4-phenylnaphthalic anhydride | 56252-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-phenylnaphthalic anhydride
• 英文别名: 4-phenyl-naphthalene-1,8-dicarboxylic acid anhydride；4-Phenylnaphthalic-anhydrid；8-Phenyl-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaene-2,4-dione
• CAS: 56252-15-4
• 化学式: C₁₈H₁₀O₃
• 分子量: 274.276
• InChiKey: RRFUEKPGANABHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-phenylnaphthalic anhydride 、 N,N-二甲基乙二胺 以 氯仿 为溶剂， 反应 24.0h， 以90%的产率得到2-[(2-dimethylamino)ethyl]-6-phenyl-1H-benz[de]isoquinoline-1,3(2H)-dione
  参考文献：
  名称：

  Synthesis, Biological Activity, and Quantitative Structure−Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives

  摘要：

  A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.

  DOI：

  10.1021/jm0310784
• 作为产物：
  描述：

  4-溴-1,8-萘二甲酸酐 、 三丁基苯基锡 在 四(三苯基膦)钯 作用下， 以 1,4-二氧六环 为溶剂， 反应 48.0h， 以89%的产率得到4-phenylnaphthalic anhydride
  参考文献：
  名称：

  Synthesis, Biological Activity, and Quantitative Structure−Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives

  摘要：

  A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.

  DOI：

  10.1021/jm0310784

文献信息

• Process for producing biaryl compound
  申请人：Hagiya Koji

  公开号：US20050096471A1

  公开（公告）日：2005-05-05

  A process for producing a biaryl compound, characterized by reacting an arylhydrazine compound, hydrogen peroxide and an aryl compound. When the reaction is conducted in the presence of a given metal or a compound of the metal or in the presence of a metal oxide obtained by reacting the given metal or a compound of the metal with hydrogen peroxide, then the yield of the biaryl compound is improved.

  一种生产双芳基化合物的工艺，其特征在于使芳基肼化合物、过氧化氢和芳基化合物反应。当反应是在某种金属或金属化合物存在下进行，或在某种金属或金属化合物与过氧化氢反应得到的金属氧化物存在下进行时，双芳基化合物的产率会提高。
• PROCESS FOR PRODUCING BIARYL COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1473286B1

  公开（公告）日：2009-11-04
• US7554000B2
  申请人：——

  公开号：US7554000B2

  公开（公告）日：2009-06-30
• US8242278B2
  申请人：——

  公开号：US8242278B2

  公开（公告）日：2012-08-14
• Synthesis, Biological Activity, and Quantitative Structure−Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives
  作者：Miguel F. Braña、Ana Gradillas、Angel Gómez、Nuria Acero、Francisco Llinares、Dolores Muñoz-Mingarro、Cristina Abradelo、Fernanda Rey-Stolle、Mercedes Yuste、Joaquín Campos、Miguel Á. Gallo、Antonio Espinosa

  DOI：10.1021/jm0310784

  日期：2004.4.1

  A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.