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5-Methyl-2-triethylsilyl-furan-4-ylmethanol | 145839-24-3

中文名称
——
中文别名
——
英文名称
5-Methyl-2-triethylsilyl-furan-4-ylmethanol
英文别名
5-methyl-2-triethylsilyl-4-furanmethanol;5-Methyl-2-triethylsilyl-4-furylmethanol;(2-methyl-5-triethylsilylfuran-3-yl)methanol
5-Methyl-2-triethylsilyl-furan-4-ylmethanol化学式
CAS
145839-24-3
化学式
C12H22O2Si
mdl
——
分子量
226.391
InChiKey
NFPKPCPJGNNXJU-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    224.4±10.0 °C(predicted)
  • 密度:
    0.95±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    2.8
  • 重原子数:
    15
  • 可旋转键数:
    5
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.67
  • 拓扑面积:
    33.4
  • 氢给体数:
    1
  • 氢受体数:
    2

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    参考文献:
    名称:
    2-trialkylsilyl-3-furaldehydes
    摘要:
    抗炎4-取代的2-呋喃酮是由具有以下公式的中间体制备的:##STR1## 其中R.sub.1、R.sub.2和R.sub.3分别是1至6个碳原子的n-或支链烷基。这些化合物可用作中间体,以生产具有抗炎作用的4-取代的2-呋喃酮。
    公开号:
    US05322953A1
  • 作为产物:
    描述:
    乙醚 、 2-methyl-5-triethylsilyl-3-furaldehyde 在 LiAlH4 作用下, 以 四氢呋喃正己烷 为溶剂, 生成 5-Methyl-2-triethylsilyl-furan-4-ylmethanol
    参考文献:
    名称:
    Pharmaceutical compositions and method for administering 3 and
    摘要:
    3和4-取代的2(5H)-呋喃酮化合物影响哺乳动物,包括人类的骨生成和骨吸收之间的平衡。这些活性化合物以有效剂量(每公斤体重范围在0.05至100毫克之间)被用于哺乳动物,包括人类,旨在影响骨生成和骨吸收之间的平衡,特别用于治疗骨质疏松症。
    公开号:
    US05268387A1
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文献信息

  • Intermediates and processes for preparing 4-substituted 2-5(H)-furanones
    申请人:Allergan, Inc.
    公开号:US05082954A1
    公开(公告)日:1992-01-21
    Anti-inflammatory 4-substituted 2-furanones are made from intermediates having the formulas: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons; X is H, OH, NH.sub.2, I or Br; R.sub.4 is H, alkyl of 1-20 carbons, phenyl[C.sub.1 -C.sub.20 alkyl], naphthyl[C.sub.1 -C.sub.20 alkyl], CH.sub.2 OH, CH.sub.2 NH.sub.2, CH.sub.2 CH.sub.2 OH, CH.sub.2 --CHO, CH.sub.2 --COOH or CH.sub.2 --COOR.sub.5, and R.sub.5 is alkyl of 1 to 6 carbons, with the proviso that when X is hydrogen then R.sub.4 is selected from the group consisting of CH.sub.2 OH, CH.sub.2 NH.sub.2, CH.sub.2 CH.sub.2 OH, CH.sub.2 --CHO, or CH.sub.2 --COOR.sub.5 ; ##STR2## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl or 1 to 6 carbons, and R.sub.5 is alkyl or 1 to 6 carbons; ##STR3## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons, and R.sub.6 is phenyl, or alkyl of 1 to 6 carbons, and ##STR4## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons.
    抗炎症的4-取代的2-呋喃酮是由具有以下结构的中间体制备的:##STR1## 其中R.sub.1,R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基,或者1到6个碳原子的支链烷基;X是H,OH,NH.sub.2,I或Br;R.sub.4是H,1-20个碳原子的烷基,苯基[C.sub.1-C.sub.20烷基],萘基[C.sub.1-C.sub.20烷基],CH.sub.2 OH,CH.sub.2 NH.sub.2,CH.sub.2 CH.sub.2 OH,CH.sub.2 --CHO,CH.sub.2 --COOH或CH.sub.2 --COOR.sub.5,而R.sub.5是1到6个碳原子的烷基,但当X为氢时,R.sub.4从CH.sub.2 OH,CH.sub.2 NH.sub.2,CH.sub.2 CH.sub.2 OH,CH.sub.2 --CHO或CH.sub.2 --COOR.sub.5的组中选择;##STR2## 其中R.sub.1,R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基,或者1到6个碳原子的支链烷基,而R.sub.5是1到6个碳原子的烷基;##STR3## 其中R.sub.1,R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基,或者1到6个碳原子的支链烷基,而R.sub.6是苯基,或者1到6个碳原子的烷基,以及##STR4## 其中R.sub.1,R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基,或者1到6个碳原子的支链烷基。
  • Intermediates for preparing 4-substituted 2-5(H)-furanones as
    申请人:Allergan, Inc.
    公开号:US05171863A1
    公开(公告)日:1992-12-15
    Anti-inflammatory 4-substituted 2-furanones are made from intermediates having the formulas: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons; X is H, OH, NH.sub.2, I or Br; R.sub.4 is H, alkyl of 1-20 carbons, phenyl[C.sub.1 -C.sub.20 alkyl], naphthyl[C.sub.1 -C.sub.20 alkyl], CH.sub.2 OH, CH.sub.2 NH.sub.2, CH.sub.2 CH.sub.2 OH, CH.sub.2 --CHO, CH.sub.2 --COOH or CH.sub.2 --COOR.sub.5, and R.sub.5 is alkyl of 1 to 6 carbons, with the proviso that when X is hydrogen then R.sub.4 is selected from the group consisting of CH.sub.2 OH, CH.sub.2 NH.sub.2, CH.sub.2 CH.sub.2 OH, CH.sub.2 --CHO, or CH.sub.2 --COOR.sub.5 ; ##STR2## in which R.sub.1, R.sub.2 R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons, and R.sub.5 is alkyl of 1 to 6 carbons; ##STR3## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons, and R.sub.6 is phenyl, or alkyl of 1 to 6 carbons, and ##STR4## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons.
    抗炎4-取代2-呋喃酮是由中间体制备而成,其化学式如下:##STR1## 其中,R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基,或者是1到6个碳的支链烷基;X是H、OH、NH.sub.2、I或Br;R.sub.4是H、1-20个碳的烷基、苯基[C.sub.1-C.sub.20烷基]、萘基[C.sub.1-C.sub.20烷基]、CH.sub.2 OH、CH.sub.2 NH.sub.2、CH.sub.2 CH.sub.2 OH、CH.sub.2 --CHO、CH.sub.2 --COOH或CH.sub.2 --COOR.sub.5,其中R.sub.5是1到6个碳的烷基,但是当X是氢时,R.sub.4的选择范围包括CH.sub.2 OH、CH.sub.2 NH.sub.2、CH.sub.2 CH.sub.2 OH、CH.sub.2 --CHO或CH.sub.2 --COOR.sub.5;##STR2## 其中,R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基,或者是1到6个碳的支链烷基,而R.sub.5是1到6个碳的烷基;##STR3## 其中,R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基,或者是1到6个碳的支链烷基,而R.sub.6是苯基或1到6个碳的烷基;##STR4## 其中,R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基,或者是1到6个碳的支链烷基。
  • 2- and 5-alkyl and phenyl substituted 4-(1-hydroxy, 1-acyloxy or
    申请人:Allergan, Inc.
    公开号:US05183906A1
    公开(公告)日:1993-02-02
    Novel anti-inflammatory furanone compounds have the following formula ##STR1## where R.sub.1 independently is H, phenyl, C.sub.1 -C.sub.6 alkyl substituted phenyl, halogen substituted phenyl, or alkyl of 1 to 6 carbons and n is an integer having the values of 1 or 2, and where when n is 1 the R.sub.1 group is attached either to the 3 or to the 5 position of the 2-furanone, when n is 2 then R.sub.1 is attached to both the 3 and 5 positions, with the proviso that when n is 1 then R.sub.1 is not H; Y.sub.1 is H, alkyl of 1 to 20 carbons, phenyl C.sub.1 -C.sub.20 alkyl, C.sub.1 -C.sub.20 alkenyl containing one or more olephinic bonds, PO(OH).sub.2, PO(OH)OR.sub.2, PO(OH)R.sub.2, PO(OR.sub.2).sub.2, where R.sub.2 is independently alkyl of 1 to 20 carbons, phenyl, or halogen substituted phenyl or C.sub.1 -C.sub.6 alkyl substituted phenyl, further Y.sub.1 is CO--R.sub.3, CO--OR.sub.3, CONHR.sub.3, SO.sub.2 R.sub.3, SO.sub.2 NHR.sub.3, (CH.sub.2).sub.p --O--R.sub.3, or (CH.sub.2).sub.p --O--(CH.sub.2).sub.m --O--R.sub.3, where p, and m, are integers and are independently 1 to 20 and R.sub.3 is H, C.sub.1 -C.sub.20 alkyl, C.sub.1 -C.sub.20 alkenyl containing one or more olephinic bonds, phenyl, halogen substituted phenyl or C.sub.1 -C.sub.6 alkyl substituted phenyl, with the proviso that when Y.sub.1 is CO--R.sub.3, CO--OR.sub.3, and CONHR.sub.3 then R.sub.3 is not hydrogen; Y.sub.2 is H, an alkyl group of 1 to 25 carbons, phenyl, naphthyl, phenyl (C.sub.1 -C.sub.20)alkyl-, naphthyl (C.sub.1 -C.sub.20)alkyl-, halogen substituted phenyl, C.sub.1 -C.sub.6 alkyl substituted phenyl, halogen substituted naphthyl, C.sub.1 -C.sub.6 substituted naphthyl; Y.sub.3 is H, alkyl of 1 to 20 carbons, CO--R.sub.4, CO--O--R.sub.4, CO--NH--R.sub.4, PO(OR.sub.4).sub.2 or PO(OR.sub.4)R.sub.4, where R.sub.4 independently is H, alkyl of 1 to 20 carbons, phenyl, or halogen substituted phenyl or C.sub.1 -C.sub.6 alkyl substituted phenyl.
    新型抗炎症呋喃酮类化合物的化学式如下:##STR1## 其中,R.sub.1独立地为H,苯基,C.sub.1-C.sub.6烷基取代的苯基,卤素取代的苯基,或1至6个碳的烷基,n为整数,取值为1或2,当n为1时,R.sub.1基团连接到2-呋喃酮的3或5位,当n为2时,R.sub.1连接到3和5位,但n为1时,R.sub.1不为H;Y.sub.1为H,1至20个碳的烷基,苯基C.sub.1-C.sub.20烷基,C.sub.1-C.sub.20烯基,含有一个或多个烯丙基键的PO(OH).sub.2,PO(OH)OR.sub.2,PO(OH)R.sub.2,PO(OR.sub.2).sub.2,其中R.sub.2独立地为1至20个碳的烷基,苯基,或卤素取代的苯基或C.sub.1-C.sub.6烷基取代的苯基,此外,当Y.sub.1为CO--R.sub.3,CO--OR.sub.3和CONHR.sub.3时,R.sub.3不为氢;Y.sub.2为H,1至25个碳的烷基,苯基,萘基,苯基(C.sub.1-C.sub.20)烷基,萘基(C.sub.1-C.sub.20)烷基,卤素取代的苯基,C.sub.1-C.sub.6烷基取代的苯基,卤素取代的萘基,C.sub.1-C.sub.6取代的萘基;Y.sub.3为H,1至20个碳的烷基,CO--R.sub.4,CO--O--R.sub.4,CO--NH--R.sub.4,PO(OR.sub.4).sub.2或PO(OR.sub.4)R.sub.4,其中R.sub.4独立地为H,1至20个碳的烷基,苯基,或卤素取代的苯基或C.sub.1-C.sub.6烷基取代的苯基。
  • Pharmaceutical compositions and method for administering 3 and
    申请人:Allergan, Inc.
    公开号:US05268387A1
    公开(公告)日:1993-12-07
    3 and 4-substituted 2(5H)-furanone compounds influence the balance between bone production and bone resorption in mammals, including humans. The active compounds are administered to mammals, including humans, in an effective dose which ranges between 0.05 to 100 mg per kilogram, body weight, per day, for the purpose of influencing the balance between bone production and bone resorption, and particularly for treating osteoporosis.
    3和4-取代的2(5H)-呋喃酮化合物影响哺乳动物,包括人类的骨生成和骨吸收之间的平衡。这些活性化合物以有效剂量(每公斤体重范围在0.05至100毫克之间)被用于哺乳动物,包括人类,旨在影响骨生成和骨吸收之间的平衡,特别用于治疗骨质疏松症。
  • 2-trialkylsilyl-3-furaldehydes
    申请人:Allergan, Inc.
    公开号:US05322953A1
    公开(公告)日:1994-06-21
    Anti-inflammatory 4-substituted 2-furanones are made from intermediates having the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 independently are n-or branched chain alkyl of 1 to 6 carbons. These compounds can be used as intermediates to produce 4-substituted 2-furanones which are anti-inflammatory agents.
    抗炎4-取代的2-呋喃酮是由具有以下公式的中间体制备的:##STR1## 其中R.sub.1、R.sub.2和R.sub.3分别是1至6个碳原子的n-或支链烷基。这些化合物可用作中间体,以生产具有抗炎作用的4-取代的2-呋喃酮。
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