2-(5-cyano-3,3-dimethyl-8-morpholino-2,4-dihydro-1H-pyrano[3,4-c]pyridin-6-sulfanyl)acetamide | 932988-85-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃吡啶类
• 英文名称: 2-(5-cyano-3,3-dimethyl-8-morpholino-2,4-dihydro-1H-pyrano[3,4-c]pyridin-6-sulfanyl)acetamide
• 英文别名: 2-{[5-Cyano-3,3-dimethyl-8-(morpholin-4-YL)-1H,3H,4H-pyrano[3,4-C]pyridin-6-YL]sulfanyl}acetamide；2-[(5-cyano-3,3-dimethyl-8-morpholin-4-yl-1,4-dihydropyrano[3,4-c]pyridin-6-yl)sulfanyl]acetamide
• CAS: 932988-85-7
• 化学式: C₁₇H₂₂N₄O₃S
• mdl: MFCD14826325
• 分子量: 362.453
• InChiKey: XZVITLRWSZOCNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(5-cyano-3,3-dimethyl-8-morpholino-2,4-dihydro-1H-pyrano[3,4-c]pyridin-6-sulfanyl)acetamide 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以80%的产率得到1-amino-8,8-dimethyl-5-morpholin-4-yl-8,9-dihydro-6H-pyrano[4,3-d]thieno[2,3-b]pyridine-2-carboxamide
  参考文献：
  名称：

  Synthesis of 2,3-disubstituted derivatives of pyrano-, thiopyrano-, and benzoannelated pyrido[2,3-b]thieno[3,2-d]pyrimidines

  摘要：

  A new methods have been developed for the synthesis of condensed pyrido[2,3-b]thieno[3,2-d]pyrimidines based on cyclic derivatives of 4-cyanopyridine-3-thiones. The presence of two different reactive functional groups NH2 and CONH gives the possibility of carrying out different conversions of thieno[2,3-b]pyridines.

  DOI：

  10.1007/s10593-008-0145-y
• 作为产物：
  描述：

  6-mercapto-3,3-dimethyl-8-morpholin-4-yl-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile 、 氯乙酰胺 在 sodium carbonate 作用下， 以 水 为溶剂， 反应 1.0h， 以74%的产率得到2-(5-cyano-3,3-dimethyl-8-morpholino-2,4-dihydro-1H-pyrano[3,4-c]pyridin-6-sulfanyl)acetamide
  参考文献：
  名称：

  Synthesis of 2,3-disubstituted derivatives of pyrano-, thiopyrano-, and benzoannelated pyrido[2,3-b]thieno[3,2-d]pyrimidines

  摘要：

  A new methods have been developed for the synthesis of condensed pyrido[2,3-b]thieno[3,2-d]pyrimidines based on cyclic derivatives of 4-cyanopyridine-3-thiones. The presence of two different reactive functional groups NH2 and CONH gives the possibility of carrying out different conversions of thieno[2,3-b]pyridines.

  DOI：

  10.1007/s10593-008-0145-y

文献信息

• Synthesis of 2,3-disubstituted derivatives of pyrano-, thiopyrano-, and benzoannelated pyrido[2,3-b]thieno[3,2-d]pyrimidines
  作者：E. G. Paronikian、Sh. F. Akopian、A. S. Noravian

  DOI：10.1007/s10593-008-0145-y

  日期：2008.8

  A new methods have been developed for the synthesis of condensed pyrido[2,3-b]thieno[3,2-d]pyrimidines based on cyclic derivatives of 4-cyanopyridine-3-thiones. The presence of two different reactive functional groups NH2 and CONH gives the possibility of carrying out different conversions of thieno[2,3-b]pyridines.