方法，与该支持体连接的中间化合物及其用途。