N1-ethyl-N1-(2-methoxyethyl)-1,2-Ethanediamine | 74247-36-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N1-ethyl-N1-(2-methoxyethyl)-1,2-Ethanediamine
• 英文别名: N'-ethyl-N'-(2-methoxyethyl)ethane-1,2-diamine
• CAS: 74247-36-2
• 化学式: C₇H₁₈N₂O
• 分子量: 146.23
• InChiKey: FBQIOVYVRUXKCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Oligomer-Containing Benzamide-Based Compounds
  申请人：NEKTAR THERAPEUTICS

  公开号：US20150250894A1

  公开（公告）日：2015-09-10

  The invention relates to (among other things) oligomer-containing benzamide-based compounds. A compound of the invention exhibits one or more advantages over corresponding compounds lacking the oligomer.

  本发明涉及含寡聚物的苯甲酰胺基化合物等。本发明的化合物相比缺乏寡聚物的相应化合物表现出一种或多种优点。
• Substituted azetidinones as anti-inflammatory and antidegenerative agents
  申请人：MERCK & CO. INC.

  公开号：EP0525973A2

  公开（公告）日：1993-02-03

  New substituted azetidinones of the general formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described.

  本文描述了通式（I）的新取代氮杂环丁酮，发现它们是有效的弹性蛋白酶抑制剂，因此是有用的抗炎剂和抗变性剂。
• Inhibitors of histone deacetylase
  申请人：MethylGene Inc.

  公开号：EP2489657A2

  公开（公告）日：2012-08-22

  This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein (B), Q, J, L and Z are as defined in the specification.

  本发明涉及抑制组蛋白去乙酰化酶的化合物。更具体地说，本发明提供了式 (I) 的化合物，其中 (B)、Q、J、L 和 Z 如说明书中所定义。
• Triterpene amine derivatives
  申请人：DFH THERAPEUTICS

  公开号：US11236122B2

  公开（公告）日：2022-02-01

  The present invention concerns novel pharmaceutically active triterpene amine derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the triterpene amine compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C-28 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus-1 (HIV-1).

  本发明涉及新型具有药用活性的三萜胺衍生物、含有三萜胺衍生物的药物组合物、其作为药物的用途，以及使用这些化合物制造特定药物。本发明还涉及一种涉及三萜胺化合物给药的治疗方法。具体来说，这些化合物是白桦脂酸的衍生物，在 C-3、C-28 和 C-19 位上有一个或多个取代位，如本文进一步描述的那样。这些新型化合物可用作抗逆转录病毒药物。特别是，这些新型化合物可用于治疗人类免疫缺陷病毒-1（HIV-1）。
• ANTHRANILIC ACID AMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE
  申请人：NOVARTIS AG

  公开号：EP1572686B1

  公开（公告）日：2009-04-15