N,N'-dimethyl-2,2-bis-methylaminomethyl-propanediyldiamine | 154074-32-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-dimethyl-2,2-bis-methylaminomethyl-propanediyldiamine
• 英文别名: N,N'-Dimethyl-2,2-bis-methylaminomethyl-propandiyldiamin；Tetrakis-methylaminomethyl-methan；tetrakis(methylaminomethyl)methane；N,N'-dimethyl-2,2-bis(methylaminomethyl)propane-1,3-diamine
• CAS: 154074-32-5
• 化学式: C₉H₂₄N₄
• 分子量: 188.316
• InChiKey: RGQHZRDDTDTAHL-UHFFFAOYSA-N

物化性质

• 沸点：
  387.3±10.0 °C(Predicted)
• 密度：
  0.886±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  48.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-溴-2,4-二硝基苯 、 N,N'-dimethyl-2,2-bis-methylaminomethyl-propanediyldiamine 在 乙醇 、 sodium acetate 作用下， 生成 N,N'-bis-(2,4-dinitro-phenyl)-N,N'-dimethyl-2,2-bis-[(N-methyl-2,4-dinitro-anilino)-methyl]-propanediyldiamine
  参考文献：
  名称：

  van Alphen, Recueil des Travaux Chimiques des Pays-Bas, 1938, vol. 57, p. 265,276

  摘要：

  DOI：
• 作为产物：
  描述：

  季戊四醇 在 乙醇 、 三溴化磷 作用下， 生成 N,N'-dimethyl-2,2-bis-methylaminomethyl-propanediyldiamine
  参考文献：
  名称：

  van Alphen, Recueil des Travaux Chimiques des Pays-Bas, 1938, vol. 57, p. 265,276

  摘要：

  DOI：

文献信息

• PROTECTED FLUORESCENT REAGENT COMPOUNDS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20150050659A1

  公开（公告）日：2015-02-19

  Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.

  提供了受保护的荧光试剂化合物及其合成方法。这些化合物在各种基于荧光的分析方法中很有用，包括在高密度下对大量高度多重光学反应进行分析，例如单分子实时核酸测序反应。这些化合物包含荧光染料元素，使得这些化合物能够在理想波长下以高灵敏度被检测到，结合元素，使得这些化合物能够被特异性地识别目标生物分子，并且保护盾元素，减少荧光染料元素与结合的目标生物分子之间的不良接触，从而减少荧光染料元素对结合的目标生物分子造成的光损伤。
• MULTIMERIC PROTECTED FLUORESCENT REAGENTS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20160237279A1

  公开（公告）日：2016-08-18

  Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.

  提供了多聚保护荧光试剂及其合成方法。这些试剂在各种基于荧光的分析方法中很有用，包括在高密度下分析高度多重光学反应，比如单分子实时核酸测序反应。这些试剂包含荧光染料元素，允许化合物在理想波长下以高灵敏度被检测，结合元素，允许化合物被目标生物分子特异性识别，以及保护屏障元素，减少荧光染料元素与结合的目标生物分子之间的不良接触，从而减少荧光染料元素对结合的目标生物分子的光损伤。这些试剂还包含耦合元素，将单体化合物连接成多聚形式，从而增加亮度。
• MODIFIED NUCLEOTIDE REAGENTS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20170321268A1

  公开（公告）日：2017-11-09

  Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.

  提供了包含至少一种亲和素蛋白、至少一种染料标记化合物和至少一种核苷酸化合物的标记核苷酸类似物。这些类似物在各种基于荧光的分析方法中很有用，包括在高密度下对大量高度多重光学反应进行分析，例如单分子实时核酸测序反应。这些类似物在理想波长下具有高灵敏度的可检测性。它们包含调节类似物与DNA聚合酶相互作用的结构组分，从而减少光损伤，并改善测序反应中类似物的动力学和其他性质。还提供了主题类似物的核苷酸和染料标记化合物，以及在制备这些化合物和类似物中有用的中间体。还提供了包含这些化合物的组合物、合成这些中间体、化合物和类似物的方法，以及突变的DNA聚合酶。
• ALPHA-HYDROXYKETONES
  申请人：Dietliker Kurt

  公开号：US20100104979A1

  公开（公告）日：2010-04-29

  Compounds of the Formula (I) wherein x is an integer from 1-4; p is an integer from 1-3; q is an integer from 0-3; Ar is phenyl, naphthyl, anthryl or phenanthryl each of which optionally is substituted by one or more Cl, CN, OR 5 , C 3 -C 5 alkenyl or C 1 -C 6 alkyl which optionally is substituted by one or more OR 6 , COOR or halogen; R 1 if x is 1, is OR S , O—X + , NR 8 R 9 , C 1 -C 20 alkyl optionally substituted by one or more COOR 10 , or is C 2 -C 20 alkyl interrupted by one ore more O, or is C 2 -C 5 alkenyl or phenyl-C 1 -C 4 alkyl; R 1 if x is 2, is for example C 1 -C 20 alkylene; R 1 if x is 3, is for example a tri-valent radical; R 1 if x is 4, is for example a tetravalent radical; R 2 and R 3 are hydrogen or C 1 -C 8 alkyl, or R 2 and R 3 together are O, C 1 -C 3 alkylene or CH═CH; R 4 is C 1 -C 4 alkyl; R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are for example hydrogen or C 1 -C 4 alkyl; and X is a x-valent cationic counter ion; are in particular suitable as photoinitiators for the curing with UV-A light (320-450 nm).

  化合物的公式（I），其中x是1-4之间的整数；p是1-3之间的整数；q是0-3之间的整数；Ar是苯基，萘基，蒽基或苊基，每个都可以选择性地被一个或多个Cl，CN，OR5，C3-C5烯基或C1-C6烷基取代，这些烷基可以选择性地被一个或多个OR6，COOR或卤素取代；如果x为1，则R1为ORS，O-X+，NR8R9，C1-C20烷基，可以选择性地被一个或多个COOR10取代，或者是被一个或多个O中断的C2-C20烷基，或者是C2-C5烯基或苯基-C1-C4烷基；如果x为2，则R1例如为C1-C20烷基；如果x为3，则R1例如为三价基团；如果x为4，则R1例如为四价基团；R2和R3为氢或C1-C8烷基，或者R2和R3一起为O，C1-C3亚烷基或CH═CH；R4为C1-C4烷基；R5，R6，R7，R8，R9和R10例如为氢或C1-C4烷基；X为x价阳离子对离子。这些化合物特别适用于使用UV-A光（320-450 nm）进行固化的光引发剂。
• DITHIOCARBONATE COMPOSITION
  申请人：Kyowa Yuka Co., Ltd.

  公开号：EP0943660A1

  公开（公告）日：1999-09-22

  The present invention provides a composition comprising a polymer or a compound having at least one 5-membered ring dithiocarbonate group represented by general formula (I): (wherein, in the formula, R1, R2, and R3 are the same or different, each of which denotes hydrogen or a lower alkyl), and a ketimine derivative, an enamine derivative, or an aldimine derivative. The composition is useful in coatings, adhesives, inks, sealing agents, sealants, and the like.

  本发明提供了一种组合物，该组合物包含通式(I)所代表的至少具有一个五元环二硫代碳酸酯基团的聚合物或化合物： (其中，式中 R1、R2 和 R3 相同或不同，各表示氢或低级烷基），以及酮亚胺衍生物、烯胺衍生物或醛亚胺衍生物。该组合物可用于涂料、粘合剂、油墨、密封剂、密封胶等。