diethyl 4-hydroxynaphthalene-1, 3-dicarboxylate | 57593-70-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: diethyl 4-hydroxynaphthalene-1, 3-dicarboxylate
• 英文别名: Diethyl 4-hydroxynaphthalene-1,3-dicarboxylate；diethyl 4-hydroxynaphthalene-1,3-dicarboxylate
• CAS: 57593-70-1
• 化学式: C₁₆H₁₆O₅
• 分子量: 288.3
• InChiKey: VYOOWNQBNMHVLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (E)-2-(ethoxycarbonyl)vinyl 2-chlorobenzoate 在 potassium phosphate 、 copper(l) iodide 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以30%的产率得到diethyl 4-hydroxynaphthalene-1, 3-dicarboxylate
  参考文献：
  名称：

  铜催化烯醇酯合成α-萘酚

  摘要：

  AbstractAn unprecedented synthesis of α‐naphthol derivatives from the reactions of two molecular equivalents of enol esters in the presence of a copper catalyst is described. This protocol is mild and tolerates various functional groups.magnified image

  DOI：

  10.1002/adsc.201300503

文献信息

• Mn(III)-Mediated Facile Access to Polysubstituted α-Naphthols from β-Keto Ester Derivatives and Terminal Alkynes
  作者：Yuzhu Yang、Weidong Pan、Lisheng He、Fei Li、Xiaolan Liu

  DOI：10.1055/s-0039-1690870

  日期：2020.7

  A novel manganese-mediated reaction for the synthesis of polysubstituted α-naphthols has been developed from β-keto esters and terminal alkynes. This system holds the advantages of readily available starting materials and mild conditions. Mechanistic investigations revealed that this reaction proceeds via a tandem radical cyclization process.

  由β-酮酸酯和末端炔烃开发了一种新型的锰介导的合成多取代α-萘酚的反应。该系统具有容易获得的起始原料和温和条件的优点。机理研究表明，该反应是通过串联自由基环化过程进行的。
• Effect of Vitamin D 3 on Cadmium Retention by Laying Hens
  作者：B. Koréneková、A. Jacková、J. Kottferová、P. Siklenka、M. Skalická、M. Korének

  DOI：10.1080/09064700212070

  日期：2002.1
• Copper-Catalyzed Synthesis of α-Naphthols from Enol Esters
  作者：Niranjan Panda、Raghavender Mothkuri、Arpan Pal、Alok R. Paital

  DOI：10.1002/adsc.201300503

  日期：2013.10.11

  AbstractAn unprecedented synthesis of α‐naphthol derivatives from the reactions of two molecular equivalents of enol esters in the presence of a copper catalyst is described. This protocol is mild and tolerates various functional groups.magnified image