3,3'-(piperazine-1,4-diyl)bis(propan-1-ol) | 28765-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3,3'-(piperazine-1,4-diyl)bis(propan-1-ol)
• 英文别名: N,N'-bis(3-hydroxypropyl)piperazine；3,3'-piperazine-1,4-diyl-bis-propan-1-ol；1,4-bis-(3-hydroxy-propyl)-piperazine；1,4-Bis-(3-hydroxy-propyl)-piperazin；3-[4-(3-hydroxypropyl)-1-piperazinyl]-1-propanol；1,4-bis-(3-hydroxypropyl)piperazine；1,4-Piperazinedipropanol；3-[4-(3-hydroxypropyl)piperazin-1-yl]propan-1-ol
• CAS: 28765-60-8
• 化学式: C₁₀H₂₂N₂O₂
• 分子量: 202.297
• InChiKey: QGTJMDUCAZVEHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,3'-(piperazine-1,4-diyl)bis(propan-1-ol) 在 吡啶 、 palladium 10% on activated carbon 、 氢气 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 50.5h， 生成 piperazine-1,4-diylbis(propane-3,1-diyl) bis(2,3-diacetoxybenzoate)
  参考文献：
  名称：

  Piperazine derivatives as iron chelators: a potential application in neurobiology

  摘要：

  Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects.

  DOI：

  10.1007/s10534-015-9889-x
• 作为产物：
  描述：

  哌嗪-1,4-二丙酸二甲酯 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以72%的产率得到3,3'-(piperazine-1,4-diyl)bis(propan-1-ol)
  参考文献：
  名称：

  Kafka, Stanislav; Cermak, Jan; Novak, Tomas, Collection of Czechoslovak Chemical Communications, 1985, vol. 50, # 5, p. 1201 - 1211

  摘要：

  DOI：

文献信息

• Basic amides of 2,4,5-trichlorophenoxyacetic, 2,4,6-trimethylphenoxyacetic and 4-bromo-3,5-dimethylphenoxyacetic acid and some related compounds; Synthesis and pharmacological screening
  作者：Vladimír Valenta、Jiří Němec、Miroslav Protiva

  DOI：10.1135/cccc19831089

  日期：——

  Reactions of methyl esters II of 2,4,5-trichlorophenoxyacetic (Ia), 2,4,6-trimethylphenoxyacetic (Ib) and 4-bromo-3,5-dimethylphenoxyacetic acid (Ic) with 2-diethylaminoethylamine, 2-morpholinoethylamine, 3-morpholinopropylamine, 1-methylpiperazine, 3-(4-methylpiperazino)propylamine, 3-[4-(2-tolyl)piperazino]propylamine and 1,4-bis(3-aminopropyl)piperazine in boiling ethanol gave the basic amides Va-XIc which were isolated as hydrochlorides. Reactions of the acid chlorides IVa and IVb with 1,4-bis(2-hydroxyethyl)piperazine and 1,4-bis(3-hydroxypropyl)piperazine in dimethylformamide resulted directly in dihydrochlorides of diesters XIIab and XIIIab. The compounds prepared have only weak CNS effects (mostly of the depressant type); they have local anaesthetic, mild hypotensive (some of them adrenolytic), antiarrhythmic and peripheral vasodilating activities.

  甲酯类化合物 II 的反应与 2,4,5-三氯苯氧乙酸 (Ia)、2,4,6-三甲基苯氧乙酸 (Ib) 和 4-溴-3,5-二甲基苯氧乙酸 (Ic) 在沸腾的乙醇中与 2-二乙胺基乙胺、2-吗啉基乙胺、3-吗啉基丙胺、1-甲基哌嗪、3-(4-甲基哌嗪基)丙胺、3-[4-(2-甲苯基)哌嗪]丙胺和 1,4-双(3-氨基丙基)哌嗪的反应产生了基本酰胺 Va-XIc，这些酰胺以盐酸盐的形式分离出来。酸氯化物 IVa 和 IVb 与 1,4-双(2-羟乙基)哌嗪和 1,4-双(3-羟丙基)哌嗪在二甲基甲酰胺中的反应直接产生了双酯的二盐酸盐 XIIab 和 XIIIab。制备的化合物仅具有微弱的中枢神经系统效应（主要是抑制性的）；它们具有局部麻醉、轻度降压（其中一些为肾上腺素受体拮抗剂）、抗心律失常和外周血管扩张活性。
• Novel arylamidine derivative or salt thereof
  申请人：Hayashi Kazyua

  公开号：US20050113424A1

  公开（公告）日：2005-05-26

  An arylamidine derivative represented by a general formula described below or a salt thereof has an excellent antifungal action and high safety, and it is useful as an antifungal agent with good pharmacokinetics and pharmacodynamic properties wherein X represents an unsubstituted or substituted lower alkylene or alkenylene group; G 1 represents an oxygen atom, a sulfur atom, or an imino group; G 2 represents a carbon atom or a nitrogen atom; R a represents at least one group selected from the group consisting of a hydrogen atom, a halogen atom, and unsubstituted or substituted alkyl, cycloalkyl and alkoxy groups; R 1 represents an unprotected or protected or unsubstituted or substituted amidino group; and R 2 represents a substituted amino or substituted cyclic amino group, or the like.

  下面所述的一般式代表的芳基胺衍生物或其盐具有优异的抗真菌作用和高安全性，是一种具有良好药代动力学和药效学特性的抗真菌剂，其中X代表未取代或取代的较低烷基或烯基基团；G1代表氧原子、硫原子或亚胺基；G2代表碳原子或氮原子；Ra代表氢原子、卤原子和未取代或取代的烷基、环烷基和烷氧基等基团中的至少一种；R1代表未保护或保护或未取代或取代的酰胺基团；R2代表取代的氨基或取代的环状氨基等基团。
• Synthesis and characterization of thermoplastic poly(piperazine succinate) metallopolymers coordinated to ruthenium( <scp>III</scp> ) or iron( <scp>III</scp> )
  作者：Jessica K. Schneider、Clarissa A. Ove、Russell K. Pirlo、Justin C. Biffinger

  DOI：10.1002/pol.20220583

  日期：2023.3.15

  molecular weight of the non-metal containing polymers. However, coordination of Fe(III), and to a lesser extent Ru(III), to these polypiperazines accelerated the hydrolysis of the polyester linkage in water over 15 days. Thus, these novel polymers are highly biodegradable with Fe(III) metallopolymers hydrolyzing faster than Ru(III) metallopolymers and poly(propyl piperazine succinate) polymers hydrolyzing

  含金属聚合物代表了材料科学不断扩展的前沿领域。在用于制造金属聚合物的众多生物相容性配体中，含哌嗪的聚合物仍处于早期开发阶段，尽管哌嗪是药物设计和生物工程支架元素中的常见功能基团。我们报告了两种热塑性聚（烷基哌嗪琥珀酸酯）二醇的首次合成和表征（使用 NMR、IR、GPC、紫外-可见光谱和热分析），丙基或己基烷烃链桥接哌嗪。然后用六亚甲基二异氰酸酯对这些聚酯二醇进行扩链，以产生高度无定形的聚酯氨基甲酸酯热塑性聚合物。然后 Ru(III) 或 Fe(III) 成功地与这些聚合物配位，大约 30% 的本体金属聚合物产品的分子量变为不含金属的聚合物的 250 倍。然而，Fe(III) 以及较小程度上的 Ru(III) 与这些聚哌嗪的配位在 15 天内加速了聚酯键在水中的水解。因此，这些新型聚合物是高度可生物降解的，其中 Fe(III) 金属聚合物的水解速度比 Ru(III) 金属聚合物快，聚（丙基哌
• Catalyst composition for polymerization of conjugated diene and process for producing conjugated diene polymer
  申请人：JAPAN SYNTHETIC RUBBER CO., LTD.

  公开号：EP0331400A1

  公开（公告）日：1989-09-06

  A catalyst compositon for polymerizing a conjugated diene which comprises the following (a), (b) and (c) components: a) an organolithium-aluminum compound represented by the formula: LiAlR¹R²R³R⁴ (b) an organobarium-aluminum compound reprsented by the formula: Ba(AlR¹R²R³R⁴)₂ or Ba[AlR¹R²R³(OR⁴)]₂ (c) a lithium alkoxide represented by the formula: LiOR⁵ The conjuaged diene polymer or copolymer obtained by polymerizing a conjuaged diene alone or in combination with other monomer with the above catalyst composition in an inert organic solvent has a high trans-1,4 bond content, a low vinyl bond content and a low cis-1,4 bond content.

  一种用于聚合共轭二烯的催化剂组合物，由以下(a)、(b)和(c)组分组成： a) 由式表示的有机锂铝化合物： LiAlR¹R²R³R⁴ (b) 一种有机钡铝化合物，其化学式为 Ba(AlR¹R²R³R⁴)₂ 或 Ba[AlR¹R²R³(OR⁴)]₂。 (c) 由以下式子表示的烷氧化锂 LiOR⁵ 在惰性有机溶剂中，用上述催化剂组合物单独或与其他单体一起聚合共轭二 烯，得到的共轭二烯聚合物或共聚物具有较高的反式-1,4 键含量、较低的乙烯 键含量和较低的顺式-1,4 键含量。
• Process for producing high trans low vinyl conjugated diene (co) polymer
  申请人：JAPAN SYNTHETIC RUBBER CO., LTD.

  公开号：EP0391692A1

  公开（公告）日：1990-10-10

  A process for producing a high trans low vinyl conjugated diene (co)polymer, comprising polymerizing at least one conjugated diene alone or in combination with at least one alkenyl compound using a catalyst composi­tion comprising (a) a barium compound, (b) an organo­aluminum compound, (c) an organolithium compound and (d) a hydroxyl group-containing organic compound. This process enables the easy production of a high trans low vinyl conjugated diene (co)polymer having a high trans-­1,4 bond content, a low vinyl bond content and a high molecular weight, at a high polymerization activity.

  一种生产高反式低乙烯基共轭二烯（共）聚合物的工艺，包括使用一种催化剂组合物使至少一种共轭二烯单独或与至少一种烯基化合物结合聚合，该催化剂组合物包括(a)一种钡化合物，(b)一种有机铝化合物，(c)一种有机锂化合物和(d)一种含羟基的有机化合物。该工艺可轻松生产出具有高反式-1,4 键含量、低乙烯基键含量和高分子量的高反式低乙烯基共轭二烯（共）聚合物，且聚合活性高。