3-[(3-hydroxypropyl)anilino]-1-propanol | 5279-24-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-[(3-hydroxypropyl)anilino]-1-propanol
• 英文别名: N,N-bis-(3-hydroxy-propyl)-aniline；N,N-Bis-(3-hydroxy-propyl)-anilin；Bis-(γ-oxy-propyl)-anilin；N-Phenyl-N,N-dipropanolamine；3.3'-Dihydroxy-N-phenyl-dipropylamin；N,N-bis(3-hydroxypropyl) aniline；3-[N-(3-hydroxypropyl)anilino]propan-1-ol
• CAS: 5279-24-3
• 化学式: C₁₂H₁₉NO₂
• 分子量: 209.288
• InChiKey: WCXVWPZYKUGXLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  3-[(3-hydroxypropyl)anilino]-1-propanol 在 三氯氧磷 作用下， 生成 N,N-bis-(3-chloro-propyl)-aniline
  参考文献：
  名称：

  420.芳基-2-卤代烷基胺。第二部分

  摘要：

  DOI：

  10.1039/jr9490001972
• 作为产物：
  描述：

  3,3'-(苯基氮二基)二丙酸二乙酯 在 lithium aluminium tetrahydride 作用下， 生成 3-[(3-hydroxypropyl)anilino]-1-propanol
  参考文献：
  名称：

  某些氨基二醇磺酸酯的几种新衍生物的抗癌活性。

  摘要：

  制备了六种新的氨基二醇磺酸酯衍生物，并测试了它们对吉田肉瘤的抑癌活性。所有测试的化合物均对肿瘤细胞显示出强烈的细胞形态学作用，但不能有效延长荷瘤动物的寿命。

  DOI：

  10.1248/cpb.13.1363

文献信息

• Molybdenum dinitrogen complexes facially coordinated by linear tridentate PEP ligands (E = N or P): impact of the central E donor in trans-position to N₂
  作者：Svea Hinrichsen、Ann-Christin Schnoor、Katharina Grund、Benedikt Flöser、Alexander Schlimm、Christian Näther、Jan Krahmer、Felix Tuczek

  DOI：10.1039/c6dt02316a

  日期：——

  The syntheses of molybdenum dinitrogen complexes supported by the tridentate PEP ligands (E = N, P) prPP(Ph)P = (Ph2PCH2CH2CH2)2P(Ph), prPPHP = (Ph2PCH2CH2CH2)2PH, PN(Ph)P = (Ph2PCH2CH2)2N(Ph) and prPN(Ph)P = (Ph2PCH2CH2CH2)2N(Ph) are reported. Together with the coligand dmpm = (CH3)2PCH2P(CH3)2 dinitrogen complexes of the type [Mo(N2)(PEP)(dmpm)] are formed. The new systems are characterized by IR

  三齿PEP配体（E = N，P）prPP（Ph）P =（Ph 2 PCH 2 CH 2 CH 2）2 P（Ph），prPPHP =（Ph 2 PCH 2 CH 2报告了CH 2）2 PH，PN（Ph）P =（Ph 2 PCH 2 CH 2）2 N（Ph）和prPN（Ph）P =（Ph 2 PCH 2 CH 2 CH 2）2 N（Ph）。连同大肠菌dmpm =（CH 3）2 PCH形成类型为[Mo（N 2）（PEP）（dmpm）]的2 P（CH 3） 2二氮配合物。新系统的特征在于IR和NMR光谱，并与文献中已知的复合物[Mo（N 2）（dpepp）（dmpm）]（ 1）（dpepp = PhP（CH 2 CH 2 PPh 2） 2）进行了比较。关于相应N 2的稳定性，研究了用N取代dpepp的中心P-供体和用C 3键取代其C 2以及通过EH功能交换EPh的后果。-复杂。重要的是，当用反式胺供体代替反式膦时，N
• Electronically tuned 1,3,5-triarylpyrazolines as Cu(i)-selectivefluorescent probes
  作者：Manjusha Verma、Aneese F. Chaudhry、M. Thomas Morgan、Christoph J. Fahrni

  DOI：10.1039/b918311f

  日期：——

  We have prepared and characterized a Cu(I)-responsive fluorescent probe, constructed using a large tetradentate, 16-membered thiazacrown ligand ([16]aneNS3) and 1,3,5-triaryl-substituted pyrazoline fluorophores. The fluorescence contrast ratio upon analyte binding, which is mainly governed by changes of the photoinduced electron transfer (PET) driving force between the ligand and fluorophore, was systematically optimized by increasing the electron withdrawing character of the 1-aryl-ring, yielding a maximum 50-fold fluorescence enhancement upon saturation with Cu(I) in methanol and a greater than 300-fold enhancement upon protonation with trifluoroacetic acid. The observed fluorescence increase was selective towards Cu(I) over a broad range of mono- and divalent transition metal cations. Previously established Hammett LFERs proved to be a valuable tool to predict two of the PET key parameters, the acceptor potential (E(A/A−) and the excited state energy ΔE00, and thus to identify a set of pyrazolines that would best match the thermodynamic requirements imposed by the donor potential E(D+/D) of the thiazacrown receptor. The described approach should be applicable for rationally designing high-contrast pyrazoline-based PET probes selective towards other metal cations.

  我们制备并表征了一种响应于Cu(I)的荧光探针，该探针使用了一个大型四齿、16元环硫氮冠醚配体（[16]aneNS3）和1,3,5-三芳基取代的吡唑啉荧光团。分析物结合后的荧光对比度，主要由配体与荧光团之间光诱导电子转移（PET）驱动力的变化决定，通过增加1-芳基环的电子吸引特性进行了系统优化，在甲醇中与Cu(I)饱和时可实现最大50倍的荧光增强，而在三氟醋酸质子化后可实现超过300倍的增强。所观察到的荧光增加对Cu(I)具有选择性，且在广泛的单价和二价过渡金属阳离子中表现良好。先前建立的Hammett线性自由能关系（LFER）被证明是预测PET关键参数（受体电位E(A/A−)和激发态能量ΔE00）的有价值工具，从而识别出一组最符合硫氮冠 receptor 的给体电位E(D+/D)热力学要求的吡唑啉化合物。所描述的方法应适用于合理设计针对其他金属阳离子的高对比度吡唑啉基PET探针。
• Herbicidal compositions
  申请人：Velsicol Chemical Corporation

  公开号：US03941580A1

  公开（公告）日：1976-03-02

  This invention discloses compounds of the formula ##SPC1## Wherein X is alkyl; t is an integer from 0 to 3; Y is a straight or branched alkylene chain of from 2 to 3 carbon atoms. The compounds of the above description are useful as herbicides which resist leaching in the soil.

  这项发明揭示了以下化合物的结构公式：##SPC1## 其中X是烷基；t是0到3之间的整数；Y是由2到3个碳原子组成的直链或支链烷基链。上述描述的化合物可用作抗土壤淋洗的除草剂。
• Ink composition
  申请人：Zeneca Limited

  公开号：US06099625A1

  公开（公告）日：2000-08-08

  Compounds and ink compositions. An ink composition comprising a compound of Formula (1) and salts thereof: ##STR1## wherein Ch represents an arrangement of atoms which causes the compound to absorb electromagnetic radiation; R.sup.a and R.sup.b each independently is a spacer group; Y is an interactive functional group; w and x each independently is 0 or an integer equal to or greater than 1; and m and n each independently is an integer equal to or greater than 1, provided that w and x are not both equal to zero and when one of w or x is 0 at least one of m and n is equal to or greater than 2. For use in ink jet printing and electrophotography.

  化合物和油墨组成物。一种油墨组成物，包括式（1）的化合物及其盐：##STR1## 其中Ch代表原子排列，使得该化合物吸收电磁辐射；R.sup.a和R.sup.b各自独立地是间隔基团；Y是交互作用的功能基团；w和x各自独立地为0或大于等于1的整数；m和n各自独立地是大于等于1的整数，但前提是w和x不都等于零，当w或x中的一个为零时，至少有一个m或n等于2或更大。用于喷墨印刷和电子照相。
• Polyestercarbonate/polyetherimide blends
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0158733A1

  公开（公告）日：1985-10-23

  The invention concerns blends of polyestercarbonates and polyetherimides. More particularly, the invention is concerned with such blends having enhanced physical and/- or chemical properties. The polyetherimide-polyestercarbonate blends are suitable for the manufacture of fibers, films, sheets, laminates and articles of manufacture including reinforced articles made by conventional manufacturing techniques.

  本发明涉及聚酯碳酸酯和聚醚酰亚胺的混合物。更具体地说，本发明涉及具有更强物理和/或化学特性的此类混合物。聚醚酰亚胺-聚碳酸酯混合物适用于制造纤维、薄膜、板材、层压板和制品，包括用传统制造技术制造的增强制品。