2,12-Bis[(dimethylamino)methyl]cyclododecanone

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,12-Bis[(dimethylamino)methyl]cyclododecanone
• 英文别名: 2,12-bis[(dimethylamino)methyl]cyclododecan-1-one
• 化学式: C₁₈H₃₆N₂O
• 分子量: 296.5
• InChiKey: HRQRILLGGNNYSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• METHODS FOR SELECTIVELY INHIBITING JANUS TYROSINE KINASE 3 (JAK3)
  申请人：KIRKEN Robert A.

  公开号：US20080167220A1

  公开（公告）日：2008-07-10

  Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a derivative or modified compound, is employed which is capable of selectively inhibiting Jak 3 while affecting other protein tyrosine kinase activities to a lesser extent or not at all, to provide beneficial effects such as mitigation of transplant rejection and alleviation of allergic responses with fewer side effects than with conventional immunosuppressive agents.
• US7365096B2
  申请人：——

  公开号：US7365096B2

  公开（公告）日：2008-04-29
• US7928062B2
  申请人：——

  公开号：US7928062B2

  公开（公告）日：2011-04-19