5(6)-carboxyfluorescein | 76808-34-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5(6)-carboxyfluorescein
• 英文别名: carboxy fluorescein；3',6'-Dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4-carboxylic acid
• CAS: 76808-34-9
• 化学式: C₂₁H₁₂O₇
• 分子量: 376.322
• InChiKey: UXFKDRQTPIYUML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5(6)-carboxyfluorescein 、 (1R,2S,5R)-Menthyl chloroformate 在 N,N-二异丙基乙胺 作用下， 以 formamide 为溶剂， 以66%的产率得到(-)-menthyl carbamate
  参考文献：
  名称：

  Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis

  摘要：

  本发明揭示了基本纯的二苯乙烯化合物的异构体。各种分子生物学应用利用异构体二苯乙烯荧光染料作为标记物，标记基质如核苷酸，核苷，多核苷酸，多肽和碳水化合物。方法包括DNA测序，DNA片段分析，PCR，SNP分析，寡核苷酸连接，扩增，微型测序和引物延伸。

  公开号：

  US06448407B1

文献信息

• [EN] COMPOUNDS FOR USE AS PROTON CHANNELS AND METHODS THEREOF<br/>[FR] COMPOSÉS DESTINÉS À ÊTRE UTILISÉS EN TANT QUE CANAUX DE PROTONS ET PROCÉDÉS ASSOCIÉS
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2020159441A1

  公开（公告）日：2020-08-06

  The present disclosure relates generally to compounds or a salt, solvate, stereoisomer and prodrug thereof for forming synthetic membrane channels. The present disclosure also relates to methods of synthesizing the compounds, methods of forming the synthetic membrane channels and methods of use thereof. In particular, the synthetic membrane channels are synthetic proton channels in a lipid membrane.

  本公开涉及一般用于形成合成膜通道的化合物或其盐、溶剂化合物、立体异构体和前药。本公开还涉及合成该化合物的方法、形成合成膜通道的方法以及使用方法。具体而言，合成膜通道是位于脂质膜中的合成质子通道。
• Compositions for Targeted Delivery of siRNA
  申请人：Rozema David B.

  公开号：US20110207799A1

  公开（公告）日：2011-08-25

  The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

  本发明涉及用于靶向递送RNA干扰（RNAi）多核苷酸至体内肝细胞的组合物。靶向RNAi多核苷酸与共靶向递送聚合物一起给予。递送聚合物提供膜穿透功能，用于将RNAi多核苷酸从细胞外运送到细胞内。可逆修饰为递送聚合物提供生理响应性。
• GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR siRNA
  申请人：Hadwiger Philipp

  公开号：US20120157509A1

  公开（公告）日：2012-06-21

  The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.

  本发明涉及用于靶向递送RNA干扰（RNAi）多核苷酸至体内细胞的组合物。与单独的靶向配体相比，药代动力学调节剂改善了体内靶向。靶向配体-药代动力学调节剂靶向基团靶向的RNAi多核苷酸可以单独或与共靶向递送聚合物一起在体内给予。
• Phenanthrene derivatives for use as medicaments
  申请人：Valentia Biopharma

  公开号：EP2742974A1

  公开（公告）日：2014-06-18

  Phenanthrene derivatives of formula I for use as medicaments. The present invention refers to phenanthrene derivatives for use as medicaments, mainly in the prevention and/or treatment of DM1, HDL2, SCA8, DM2, SCA3, FXTAS, FTD/ALS, and SCA31. In a preferred embodiment, phenanthrene derivatives of the invention are also used as antimyotonic agents.

  公式I的菲南三烯衍生物用作药物。本发明涉及用作药物的菲南三烯衍生物，主要用于预防和/或治疗DM1、HDL2、SCA8、DM2、SCA3、FXTAS、FTD/ALS和SCA31。在一个优选实施例中，本发明的菲南三烯衍生物也用作抗肌肉张力剂。
• [EN] BONE ACTIVE NITROGEN-CONTAINING BISPHOSPHONATES WITH A NEAR INFRARED FLUORESCENT LABEL<br/>[FR] BISPHOSPHONATES CONTENANT DE L'AZOTE ACTIFS DANS L'OS AYANT UN MARQUEUR FLUORESCENT DANS LE PROCHE INFRAROUGE
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2017053486A1

  公开（公告）日：2017-03-30

  A compound of Formula (I) has the structure: wherein G is a straight, branched or cyclic alkyl group having 2 to 50 carbon atoms or an ether group, and R is a fluorescent dye. In some embodiments, G is selected from the group consisting of -(CH2)n- and -(CH2OCH2)m-, wherein n is an integer from 2 to 18, m is an integer from 2 to 18.

  式（I）的化合物具有以下结构：其中G是具有2到50个碳原子的直链、支链或环烷基基团或醚基团，R是荧光染料。在某些实施例中，G从组中选择，该组由-(CH2)n-和-(CH2OCH2)m-组成，其中n是从2到18的整数，m是从2到18的整数。