3-(Adamantan-1-ylamino)-1-phenyl-propan-1-ol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(Adamantan-1-ylamino)-1-phenyl-propan-1-ol
• 英文别名: 3-(1-Adamantylamino)-1-phenylpropanol；3-(1-adamantylamino)-1-phenylpropan-1-ol
• 化学式: C₁₉H₂₇NO
• 分子量: 285.429
• InChiKey: XXBRJGCJCMOIFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR MANUFACTURING ADAMANTANE DERIVATIVES WITH HIGH YIELD<br/>[FR] PROCÉDÉ POUR LA FABRICATION DE DÉRIVÉS D'ADAMANTANE AVEC UN RENDEMENT ÉLEVÉ
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2010015415A1

  公开（公告）日：2010-02-11

  The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine: substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.

  本发明涉及一种取代的1-溴金刚烷的酰胺化过程，包括步骤（0）反应取代金刚烷和过量溴化合成1-溴金刚烷，以及步骤（i）反应所述取代的1-溴金刚烷与酰胺反应，其中所述取代的1-溴金刚烷以步骤（0）得到的含有溴的混合物的形式使用，其中在步骤（0）中使用溴：取代金刚烷的摩尔比为[2.5:1]至少于[5:1]。
• PROCESS FOR MANUFACTURING ADAMANTANE DERIVATIVES WITH HIGH YIELD
  申请人：Merz Pharma GmbH & Co. KGaA

  公开号：EP2331495A1

  公开（公告）日：2011-06-15
• PROCESS FOR MANUFACTURING ADAMANTANE DERVATIVES WITH HIGH YIELD
  申请人：Gold Markus-Rene

  公开号：US20110263900A1

  公开（公告）日：2011-10-27

  The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine:substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.
• US8796491B2
  申请人：——

  公开号：US8796491B2

  公开（公告）日：2014-08-05