1-(3,4-dihydroisoquinolin-2(1H)-yl)-2-methylprop-2-en-1-one | 10579-63-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-(3,4-dihydroisoquinolin-2(1H)-yl)-2-methylprop-2-en-1-one
• 英文别名: 2-(2-methyl-acryloyl)-1,2,3,4-tetrahydro-isoquinoline；1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-methylprop-2-en-1-one
• CAS: 10579-63-2
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: LSWRJXFXUHBUGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  四氢异喹啉 、 甲基丙烯酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以78.5%的产率得到1-(3,4-dihydroisoquinolin-2(1H)-yl)-2-methylprop-2-en-1-one
  参考文献：
  名称：

  Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer’s disease

  摘要：

  DOI：

  10.1016/j.bioorg.2021.104879

文献信息

• Ink, ink cartridge, ink jet recording device, ink jet ink printed matter, compound, and composition
  申请人：RICOH COMPANY, LTD.

  公开号：US09593248B2

  公开（公告）日：2017-03-14

  Ink contains at least one of a compound represented by the following chemical formula 1, a compound represented by chemical formula 2, a compound represented by chemical formula 3, or a compound represented by chemical formula 4.

  墨水中至少含有以下化学式1代表的化合物、化学式2代表的化合物、化学式3代表的化合物或化学式4代表的化合物之一。
• Palladium catalysed reactions of allenes, carbon monoxide and nucleophiles
  作者：Ronald Grigg、Michael Monteith、Visuvanathar Sridharan、Catherine Terrier

  DOI：10.1016/s0040-4020(98)00115-x

  日期：1998.4

  Hydridopalladium(II) species generated in situ by oxidative addition of Pd(0) to acetic acid or acidic hydroxyl substrates (phenols, oximes) catalyse the termolecular assembly of allenes, CO and amines (primary, secondary) or oxygen nucleophiles to give methacrylamides or methacrylate esters and derivatives thereof in good to excellent yield. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Radical cascade involving a 5-endo-trig cyclization of α-amidoyl radicals
  作者：Hiroyuki Ishibashi、Atsuko Ishita、Osamu Tamura

  DOI：10.1016/s0040-4039(01)02200-6

  日期：2002.1

  Bu3SnH-mediated radical reactions of aryl bromides 4 gave pyrrolo[1,2-b]- and isoindolo[2, I -b]isoquinoline derivatives 11 through a radical cascade process involving a 6-endo-trig cyclization of an aryl radical and a 5-endo-trig cyclization of an alpha-amidoyl radical. (C) 2002 Elsevier Science Ltd. All rights reserved.
• INK, INK CARTRIDGE, INK JET RECORDING DEVICE, INK JET INK PRINTED MATTER, COMPOUND, AND COMPOSITION
  申请人：MORITA Mitsunobu

  公开号：US20140363634A1

  公开（公告）日：2014-12-11

  Ink contains at least one of a compound represented by the following chemical formula 1, a compound represented by chemical formula 2, a compound represented by chemical formula 3, or a compound represented by chemical formula 4.
• INK, INK CARTRIDGE, INK JET RECORDING DEVICE, INK JET INK PRINTED MATTER, COMPOUND, AND COMPOSITION
  申请人：MORITA Mitsunobu

  公开号：US20170137644A1

  公开（公告）日：2017-05-18

  Ink contains at least one of a compound represented by the following chemical formula 1, a compound represented by chemical formula 2, a compound represented by chemical formula 3, or a compound represented by chemical formula 4.