diethyl-thiazol-2-yl-amine | 13472-99-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: diethyl-thiazol-2-yl-amine
• 英文别名: Diaethyl-thiazol-2-yl-amin；2-Diaethylamino-thiazol；N,N-diethyl-1,3-thiazol-2-amine
• CAS: 13472-99-6
• 化学式: C₇H₁₂N₂S
• mdl: MFCD06360140
• 分子量: 156.252
• InChiKey: FMPDLFJFQAPPGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  44.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  diethyl-thiazol-2-yl-amine 在 硫酸 、 三氧化硫 作用下， 生成 2-diethylamino-thiazole-5-sulfonic acid
  参考文献：
  名称：

  Synthesis of chlorin e6 amide derivatives

  摘要：

  The reactions of methylpheophorbide a with primary and secondary amines have been investigated as a means for the synthesis of sensitizers used in the photodynamic therapy of tumors.

  DOI：

  10.1070/mc2002v012n02abeh001536
• 作为产物：
  描述：

  2-溴噻唑 、 三乙胺 100.0 ℃ 、800.0 MPa 条件下， 反应 96.0h， 以93%的产率得到diethyl-thiazol-2-yl-amine
  参考文献：
  名称：

  无环叔胺作为芳香族和杂芳香族卤化物取代反应中的亲核体

  摘要：

  甚至被认为对芳族和杂芳族卤化物呈惰性的无环叔胺，如三乙胺，三正丙胺和三正丁胺，也与芳族和杂芳族卤化物进行S N Ar反应，得​​到二烷基氨基衍生物；在单环的胺等的情况下Ñ -甲基吡咯烷和Ñ甲基哌啶，脱烷基化区域选择性被。

  DOI：

  10.1039/c39910000306

文献信息

• Noncatalytic Electrophilic Oxyalkylation of Some Five-Membered Heterocycles with 2-(Trifluoroacetyl)-1,3-azoles
  作者：Pavel Mykhailiuk、Pavel Khodakovskiy、Dmitriy Volochnyuk、Andrey Tolmachev

  DOI：10.1055/s-0029-1218633

  日期：2010.3

  A set of electrophilic 2-(trifluoroacetyl)-1,3-azoles demonstrated­ excellent activity in the C-oxyalkylation of pyrrole, furan, thiophene, 1,3-thiazole, and 1,2-oxazole derivatives. The reaction conditions and the yields of the corresponding trifluoromethyl-substituted alcohols depend strongly on both the electronic and steric nature of the 1,3-azole unit.

  一组电亲性2-(三氟乙酰基)-1,3-唑类化合物在吡咯、呋喃、噻吩、1,3-噻唑和1,2-噁唑衍生物的C-氧烷基化反应中表现出了优异的活性。反应条件和相应三氟甲基取代醇的产率强烈依赖于1,3-唑单元的电子性质和立体性质。
• 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
  申请人：Ennis Michael Dalton

  公开号：US20080176857A1

  公开（公告）日：2008-07-24

  Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本发明揭示了化合物及其药物可接受的盐，其中化合物具有公式I的结构：其中A1、A2、A3、A4、A5、A6、A7、A8、X4、X6、R2、R4、R5和R6如本发明详细描述中所定义。本发明还揭示了相应的药物组合物、治疗方法、合成方法和中间体。
• A straightforward copper-free palladium methodology for the selective alkynylation of a wide variety of S-, O-, and N-based mono- and diheterocyclic bromides and chlorides
  作者：Samer Saleh、Michel Picquet、Philippe Meunier、Jean-Cyrille Hierso

  DOI：10.1016/j.tet.2009.06.009

  日期：2009.8

  High-yield alkynylations are successfully achieved by a simple and widely accessible catalytic system for an unprecedented variety of heterocyclic bromides and chlorides in position -2, -3 or -5: pyridine, quinoline, thiophene, furan, thiazole, benzothiazole, pyrimidine, pyridazine, pyrazine, dioxepin halides are efficiently functionalized in short time reactions. This copper-free methodology employs 1 mol% palladium only, with inexpensive PPh3 and amine base. The ionic liquid solvent allows a straigtforward separation of products and recycling opportunity. Unsuitable substrates and secondary reactions are also reported in order to point out further progress in cross-coupling using ionic liquids. (C) 2009 Elsevier Ltd. All rights reserved.
• ——
  作者：R. V. Smalii

  DOI：10.1023/a:1023372725342

  日期：——

  Amidophosphonium isothiocyanates thiocarbamoylate a series of electron-rich heterocycles and enamines at the nucleophilic carbon atom to form phosphazothiocarbonyl compounds. From the most active heterocycles, bis(phosphazothiocarbonyl) derivatives can be obtained.
• Turkey blackhead control composition
  申请人：AMERICAN CYANAMID CO

  公开号：US02547677A1

  公开（公告）日：1951-04-03