1-Isopropyl-cyclohexylamin | 35683-22-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Isopropyl-cyclohexylamin
• 英文别名: 1-(Propan-2-yl)cyclohexan-1-amine；1-propan-2-ylcyclohexan-1-amine
• CAS: 35683-22-8
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: AGBSJYSCEPQEJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-异丙基-环己醇 生成 1-Isopropyl-cyclohexylamin
  参考文献：
  名称：

  Drefahl,G. et al., Journal fur praktische Chemie (Leipzig 1954), 1964, vol. 23, p. 136 - 142

  摘要：

  DOI：

文献信息

• [EN] UREA DERIVATIVES OF AMPHOTERICIN B DERIVED FROM SECONDARY AMINES<br/>[FR] DÉRIVÉS D'URÉE DE L'AMPHOTÉRICINE B DÉRIVÉE D'AMINES SECONDAIRES
  申请人：UNIV ILLINOIS

  公开号：WO2016112243A1

  公开（公告）日：2016-07-14

  Provided are certain urea derivatives of amphotericin B (AmB) having improved therapeutic index compared to AmB. The compounds of the invention are less toxic than AmB and are useful to treat fungal infections. In certain embodiments the urea derivative of AmB is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof: wherein, independently for each occurrence: R represents methyl, ethyl, propyl, or isopropyl; R' represents methyl, ethyl, propyl, or isopropyl; or R and R', taken together with the nitrogen atom to which they are attached, represent a radical of a cyclic secondary amine. Also provided are methods for making the urea derivatives of AmB.

  提供了与两性霉素B（AmB）相比具有改善的治疗指数的某些尿素衍生物。本发明的化合物比AmB毒性更小，并且可用于治疗真菌感染。在某些实施例中，AmB的尿素衍生物是由以下式（I）表示的化合物或其药用可接受的盐：其中，对于每次出现独立地：R代表甲基、乙基、丙基或异丙基；R'代表甲基、乙基、丙基或异丙基；或R和R'与它们连接的氮原子一起表示环状二级胺的基团。还提供了制备AmB的尿素衍生物的方法。
• HMG-CoA reductase inhibitors
  申请人：Stein Philip D.

  公开号：US20070249583A1

  公开（公告）日：2007-10-25

  Compounds are provided of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia and dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis wherein A is chosen from B is chosen from wherein the variables R 1 to R 7 , m, n, are as defined herein. A method for treating the above diseases employing the above compounds is also provided.

  提供以下结构的化合物是HMG CoA还原酶抑制剂，因此在抑制胆固醇生物合成、调节血清脂质，例如降低LDL胆固醇和/或增加HDL胆固醇，以及治疗高脂蛋白血症和血脂异常、高胆固醇血症、高甘油三酯血症和动脉粥样硬化方面具有活性。 其中A选择自 B选择自 其中变量R1至R7，m，n， 如本文所定义。 还提供了一种利用上述化合物治疗上述疾病的方法。
• [EN] METHODS FOR EXTRACTION, PROCESSING, AND PURIFICATION OF A SELECTED FAMILY OF TARGET COMPOUNDS FROM CANNABIS<br/>[FR] PROCÉDÉS D'EXTRACTION, DE TRAITEMENT ET DE PURIFICATION D'UNE FAMILLE SÉLECTIONNÉE DE COMPOSÉS CIBLES À PARTIR DE CANNABIS
  申请人：NECTAR HEALTH SCIENCES INC

  公开号：WO2020248077A1

  公开（公告）日：2020-12-17

  Disclosed are methods for separating, recovering, and purifying tetrahydrocannabinolic acid (THCA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in a selected C5-C7 hydrocarbon solvent, adding thereto a selected amine to thereby precipitate a THCA-amine salt therefrom, dissolving the recovered THCA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallize a purified THCA-amine salt therefrom. The recrystallized THCA-amine salt may be decarboxylated to form a mixture of Δ9-tetrahydrocannabinol (Δ9-THC) and amine. The Δ9-THC amine mixture may be acidified to separate the amine from Δ9-THC. The recovered Δ9-THC may be concentrated to produce a highly purified Δ9-THC. Also disclosed are THCA-amine salts produced with amines selected from groups of diamines, amino alcohols, and tertiary amines.

  揭示了一种从含有大麻酸（THCA）盐的有机溶剂溶液中分离、回收和纯化THCA盐的方法。该方法包括将大麻素混合物溶解在选择的C5-C7烃类溶剂中，加入选择的胺类物质以沉淀出THCA-胺盐，将回收的THCA-胺盐溶解在选择的溶剂中，然后加入选择的抗溶剂以再结晶出纯化的THCA-胺盐。再结晶的THCA-胺盐可以脱羧生成Δ9-四氢大麻酚（Δ9-THC）和胺的混合物。Δ9-THC胺混合物可以酸化以将胺与Δ9-THC分离。回收的Δ9-THC可以浓缩以生产高度纯化的Δ9-THC。还披露了使用二胺、氨基醇和三级胺等胺类物质生产的THCA-胺盐。
• PROCESS FOR PREPARING SECONDARY AMINES IN THE LIQUID PHASE
  申请人：Wigbers Christof Wilhelm

  公开号：US20130178656A1

  公开（公告）日：2013-07-11

  The present application relates to a process for preparing secondary amines by aminating excess primary or secondary alcohols with primary amines in the liquid phase in the presence of copper-comprising catalysts.

  本申请涉及一种通过在液相中在含铜催化剂存在下，用一次胺对多余的一次或二次醇进行胺化，制备二次胺的方法。
• [EN] METHOD OF PREPARATION OF (4 - {4 -ACETYLAMINO- 2 - [3- ( 2 - ISOPROPYL - THIAZOL - 4 - YLMETHYL) - 3 -METHYL - UREIDO] - BUTYRYL AMINO} -1 -BENZYL- 5 -PHENYL- PENTYL) -CARBAMIC ACID THIAZOL - 5 - YLMETHYL ESTER<br/>[FR] PROCÉDÉ DE PRÉPARATION DE L'ESTER THIAZOL-5-YLMÉTHYL DE L'ACIDE (4-{4-ACÉTYLAMINO-2-[3-(2-ISOPROPYL-THIAZOL-4-YLMÉTHYL)-3-MÉTHYL-URÉIDO]-BUTYRYL AMINO}-1-BENZYL-5-PHÉNYL-PENTYL) CARBAMIQUE
  申请人：GILEAD SCIENCES INC

  公开号：WO2012045007A1

  公开（公告）日：2012-04-05

  The invention provides methods and intermediates that are useful for preparing a compound of formula I: and salts thereof.

  这项发明提供了用于制备化合物I的方法和中间体，以及其盐。