3a(2),6a(2)-Dihydroxy-4a(2)-[(methylamino)methyl]spiro[isobenzofuran-1(3H),9a(2)-[9H]xanthen]-3-one | 106754-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3a(2),6a(2)-Dihydroxy-4a(2)-[(methylamino)methyl]spiro[isobenzofuran-1(3H),9a(2)-[9H]xanthen]-3-one
• 英文别名: 3',6'-dihydroxy-4'-(methylaminomethyl)spiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 106754-97-6
• 化学式: C₂₂H₁₇NO₅
• 分子量: 375.4
• InChiKey: OADVAXOMMKNSFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  88
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• 4'-aminomethyfluorescein derivatives for use in fluorescence polarization immunoassys
  申请人：ABBOTT LABORATORIES

  公开号：EP0201751A2

  公开（公告）日：1986-11-20

  The present invention is directed to an improved method for the preparation of 4'-aminomethylfluorescein derivatives for use in fluorescence polarization immunoassays. The invention is also directed to a novel class of 4'-N-alkylaminomethylfluorescein derivatives possessing utility as reagents in such assays.

  本发明涉及一种用于荧光偏振免疫测定的 4'-氨甲基荧光素衍生物的改进制备方法。本发明还涉及一类新型的 4'-N-烷基氨甲基荧光素衍生物，该类衍生物在此类检测中可用作试剂。
• Immunoassay reagents and method for determining cyclosporine
  申请人：ABBOTT LABORATORIES

  公开号：EP0473961A2

  公开（公告）日：1992-03-11

  Cyclosporine derivatives useful as detectable tracer compounds for the immunoassay determination of cyclosporine are disclosed. The cyclosporine derivatives comprise a detectable moiety coupled to the amino acid at the first position (MeBmt) in cyclosporine, the second position (Abu) in cyclosporine, the third position (Sar) in cyclosporine, the eighth position (D-Ala) in cyclosporine, or the tenth position (MeLeu) in cyclosporine. A preferred cyclosporine derivative comprises a fluorescent moiety coupled to the hydroxyl group of the amino acid at the first position in cyclosporine, and is especially useful for the fluorescent polarization immunoassay deterimination of cyclosporine. A fluorescent polarization immunoassay method and test kit are also disclosed.

  本发明公开了可用作免疫测定环孢素的可检测示踪化合物的环孢素衍生物。这些环孢素衍生物包括与环孢素第一位（MeBmt）、环孢素第二位（Abu）、环孢素第三位（Sar）、环孢素第八位（D-Ala）或环孢素第十位（MeLeu）氨基酸偶联的可检测分子。一种优选的环孢素衍生物包含一个与环孢素中第一位氨基酸的羟基偶联的荧光分子，特别适用于荧光偏振免疫测定环孢素。还公开了一种荧光偏振免疫测定方法和检测试剂盒。
• US5489668A
  申请人：——

  公开号：US5489668A

  公开（公告）日：1996-02-06
• US5750413A
  申请人：——

  公开号：US5750413A

  公开（公告）日：1998-05-12